No Travel History? Don't Rule Out Hepatitis E

2012 ◽  
Vol 45 (1) ◽  
pp. 69
Author(s):  
SUSAN LONDON
Keyword(s):  
Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1265
Author(s):  
Boris M. Hogema ◽  
Renate W. Hakze-van der Hakze-van der Honing ◽  
Michel Molier ◽  
Hans L. Zaaijer ◽  
Wim H. M. van der van der Poel

Pigs are suspected to be a major source of zoonotic hepatitis E virus (HEV) infection in industrialized countries, but the transmission route(s) from pigs to humans are ill-defined. Sequence comparison of HEV isolates from pigs with those from blood donors and patients in 372 samples collected in the Netherlands in 1998 and 1999 and between 2008 and 2015 showed that all sequences were genotype 3 except for six patients (with travel history). Subgenotype 3c (gt3c) was the most common subtype. While the proportion of gt3c increased significantly between 1998 and 2008, it remained constant between 2008 and 2015. Among the few circulating HEV subtypes, there was no difference observed between the human and the pig isolates. Hepatitis E viruses in humans are very likely to originate from pigs, but it is unclear why HEV gt3c has become the predominant subtype in the Netherlands.


2020 ◽  
Vol 13 (12) ◽  
pp. e236922
Author(s):  
Rosa Maja Møhring Gynthersen ◽  
Christian Philip Rønn ◽  
Christian Thomas Brandt ◽  
Helene Mens

We present a case of a 50-year-old man admitted due to acute abdomen, icterus and fever. The patient had a history of sufficiently treated type 2 diabetes and a high daily alcohol consumption, no recent travel history and had a strictly heterosexual and monogamous way of living. A full blood count displayed severe elevated liver enzymes. A CT of the abdomen was performed and revealed steatosis but no acute abdominal pathology. During admission, the patient developed signs of meningoencephalitis. A lumbar puncture was performed, and the cerebrospinal fluid revealed lymphocytic pleocytosis consistent with mild inflammation. Furthermore, hepatitis E was found in the blood and the definitive diagnosis was established. The patient gradually recovered and was discharged within 8 days of admission. To the best of our knowledge, we present the second case describing concomitant hepatitis and meningoencephalitis, resolving spontaneously and not giving rise to sequelae.


2021 ◽  
Vol 27 (3) ◽  
pp. 3901-3904
Author(s):  
Radka Komitova ◽  
◽  
Аni Kevorkyan ◽  
Еlitsa Golkocheva-Markova ◽  
Мaria Atanasova ◽  
...  

Autochthonous hepatitis E virus (HEV) infection is an increasingly recognized zoonosis in western countries. It is often asymptomatic but may cause severe illness, particularly in immunocompromised patients or those with underlying chronic liver diseases. Even less frequently, cases of acute failure have been reported. In this article, we describe a case of an immunocompetent patient who presented with symptomatic acute HEV hepatitis and progressed to acute liver failure. The patient was transferred to another hospital for further management and transplant consideration. Unfortunately, he developed multi-organ failure thereafter and died before the transplantation became feasible. Subsequently, HEV was confirmed in archived serum by detection of HEV RNA using commercial RT-PCR. The results of this study have confirmed that HEV testing should be included in the initial evaluation of every acute liver failure regardless of travel history, risk factors or underlying chronic liver diseases. This approach might support clinical decisions and enable to use of potential antiviral therapy.


Pathology ◽  
2015 ◽  
Vol 47 (2) ◽  
pp. 97-100 ◽  
Author(s):  
Ashish C. Shrestha ◽  
Helen M. Faddy ◽  
Robert L.P. Flower ◽  
Clive R. Seed ◽  
Anthony J. Keller

Author(s):  
W.L. Steffens ◽  
M.B. Ard ◽  
C.E. Greene ◽  
A. Jaggy

Canine distemper is a multisystemic contagious viral disease having a worldwide distribution, a high mortality rate, and significant central neurologic system (CNS) complications. In its systemic manifestations, it is often presumptively diagnosed on the basis of clinical signs and history. Few definitive antemortem diagnostic tests exist, and most are limited to the detection of viral antigen by immunofluorescence techniques on tissues or cytologic specimens or high immunoglobulin levels in CSF (cerebrospinal fluid). Diagnosis of CNS distemper is often unreliable due to the relatively low cell count in CSF (<50 cells/μl) and the binding of blocking immunoglobulins in CSF to cell surfaces. A more reliable and definitive test might be possible utilizing direct morphologic detection of the etiologic agent. Distemper is the canine equivalent of human measles, in that both involve a closely related member of the Paramyxoviridae, both produce mucosal inflammation, and may produce CNS complications. In humans, diagnosis of measles-induced subacute sclerosing panencephalitis is through negative stain identification of whole or incomplete viral particles in patient CSF.


1999 ◽  
Vol 4 (4) ◽  
pp. 4-4

Abstract Symptom validity testing, also known as forced-choice testing, is a way to assess the validity of sensory and memory deficits, including tactile anesthesias, paresthesias, blindness, color blindness, tunnel vision, blurry vision, and deafness—the common feature of which is a claimed inability to perceive or remember a sensory signal. Symptom validity testing comprises two elements: A specific ability is assessed by presenting a large number of items in a multiple-choice format, and then the examinee's performance is compared with the statistical likelihood of success based on chance alone. Scoring below a norm can be explained in many different ways (eg, fatigue, evaluation anxiety, limited intelligence, and so on), but scoring below the probabilities of chance alone most likely indicates deliberate deception. The positive predictive value of the symptom validity technique likely is quite high because there is no alternative explanation to deliberate distortion when performance is below the probability of chance. The sensitivity of this technique is not likely to be good because, as with a thermometer, positive findings indicate that a problem is present, but negative results do not rule out a problem. Although a compelling conclusion is that the examinee who scores below probabilities is deliberately motivated to perform poorly, malingering must be concluded from the total clinical context.


2007 ◽  
Vol 12 (2) ◽  
pp. 4-8
Author(s):  
Frederick Fung

Abstract A diagnosis of toxic-related injury/illness requires a consideration of the illness related to the toxic exposure, including diagnosis, causation, and permanent impairment; these are best performed by a physician who is certified by a specialty board certified by the American Board of Preventive Medicine. The patient must have a history of symptoms consistent with the exposure and disease at issue. In order to diagnose the presence of a specific disease, the examiner must find subjective complaints that are consistent with the objective findings, and both the subjective complaints and objective findings must be consistent with the disease that is postulated. Exposure to a specific potentially causative agent at a defined concentration level must be documented and must be sufficient to induce a particular pathology in order to establish a diagnosis. Differential diagnoses must be entertained in order to rule out other potential causes, including psychological etiology. Furthermore, the identified exposure at the defined concentration level must be capable of causing the diagnosis being postulated before the examiner can conclude that there has been a cause-and-effect relationship between the exposure and the disease (dose-response relationship). The evaluator's opinion should make biological and epidemiological sense. The treatment plan and prognosis should be consistent with evidence-based medicine, and the rating of impairment must be based on objective findings in involved systems.


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