Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: longitudinal evaluation of a cohort of prospective brain donors

2002 ◽  
Vol 9 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Charles H. Adler ◽  
Joseph G. Hentz ◽  
Jeffrey N. Joyce ◽  
Thomas Beach ◽  
John N. Caviness
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Impairment ◽  
Normal Aging ◽  
Longitudinal Evaluation

scholarly journals Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory Dance Learning over 3-Years: A Preliminary Longitudinal Investigation

2021 ◽  
Vol 11 (7) ◽  
pp. 895
Author(s):  
Karolina A. Bearss ◽  
Joseph F. X. DeSouza
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Daily Living ◽  
Rating Scale ◽  
Motor Impairment ◽  
Motor Dysfunction ◽  
Motor Symptom ◽  
Significant Group ◽  
Rate Of Decline ◽  
Symptom Progression

Parkinson’s disease (PD) is a neurodegenerative disease that has a fast progression of motor dysfunction within the first 5 years of diagnosis, showing an annual motor rate of decline of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) between 5.2 and 8.9 points. We aimed to determine both motor and non-motor PD symptom progression while participating in dance classes once per week over a period of three years. Longitudinal data was assessed for a total of 32 people with PD using MDS-UPDRS scores. Daily motor rate of decline was zero (slope = 0.000146) in PD-Dancers, indicating no motor impairment, whereas the PD-Reference group showed the expected motor decline across three years (p < 0.01). Similarly, non-motor aspects of daily living, motor experiences of daily living, and motor complications showed no significant decline. A significant group (PD-Dancers and PD-Reference) by days interaction showed that PD who train once per week have less motor impairment (M = 18.75) than PD-References who do not train (M = 24.61) over time (p < 0.05). Training is effective at slowing both motor and non-motor PD symptoms over three years as shown in decreased scores of the MDS-UPDRS.

Neural Precursors Derived from Embryonic and Mesenchymal Stem Cells Ameliorate Parkinson's Disease Associated Motor Impairment

2019 ◽  
Vol 254 ◽  
pp. 148
Author(s):  
Nazaret Gamez Ruiz ◽  
George A Edwards ◽  
Priyadarshini Peter ◽  
Enrique Antonio Armijo Fuentes ◽  
Carlos Kramm Barria ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Motor Impairment ◽  
Neural Precursors

scholarly journals EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease

2020 ◽  
Vol 12 ◽  
Author(s):  
Vitalii V. Kozak ◽  
Menorca Chaturvedi ◽  
Ute Gschwandtner ◽  
Florian Hatz ◽  
Antonia Meyer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Impairment

scholarly journals Report from a multidisciplinary meeting on anxiety as a non-motor manifestation of Parkinson’s disease

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Gregory M. Pontone ◽  
Nadeeka Dissanayaka ◽  
Liana Apostolova ◽  
Richard G. Brown ◽  
Roseanne Dobkin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Expert Panel ◽  
Motor Impairment ◽  
Future Research ◽  
Severe Problem ◽  
High Prevalence ◽  
Expert Meeting ◽  
Clinician Scientist

AbstractAnxiety is a severe problem for at least one-third of people living with Parkinson’s disease (PD). Anxiety appears to have a greater adverse impact on quality of life than motor impairment. Despite its high prevalence and impact on daily life, anxiety is often undiagnosed and untreated. To better address anxiety in PD, future research must improve knowledge about the mechanism of anxiety in PD and address the lack of empirical evidence from clinical trials. In response to these challenges, the Parkinson’s Foundation sponsored an expert meeting on anxiety on June 13th and 14th 2018. This paper summarizes the findings from that meeting informed by a review of the existing literature and discussions among patients, caregivers, and an international, clinician-scientist, expert panel working group. The goal is to provide recommendations to improve our understanding and treatment of anxiety in PD.

Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

2012 ◽  
Vol 45 (3) ◽  
pp. 1051-1067 ◽  
Author(s):  
Natalie R.S. Goldberg ◽  
Victoria Fields ◽  
Lacey Pflibsen ◽  
Michael F. Salvatore ◽  
Charles K. Meshul
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Motor Impairment

scholarly journals Dopaminergic Receptors on CD4+ T Naive and Memory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson’s Disease

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Natasa Kustrimovic ◽  
Emanuela Rasini ◽  
Massimiliano Legnaro ◽  
Raffaella Bombelli ◽  
Iva Aleksic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Impairment ◽  
Dopaminergic Receptors ◽  
Memory Lymphocytes

scholarly journals Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging

1996 ◽  
Vol 40 (6) ◽  
pp. 873-884 ◽  
Author(s):  
Kirk A. Frey ◽  
Robert A. Koeppe ◽  
Michael R. Kilbourn ◽  
Thierry M. Vander Borght ◽  
Roger L. Albin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Normal Aging
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