Clinical Efficacy of Phytodolor under special consideration of double-blind trials and their meta-analysis

Choice of dose [in 196 double-blind trials of treatments for rheumatoid arthritis], multiple comparisons, wrong calculation, sub-group and within-group analyses, wrong sampling units. . . , change in measurement scales before analyses, baseline difference, and selecting reporting of significant results were some of the verified or possible causes for the large proportion of results that favored the [newly proposed] drug. Doubtful or invalid statements were found in 76% of the conclusions or abstracts. Bias consistently favored the new drug in 81 trials, and the control in only one trial. It is not obvious how a reliable meta-analysis could be done [reliably] in these trials.

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Randomized, placebo controlled and double-blind trials of efficacy and safety of adalimumab for treating ankylosing spondylitis: a meta-analysis

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.12245 ◽

2014 ◽

Vol 17 (2) ◽

pp. 142-148 ◽

Cited By ~ 12

Author(s):

Hongsheng Wang ◽

Dongqing Zuo ◽

Mengxiong Sun ◽

Yingqi Hua ◽

Zhengdong Cai

Keyword(s):

Ankylosing Spondylitis ◽

Meta Analysis ◽

Efficacy And Safety ◽

Double Blind ◽

Blind Trials

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Statins in hypercholesterolaemia: A dose-specific meta-analysis of lipid changes in randomised, double blind trials

BMC Family Practice ◽

10.1186/1471-2296-4-18 ◽

2003 ◽

Vol 4 (1) ◽

Cited By ~ 96

Author(s):

Jayne E Edwards ◽

R Andrew Moore

Keyword(s):

Meta Analysis ◽

Double Blind ◽

Blind Trials

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Efficacy of the combination of nilutamide plus orchidectomy in patients with metastatic prostatic cancer. A meta-analysis of seven randomized double-blind trials (1056 patients)

British Journal of Urology ◽

10.1111/j.1464-410x.1994.tb07603.x ◽

1994 ◽

Vol 73 (4) ◽

pp. 396-402 ◽

Cited By ~ 64

Author(s):

C. BERTAGNA ◽

A. DE GÉRY ◽

M. HUCHER ◽

J. P. FRANÇOIS ◽

J. ZANIRATO

Keyword(s):

Prostatic Cancer ◽

Meta Analysis ◽

Double Blind ◽

Blind Trials ◽

Metastatic Prostatic Cancer

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MP415EFFECT OF INTRAVENOUS IRON THERAPY WITH FERRIC CARBOXYMALTOSE ON OUTCOMES IN IRON-DEFICIENT PATIENTS WITH RENAL DYSFUNCTION AND HEART FAILURE WITH REDUCED EJECTION FRACTION: AN INDIVIDUAL PATIENT DATA META-ANALYSIS OF FOUR RANDOMIZED, DOUBLE-BLIND TRIALS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx171.mp415 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii581-iii581 ◽

Cited By ~ 1

Author(s):

Piotr Ponikowski ◽

Iain Macdougall ◽

Michael Böhm ◽

Josep Comin Colet ◽

Gerasimos Filippatos ◽

...

Keyword(s):

Heart Failure ◽

Individual Patient Data ◽

Meta Analysis ◽

Intravenous Iron ◽

Ferric Carboxymaltose ◽

Double Blind ◽

Reduced Ejection Fraction ◽

Iron Deficient ◽

Intravenous Iron Therapy ◽

Blind Trials

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Exaggeration of the bleeding risk and thrombotic risk with antiangiogenic therapies in open-label trials compared to double-blind trials in cancer patients: A systematic review and meta-analysis

Revue d Épidémiologie et de Santé Publique ◽

10.1016/j.respe.2017.03.025 ◽

2017 ◽

Vol 65 ◽

pp. S57-S58

Author(s):

J.C. Trone ◽

C. Chapelle ◽

E. Ollier ◽

L. Bertoletti ◽

M. Cucherat ◽

...

Keyword(s):

Systematic Review ◽

Cancer Patients ◽

Meta Analysis ◽

Bleeding Risk ◽

Open Label ◽

Double Blind ◽

Thrombotic Risk ◽

Antiangiogenic Therapies ◽

Blind Trials

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MP417IMPACT OF INTRAVENOUS FERRIC CARBOXYMALTOSE IRON THERAPY ON SYMPTOMS AND FUNCTIONALITY IN IRON-DEFICIENT PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION AND RENAL DYSFUNCTION: AN INDIVIDUALPATIENT DATA META-ANALYSIS OF 4 RANDOMIZED, DOUBLE-BLIND TRIALS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx171.mp417 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii581-iii582

Author(s):

Piotr Ponikowski ◽

Iain Macdougall ◽

Michael Böhm ◽

Josep Comin Colet ◽

Gerasimos Filippatos ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Renal Dysfunction ◽

Meta Analysis ◽

Ferric Carboxymaltose ◽

Double Blind ◽

Reduced Ejection Fraction ◽

Iron Deficient ◽

Patients With Heart Failure ◽

Blind Trials

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Zuclopenthixol, melperone and haloperidol/levomepromazine in the elderly. Meta-analysis of two double-blind trials at 15 nursing homes in Norway

Current Medical Research and Opinion ◽

10.1185/03007999209111528 ◽

1992 ◽

Vol 12 (10) ◽

pp. 615-622 ◽

Cited By ~ 7

Author(s):

H. A. Nygaard ◽

E. Fuglum ◽

K. Elgen

Keyword(s):

Nursing Homes ◽

Meta Analysis ◽

The Elderly ◽

Double Blind ◽

Blind Trials

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Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials

Annals of Allergy Asthma & Immunology ◽

10.1016/s1081-1206(10)60004-x ◽

2006 ◽

Vol 97 (2) ◽

pp. 141-148 ◽

Cited By ~ 232

Author(s):

Martin Penagos ◽

Enrico Compalati ◽

Francesco Tarantini ◽

Rodrigo Baena-Cagnani ◽

Jose Huerta ◽

...

Keyword(s):

Allergic Rhinitis ◽

Pediatric Patients ◽

Sublingual Immunotherapy ◽

Meta Analysis ◽

Double Blind ◽

Blind Trials

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Clinical Effect of Encephabol (Pyritinol) in the Treatment of Cerebrovascular Disorders

Journal of International Medical Research ◽

10.1177/030006058000800203 ◽

1980 ◽

Vol 8 (2) ◽

pp. 118-126 ◽

Cited By ~ 9

Author(s):

Yoshiaki Tazaki ◽

Teruo Omae ◽

Shoshiro Kuromaru ◽

Eiichi Ohtomo ◽

Kazuo Hasegawa ◽

...

Keyword(s):

Clinical Efficacy ◽

Clinical Effect ◽

Cerebrovascular Disorders ◽

Double Blind ◽

Blind Trials

The results of a series of multicentre, controlled, double-blind trials of the clinical efficacy of Encephabol compared with placebo in patients with a variety of cerebrovascular disorders are reported.

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