Long-term memory cellular immune response to dengue virus after a natural primary infection

The effectiveness of rabies vaccines is conventionally determined by serological testing. In addition to this assessment of humoral immunity, cellular immunity could help assess effectiveness and protection through a broad range of parameters. Therefore, this study aimed to systematically review all literature on the kinetics and composition of the cellular immune response to rabies vaccination in humans. A total of 1360 studies were identified in an extensive literature search. Twenty studies were selected for inclusion. In a primary response, plasma cells are detectable from day 7 to day 14, peaking at day 10. Memory B-cells appear from day 10 up to at least day 28. After revaccination, natural killer (NK) cells are the first detectable cellular parameters. Further research is required to assess cellular parameters in relation to long-term (serological) immunity. This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42019134416.

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The Cellular Immune Response Plays an Important Role in Protecting Against Dengue Virus in the Mouse Encephalitis Model

Viral Immunology ◽

10.1089/vim.2008.0063 ◽

2009 ◽

Vol 22 (1) ◽

pp. 23-30 ◽

Cited By ~ 33

Author(s):

Lázaro Gil ◽

Carlos López ◽

Aracelys Blanco ◽

Laura Lazo ◽

Jorge Martín ◽

...

Keyword(s):

Immune Response ◽

Dengue Virus ◽

Cellular Immune Response ◽

Cellular Immune

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Long-term administration of galactoside-specific mistletoe lectin in an animal model: no protection against N -butyl- N -(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis in rats and no induction of a relevant local cellular immune response

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s004320050022 ◽

2000 ◽

Vol 126 (3) ◽

pp. 125-138 ◽

Cited By ~ 18

Author(s):

E. Kunze ◽

H. Schulz ◽

M. Adamek ◽

H.-J. Gabius

Keyword(s):

Immune Response ◽

Animal Model ◽

Urinary Bladder ◽

Cellular Immune Response ◽

Mistletoe Lectin ◽

Bladder Carcinogenesis ◽

Term Administration ◽

Cellular Immune

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Detection of long term cellular immune response to Japanese encephalitis vaccination using IFN-γ ELIspot assay

Journal of Medical Virology ◽

10.1002/jmv.24893 ◽

2017 ◽

Vol 89 (12) ◽

pp. 2235-2238

Author(s):

Amreen Zia ◽

Dharamveer Singh ◽

Swati Saxena ◽

Jyoti Umrao ◽

Manjari Baluni ◽

...

Keyword(s):

Immune Response ◽

Japanese Encephalitis ◽

Cellular Immune Response ◽

Elispot Assay ◽

Ifn Γ ◽

Cellular Immune

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Nippostrongylus brasiliensis: observations on factors affecting the establishment of secondary worm populations in rats

Parasitology ◽

10.1017/s0031182000045327 ◽

1974 ◽

Vol 68 (1) ◽

pp. 13-17 ◽

Cited By ~ 6

Author(s):

D. Conwil Jenkins

Keyword(s):

Immune Response ◽

Cellular Immune Response ◽

Primary Infection ◽

Host Immunity ◽

Acquired Immunity ◽

Nippostrongylus Brasiliensis ◽

Factors Affecting ◽

Repeated Doses ◽

Per Se ◽

Cellular Immune

Previously immunized rats of different ages were exposed either to one large, or several small challenge infections with the nematode, Nippostrongylus brasiliensis. The number of secondary worms harboured by each of these rats was then determined on the fourteenth day after exposure to challenge. It was found that worms adapted more efficiently to host immunity when both (a) the rats were less than 11 weeks old when challenged and (b) the challenge was given in small repeated doses over a period of weeks. The age of the rats on exposure to the immunizing primary infection, however, had little or no affect per se on the subsequent establishment of immune-adapted worms. It is tentatively suggested that the failure of worms to adapt effectively to the acquired immunity of older rats resulted from the acquisition by these rats of a fully competent cellular immune response.

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