316 INFLAMMATORY PAIN ALTERS AFFERENT INPUT TO NK1 RECEPTOR EXPRESSING LAMINA I RAT SPINAL CORD NEURONS

2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
C. Torsney
Keyword(s):  
Spinal Cord ◽  
Inflammatory Pain ◽  
Afferent Input ◽  
Nk1 Receptor ◽  
Rat Spinal Cord ◽  
Spinal Cord Neurons ◽  
Lamina I

scholarly journals Urotensin-II regulates intracellular calcium in dissociated rat spinal cord neurons

2002 ◽  
Vol 83 (4) ◽  
pp. 879-884 ◽  
Author(s):  
Catalin M. Filipeanu ◽  
Eugen Brailoiu ◽  
Siok Le Dun ◽  
Nae J. Dun
Keyword(s):  
Spinal Cord ◽  
Intracellular Calcium ◽  
Urotensin Ii ◽  
Rat Spinal Cord ◽  
Spinal Cord Neurons

Responses of T2-4 spinal cord neurons to irritation of the lower airways in the rat

1997 ◽  
Vol 273 (3) ◽  
pp. R1147-R1157 ◽  
Author(s):  
T. Hummel ◽  
J. N. Sengupta ◽  
S. T. Meller ◽  
G. F. Gebhart
Keyword(s):  
Spinal Cord ◽  
Afferent Input ◽  
Sprague Dawley ◽  
Spinal Neurons ◽  
Thoracic Spinal Cord ◽  
Spinal Cord Neurons ◽  
Thoracic Spinal ◽  
Balloon Distension ◽  
Sprague Dawley Rats ◽  
Lower Airways

The aim of the study was to investigate the information processing in the thoracic spinal cord (T2-4) after chemical irritation of the lower airways. Experiments were performed in pentobarbital sodium-anesthetized and pancuronium-paralyzed male Sprague-Dawley rats. Balloon distension of the esophagus was used as the search stimulus. Ammonia and smoke were applied by means of a tracheal cannula; they produced excitatory, inhibitory, and biphasic responses in a concentration-related manner (ammonia 39/39; smoke 23/ 39). Inhaled irritant-responsive neurons exhibited a number of similarities that have been described for neurons responding to stimulation of other thoracic viscera. These similarities relate to the distribution of neurons in the deeper laminae of the thoracic spinal cord, the relatively small number of neurons receiving input from the lower airways, the extensive convergent input from the skin and other thoracic viscera, and the pattern of responses. In addition, both stimulus-induced responses and spontaneous activity are subject to modulation from supraspinal sites. On the basis of responses to inhaled irritants after either spinal cord or vagus nerve block/transection, these T2-4 spinal neurons are likely to receive spinal afferent input that is modulated by vagal-brain stem input.

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