An Overview of Pancreatic Neuroendocrine Tumors

Pancreatic neuroendocrine tumors are a group of endocrine tumors that constitute 7% of all pancreatic neoplasms. They can be benign or malignant. Their presentation can vary from slow growing, non infiltrative, indolent masses to rapidly progressing, highly aggressive, metastasizing tumors. In the past, there was paucity of scientific data available about the diagnosis and treatment strategy of these neoplasms but in recent years, ongoing research has inferred much data regarding classification, prognostic stratification and therapy of pancreatic neuroendocrine tumors. In this chapter we will discuss epidemiology, clinical presentation and classification, diagnosis and management of these tumors. We will also deliberate about the latest developments in treatment of pancreatic neuroendocrine tumors with focus on recent studies done on this topic.

Recent Advances in Pancreatic Neoplasms

Pancreatic neoplasms, both primary and secondary, include different pathological entities with variable biological behavior and, consequently, different treatment modalities [...]

Mucinous Cystadenocarcinoma of Pancreas - USG and CT Evaluation - A Case Report

Cystic neoplasms of the pancreas comprise a pathologically heterogeneous group of tumours with many shared clinical features. Although relatively uncommon, they have a very important place within the surgical pathology of the pancreas because of their high cure rate and their potential (and not infrequent) confusion with the far more common pancreatic pseudocysts. Their exact incidence is unknown, but it is frequently quoted that they constitute about 10 % of all cystic lesions of the pancreas.1 The cystic pancreatic lesions are pathologically classified as - cystic teratoma, common cystic pancreatic neoplasms (serous cystadenoma, mucinous cystic neoplasm, intraductal papillary mucinous neoplasm (IPMN), pseudocyst, rare cystic pancreatic neoplasms (solid pseudopapillary tumour, acinar cell cystadenocarcinoma, lymphangioma, haemangioma, paraganglioma), sarcoma, true epithelial cysts (associated with Von Hippel–Lindau disease, autosomal - dominant polycystic kidney disease, and cystic fibrosis), metastasis, solid pancreatic lesions with cystic degeneration (pancreatic adenocarcinoma, cystic islet cell tumour (insulinoma, glucagonoma, gastrinoma).2 Mucinous cystadenoma of pancreas are more commonly seen in middle‑aged females as compared with males.[5,6] Cystadenomas of the pancreas are low‑grade tumours and they constitute about 10 % of pancreatic cysts.3 Their most common location is the body and tail, with the head being a less common site.4 These tumours are more commonly seen in the middle of the pancreas.

Non Hodgkin Lymphoma Presenting as a Pancreatic Mass-Treated Successfully with R-Chop

Primary pancreatic lymphomas are extremely rare, when present mimics symptoms of adenocarcinoma of the pancreatic head. They account for less than 1% of pancreatic neoplasms [2]. The most common histological subtype is diffuse large B cell lymphoma (DLBCL) [3]. Herein, we present a case of a 47 year old female who presented with symptoms of pain abdomen and weight loss. CT (Computerized Tomography) was suggestive of a lesion in the pancreatic head which on histopathology was diagnosed as a primary non-Hodgkin’s lymphoma confirmed by immunohistochemistry.

SOLID PSEUDOPAPILLARY NEOPLASM OF THE PANCREAS: PRESENTATION OF A CASE AND REVIEW OF THE LITERATURE

Solid pseudopapillary neoplasms (SPN) of the pancreas are rare tumors, occurring in 1-2% of all pancreatic neoplasms; of these 10 to 15% have an aggressive presentation. Most of the patients present disease localized to the pancreas, however, between 9-15% may present local invasion and metastasis. The clinical presentation in the vast majority of SPN is asymptomatic, even despite a large tumor size. We present a case of a 16-year-old female patient with a psedupapillary tumor of the pancreas (Frantz tumor) who was admitted due to abdominal pain and weight loss lasting 3 months.