Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials

2006 ◽  
Vol 97 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Martin Penagos ◽  
Enrico Compalati ◽  
Francesco Tarantini ◽  
Rodrigo Baena-Cagnani ◽  
Jose Huerta ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pediatric Patients ◽  
Sublingual Immunotherapy ◽  
Meta Analysis ◽  
Double Blind ◽  
Blind Trials

QUESTION FOR META-ANALYSTS: CAN YOU MAKE A SILKEN PURSE OUT OF A SOW'S EAR?

PEDIATRICS ◽  
1989 ◽  
Vol 84 (4) ◽  
pp. A108-A108
Author(s):  
Student
Keyword(s):  
Rheumatoid Arthritis ◽  
Meta Analysis ◽  
Multiple Comparisons ◽  
Measurement Scales ◽  
Double Blind ◽  
New Drug ◽  
Baseline Difference ◽  
Blind Trials

Choice of dose [in 196 double-blind trials of treatments for rheumatoid arthritis], multiple comparisons, wrong calculation, sub-group and within-group analyses, wrong sampling units. . . , change in measurement scales before analyses, baseline difference, and selecting reporting of significant results were some of the verified or possible causes for the large proportion of results that favored the [newly proposed] drug. Doubtful or invalid statements were found in 76% of the conclusions or abstracts. Bias consistently favored the new drug in 81 trials, and the control in only one trial. It is not obvious how a reliable meta-analysis could be done [reliably] in these trials.

Efficacy of sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A systematic review and meta-analysis

2010 ◽  
Vol 126 (3) ◽  
pp. 558-566 ◽  
Author(s):  
Danilo Di Bona ◽  
Antonella Plaia ◽  
Valeria Scafidi ◽  
Maria Stefania Leto-Barone ◽  
Gabriele Di Lorenzo
Keyword(s):  
Systematic Review ◽  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Sublingual Immunotherapy ◽  
Meta Analysis
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