PHM2 BUDGET IMPACT (Bl) OF PARENTERAL IRON TREATMENT OF IRON DEFICIENCY ANAEMIA (IDA) IN SWITZERLAND

AbstractOral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.

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PSY4 A SYSTEMATIC LITERATURE REVIEW AND INDIRECT COMPARISON OF IRON ISOMALTOSIDE AND FERRIC CARBOXYMALTOSE IN IRON DEFICIENCY ANAEMIA AFTER FAILURE OR INTOLERANCE OF ORAL IRON TREATMENT

Value in Health ◽

10.1016/j.jval.2019.04.1829 ◽

2019 ◽

Vol 22 ◽

pp. S374

Author(s):

R. Pollock ◽

G. Muduma

Keyword(s):

Iron Deficiency ◽

Literature Review ◽

Systematic Literature Review ◽

Iron Deficiency Anaemia ◽

Indirect Comparison ◽

Oral Iron ◽

Ferric Carboxymaltose ◽

Deficiency Anaemia ◽

Iron Treatment

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Budget impact of parenteral iron treatment of iron deficiency: methodological issues raised by using real-life data

The European Journal of Health Economics ◽

10.1007/s10198-013-0533-9 ◽

2013 ◽

Vol 15 (9) ◽

pp. 907-916 ◽

Cited By ~ 7

Author(s):

Elisabeth Brock ◽

Peter Braunhofer ◽

Josef Troxler ◽

Heinz Schneider

Keyword(s):

Iron Deficiency ◽

Budget Impact ◽

Real Life ◽

Methodological Issues ◽

Life Data ◽

Real Life Data ◽

Iron Treatment ◽

Parenteral Iron

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Comparative study of efficacy and safety of parenteral iron sucrose versus ferric carboxymaltose in treatment of postpartum iron deficiency anaemia

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20215083 ◽

2021 ◽

Vol 11 (1) ◽

pp. 100

Author(s):

Ganesh N. Dakhle ◽

Mrunalini V. Kalikar ◽

Rujuta P. Fuke ◽

Anisha S. Parmarthi ◽

Mrunalini K. Chokhandre

Keyword(s):

Iron Deficiency ◽

Serum Ferritin ◽

Iron Deficiency Anaemia ◽

Maximum Dose ◽

Iron Sucrose ◽

Ferric Carboxymaltose ◽

Care Hospital ◽

Deficiency Anaemia ◽

Iron Stores ◽

Parenteral Iron

Background: Postpartum anaemia often leads to multiple clinical complications in mother as well as infant and iron supplementation with parenteral iron is the preferred treatment modality. The present study was planned to compare the efficacy and tolerability of IV iron sucrose and IV ferric carboxymaltose in treatment of postpartum iron deficiency anaemia.Methods: This randomized, parallel, open label, prospective 4-weeks study was conducted from June 2019 to December 2020 in women with postpartum anaemia admitted to obstetrics and gynaecology inpatient department of a tertiary care hospital. Women with postpartum iron deficiency anaemia (N=60) were randomly divided into two groups; receiving Injection iron sucrose (N=30, maximum dose 500 mg) or Injection ferric carboxymaltose (N=30, maximum dose 500 mg). Change in haemoglobin and serum ferritin levels from baseline to the end of 2 and 4 weeks of treatment were evaluated.Results: The results showed early, sustained and significant increase in the haemoglobin levels in both the groups. However, the difference was not significant between groups (p=0.2). Evaluation of replenishment of iron stores (serum ferritin) showed improvement in both the groups, however in FCM group the rise was found to be significant (p<0.05).Conclusions: FCM in a lower dose of 500mg was found to be safe and effective in significantly improving haemoglobin concentration as well as in replenishing iron stores in patients with postpartum anaemia.

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