scholarly journals OL-085 A candidate genes study for the association of host single nucleotide polymorphisms with liver cirrhosis risk in Chinese hepatitis B patients

2011 ◽  
Vol 15 ◽  
pp. S44
Author(s):  
L.J. Peng ◽  
J.S. Guo ◽  
Z. Zhang ◽  
L.L. Liu ◽  
Y.R. Cao ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals IL17A gene polymorphisms: relationship to predisposition for chronic viral hepatitis and progression to liver cirrhosis in kazakh population

2016 ◽  
Vol 61 (5) ◽  
pp. 212-219
Author(s):  
M. R. Massabayeva ◽  
N. E. Aukenov ◽  
Zh. B. Mussazhanova ◽  
V. A. Saenko ◽  
T. I. Rogounovitch ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Viral Hepatitis ◽  
Association Study ◽  
Chronic Viral Hepatitis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Kazakh Population

Introduction. This work is the first genetic association study of a potential relationship of single nucleotide polymorphisms rs8193036 and rs2275913 located in the IL17A promoter on chromosome 6p12 to chronic viral hepatitis and its progression in Kazakh population. Purpose. Evaluation of the effect of IL17A polymorphism on predisposition for chronic hepatitis B and C and its progression to liver cirrhosis. Material and methods. A total of 862 individuals were enrolled in the retrospective case-control association study. Among the participants, 100 patients had chronic hepatitis B and/or C and liver cirrhosis, and 341 patients had chronic viral hepatitis only. Four hundred twenty-one (421) healthy HBV- and HCV-negative donors without liver diseases were recruited as population control. single nucleotide polymorphisms rs8193036[T/C] and rs2275913[G/A] were genotyped by TaqMan assays using genomic DNA extracted from peripheral blood cells. Results. Minor allele frequencies of rs8193036[C] and rs2275913[A] in the groups of patients were very similar to those observed in the control population, 0.4 and 0.3, respectively. Multivariate logistic regression analysis revealed odds ratios close to 1.0 and confidence intervals overlapping with the value of 1.0 and statistical significance p > 0.4 for any groups under comparison in the multiplicative model of inheritance. Conclusion. No significant association between two single nucleotide polymorphisms, rs8193036 and rs2275913 in the IL17A promoter, and susceptibility to chronic viral hepatitis C and/or B and disease progression to liver cirrhosis in Kazakh population were found.

scholarly journals Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yang Zhuo ◽  
Yalan Yang ◽  
Mingjun Zhang ◽  
Ying Xu ◽  
Zhongping Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Signaling Pathway ◽  
Public Health Problem ◽  
Hbv Infection ◽  
Nucleotide Polymorphisms ◽  
Breakthrough Infection ◽  
Single Nucleotide ◽  
B Virus

Hepatitis B virus (HBV) infection is a challenging public health problem in China and worldwide. Mother-to-child transmission is one of the main transmission routes of HBV in highly endemic regions. However, the mechanisms of HBV perinatal transmission in children have not been clearly defined. The aim of this study was to demonstrate the association between single-nucleotide polymorphisms (SNPs) in IFN-γ signaling pathway and HBV infection or breakthrough infection in children. Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. SNPs in IFN-γ signaling pathway including IFNG, IFNGR1, IFNGR2, and IL12B were genotyped. Rs2234711 in IFNGR1 was significantly associated with HBV infection in children (OR = 0.641, 95% CI: 0.450–0.913). In addition, rs2234711 was also significantly associated with HBV breakthrough infection in children born to HBsAg-positive mothers (OR = 0.452, 95% CI: 0.205–0.998). Our study confirmed that genetic variants in IFN-γ signaling pathway have significant associations with HBV infection, especially with HBV breakthrough in children. This study provides insight into HBV infection in children and could be used to help design effective strategies for reducing immunoprophylaxis failure.

scholarly journals Single nucleotide polymorphisms in CXCR1 gene and its association with hepatitis B infected patients in Saudi Arabia

2013 ◽  
Vol 12 (2) ◽  
pp. 220-227 ◽  
Author(s):  
Fahad N. Almajhdi ◽  
Mohammed Al-Ahdal ◽  
Ayman A. Abdo ◽  
Faisal M. Sanai ◽  
Mashael Al-Anazi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Association studies of multiple candidate genes for Parkinson's Disease using single nucleotide polymorphisms

2002 ◽  
Vol 51 (4) ◽  
pp. 534-534 ◽  
Author(s):  
Yoshio Momose ◽  
Miho Murata ◽  
Kazuhiro Kobayashi ◽  
Masaji Tachikawa ◽  
Yuko Nakabayashi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Association Studies ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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