Contrast Material–enhanced Abdominal US Examinations with DMP 115 (DEFINITY) Provides Additional Diagnostic Information with Potential for Changes in Patient Management

2002 ◽  
Vol 9 (1) ◽  
pp. S243-S245 ◽  
Author(s):  
M.L. Rosenberg ◽  
A.P. Carpenter ◽  
the Phase III DEFINITY Clinical Investigators
Keyword(s):  
Patient Management ◽  
Contrast Material ◽  
Diagnostic Information ◽  
Additional Diagnostic Information

Can multiphase dynamic CT angiography provide a better assessment of aortic dissection compared with the standard triphasic protocol?

2017 ◽  
Vol 59 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Chun-yan Lu ◽  
Yi-ke Diao ◽  
Ying-qiang Guo ◽  
Xiao-hui Zhang ◽  
Hong-li Bai ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Contrast Material ◽  
False Lumen ◽  
Diagnostic Information ◽  
Medical Emergency ◽  
Left Renal Artery ◽  
High Pitch ◽  
Effective Radiation Dose ◽  
Additional Diagnostic Information ◽  
Pitch Mode

Background Acute aortic dissection (AD) is a life-threatening medical emergency. It has been debated whether the multiphase dynamic computed tomography angiography (CTA) protocol is superior to the standard triphasic protocol for revealing the characteristics of AD. Purpose To examine two multiphase dynamic protocols, Dynamic four-dimensional (4D) CTA using the shuttle mode and Flash 4D CTA using the high-pitch mode for the assessment of AD and to compare them with the standard triphasic protocol. Material and Methods A total of 54 consecutive patients were randomly and equally assigned to three groups and scanned with a second-generation DSCT scanner. Groups A, B, and C were assessed with the Dynamic 4D CTA in the shuttle mode, the Flash 4D CTA in the high-pitch mode, and the standard triphasic acquisition protocol, respectively. Image quality of all patients was evaluated. The effective radiation dose (ED) was recorded. Results In 54 patients, CTA images could display the true and false lumens, the intimal flap, the entry tear, and branch vessel involvement in the AD. Compared with group C, additional diagnostic information was obtained in groups A and B, including the dynamic enhancement delay between the true and false lumens (A = 18, B = 18); the presence of membrane oscillation (A = 8, B = 14); dynamic ejection of the contrast material from the true lumen into the false lumen (A = 6, B = 7); and the dynamic obstruction of the left renal artery (B = 2). The ED in these three groups was significantly different ( P < 0.05). Conclusion Compared to the standard triphasic protocol, the multiphase dynamic CTA protocol is feasible and is able to reveal additional diagnostic information. Therefore, we recommend using the high-pitch, dual-source multiphase dynamic CTA to assess ADs.

The therapeutic impact of 18F-FDG whole body PET

2005 ◽  
Vol 44 (01) ◽  
pp. 8-14 ◽  
Author(s):  
B. Dietl ◽  
J. Marienhagen
Keyword(s):  
Fdg Pet ◽  
Diagnostic Information ◽  
Whole Body ◽  
Therapeutic Concept ◽  
Therapeutic Impact ◽  
Additional Diagnostic Information ◽  
Therapeutic Decisions ◽  
Target Volumes ◽  
18F Fdg ◽  
Pet Scans

Summary Aims: An explorative analysis of the diagnostic as well as therapeutic impact of 18F-FDG whole body PET on patients with various tumours in the setting of an university hospital radiation therapy was performed. Patients and methods: 222 FDG PET investigations (148 initial stagings, 74 restagings) in 176 patients with diverse tumour entities (37 lung carcinoma, 15 gastrointestinal tumours, 38 head and neck cancer, 30 lymphoma, 37 breast cancer, 19 sarcoma and 16 other carcinomas) were done. All PET scans were evaluated in an interdisciplinary approach and consecutively confirmed by other imaging modalities or biopsy. Unconfirmed PET findings were ignored. Proportions of verified PET findings, additional diagnostic information (diagnostic impact) and changes of the therapeutic concept intended and documented before PET with special emphasis on radiooncological decisions (therapeutic impact) were analysed. Results: 195/222 (88%) FDG-PET findings were verified, 104/222 (47%) FDG-PET scans yielded additional diagnostic information (38 distant, 30 additional metastasis, 11 local recurrencies, 10 primary tumours and 15 residual tumours after chemoptherapy). The results of 75/222 (34%) scans induced changes in cancer therapy and those of 58/222 (26%) scans induced modifications of radiotherapeutic treatment plan (esp. target volumes). Conclusion: 18F-FDG whole body PET is a valuable diagnostic tool for therapy planning in radiooncology with a high impact on therapeutic decisions in initial staging as well as in restaging. Especially in a curative setting it should be used for definition of target volumes.

MR Imaging of Pituitary Region Lesions with Gadodiamide Injection

1994 ◽  
Vol 35 (1) ◽  
pp. 65-69
Author(s):  
J. K. Hald ◽  
I. O. Skalpe ◽  
S. J. Bakke ◽  
P. H. Nakstad
Keyword(s):  
Mr Imaging ◽  
Contrast Medium ◽  
Image Enhancement ◽  
Gadopentetate Dimeglumine ◽  
Diagnostic Information ◽  
High Dose ◽  
Mr Image ◽  
Additional Diagnostic Information ◽  
Pathologic Lesions

Twelve patients with known or suspected pituitary lesions underwent MR imaging with gadodiamide injection at a dose of 0.1 (n = 5) or 0.3 (n = 7) mM/kg. Six of the patients were also studied with 0.1 mM/kg gadopentetate dimeglumine. Consistent with previous reports gadodiamide injection was found to be a safe and effective contrast medium for MR imaging of the pituitary region. No additional diagnostic information was obtained using 0.3 mM/kg gadodiamide injection compared to 0.1 mM/kg gadopentetate dimeglumine in the same patients. The high dose (0.3 mM/kg) gadodiamide injection in 7 patients did not shorten the T2 value sufficiently to overwhelm the T1 shortening and leave pathologic lesions hypointense compared to precontrast studies. With the comparable relaxivities of gadodiamide injection and gadopentetate dimeglumine, similarities in results have to be expected when using these media for MR image enhancement.

An Algorithmic Approach to the Diagnosis of Pancreatic Neoplasms

2009 ◽  
Vol 133 (3) ◽  
pp. 454-464 ◽  
Author(s):  
David S. Klimstra ◽  
Martha B. Pitman ◽  
Ralph H. Hruban
Keyword(s):  
Differential Diagnosis ◽  
Pancreatic Neoplasms ◽  
Pancreatic Neoplasm ◽  
Diagnostic Information ◽  
Data Sources ◽  
Algorithmic Approach ◽  
Normal Gland ◽  
Pathologic Evaluation ◽  
Additional Diagnostic Information

Abstract Context.—The pancreas gives rise to an array of distinct neoplasms that can be solid, cystic, or intraductal and can recapitulate the various lines of differentiation present in the normal gland. Objective.—To develop an algorithmic approach to the diagnosis of pancreatic neoplasms that simplifies their pathologic evaluation. Data Sources.—We reviewed literature related to the classification of pancreatic neoplasms on the basis of their gross, histologic, and immunohistochemical features. Conclusions.—By using a series of dichotomous decisions, the differential diagnosis of a pancreatic neoplasm can be narrowed, and in cases of the more common neoplasms, accurate classification can be achieved. Uncommon neoplasms not accounted for by this approach are also discussed, and the additional diagnostic information needed for complete pathologic reporting is presented.

Analysis of Addenda in Anatomic Pathology as a Quality Monitoring Initiative

2014 ◽  
Vol 138 (11) ◽  
pp. 1514-1519 ◽  
Author(s):  
Jesse Paul Babwah ◽  
Mahmoud Khalifa ◽  
Corwyn Rowsell
Keyword(s):  
Patient Management ◽  
Treatment Plan ◽  
Diagnostic Information ◽  
Molecular Techniques ◽  
Surgical Pathology ◽  
Quality Monitoring ◽  
Routine Practice ◽  
Original Diagnosis ◽  
Additional Information ◽  
Immunohistochemical Markers

Context Along with the integration of immunohistochemical markers and molecular techniques into routine practice, addenda in surgical pathology reporting have not only increased in frequency but also evolved to include prognostic and therapeutic information. Because of the lack of uniform practice with respect to issuing addenda, information that can significantly change the diagnosis, prognosis, or treatment plan may be issued as an addendum as opposed to an amendment. Objective To audit addenda and identify instances of amendments masquerading as addenda. Design All addenda during a 36-month period were reviewed. Each addendum report was classified by accession class, issuing pathologist, subspecialty category, indication for addendum, whether the addendum constituted a change in diagnostic meaning, whether a change in prognosis occurred, and if a change in treatment plan was necessary. Results All cytology and autopsy addenda were deemed appropriate. Thirty-three of 5028 (6.5 of 1000) surgical pathology addenda were deemed to have changes: Among the 33 faux addenda, 30 (91%) contained supplemental diagnostic information that would alter patient management and 31 (94%) contained additional information that would change the prognosis from that entailed by the original diagnosis. Conclusions Our study demonstrates that not infrequently, surgical pathology addenda contain information that significantly alters the report and thus merit an amendment. Quality monitoring initiatives that evaluate pathologist and departmental performance should assess both addenda and amendments.

Tokens of love: possible diagnostic value of mating plugs and refractive secretory uterine structures in Trichodorus (Diphtherophorina: Trichodoridae)

Nematology ◽  
2012 ◽  
Vol 14 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Wilfrida Decraemer
Keyword(s):  
Diagnostic Value ◽  
Central Canal ◽  
Diagnostic Information ◽  
Species Level ◽  
Tubular Structures ◽  
Secretory Structures ◽  
Additional Diagnostic Information

Within the Trichodoridae, mating plugs have only been recorded from Trichodorus species. They can be observed as a clear plug within the vagina/vulva but may also be present in the uteri. These secretory structures are diverse in size, varying between 4 and 27 μm in length, and in shape from simple unipartite tubular structures to bipartite with a central indentation or with a tail-like end. All mating plugs possess a central canal that can vary in diameter. Within Trichodorus, the shape and structure of the mating plugs can provide additional diagnostic information at species level.

Failure of the Treponema pallidum lmmobilization Test to Provide Additional Diagnostic Information about Contemporary Problem Sera

1980 ◽  
Vol 7 (3) ◽  
pp. 101-105 ◽  
Author(s):  
MICHAEL F. REIN ◽  
GILBERT W. BANKS ◽  
LESLIE C. LOGAN ◽  
SANDRA A. LARSEN ◽  
JOHN C. FEELEY ◽  
...  
Keyword(s):  
Contemporary Problem ◽  
Treponema Pallidum ◽  
Diagnostic Information ◽  
Additional Diagnostic Information
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