Breast cancer with synchronous metastases: trends in survival over a 14-year period

2004 ◽  
Vol 2 (3) ◽  
pp. 138
Author(s):  
F Andre ◽  
K Slimane ◽  
T Bachelot ◽  
M Namer ◽  
S Delaloge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Synchronous Metastases

scholarly journals Risk of Synchronous Distant Recurrence at Time of Locoregional Recurrence in Patients With Stage II and III Breast Cancer (AFT-01)

2018 ◽  
Vol 36 (10) ◽  
pp. 975-980 ◽  
Author(s):  
Heather B. Neuman ◽  
Jessica R. Schumacher ◽  
Amanda B. Francescatti ◽  
Taiwo Adesoye ◽  
Stephen B. Edge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Chest Wall ◽  
Locoregional Recurrence ◽  
Distant Metastases ◽  
Distant Recurrence ◽  
Stage Ii ◽  
Factors Associated ◽  
Increased Risk ◽  
Synchronous Metastases

Purpose National Comprehensive Cancer Network guidelines recommend systemic staging imaging at the time of locoregional breast cancer recurrence. Limited data support this recommendation. We determined the rate of synchronous distant recurrence at the time of locoregional recurrence in high-risk patients and identified clinical factors associated with an increased risk of synchronous metastases. Methods A stage-stratified random sample of 11,046 patients with stage II to III breast cancer in 2006 to 2007 was selected from the National Cancer Database for participation in a Commission on Cancer special study. From medical record abstraction of imaging and recurrence data, we identified patients who experienced locoregional recurrence within 5 years of diagnosis. Synchronous distant metastases (within 30 days of locoregional recurrence) were determined. We used multivariable logistic regression to identify factors associated with synchronous metastases. Results Four percent experienced locoregional recurrence (n = 445). Synchronous distant metastases were identified in 27% (n = 120). Initial presenting stage ( P = .03), locoregional recurrence type ( P = .01), and insurance status ( P = .03) were associated with synchronous distant metastases. The proportion of synchronous metastases was highest for women with lymph node (35%), postmastectomy chest wall (30%), and in-breast (15%) recurrence; 54% received systemic staging imaging within 30 days of a locoregional recurrence. Conclusion These findings support current recommendations for systemic imaging in the setting of locoregional recurrence, particularly for patients with lymph node or chest wall recurrences. Because most patients with isolated locoregional recurrence will be recommended locoregional treatment, early identification of distant metastases through routine systemic imaging may spare them treatments unlikely to extend their survival.

Prevalence of synchronous metastases of breast cancer depends both on tumor subtypes and tumor burden.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 1096-1096 ◽  
Author(s):  
C. Boutros ◽  
C. Mazouni ◽  
M. Saghatchian ◽  
J. Domont ◽  
C. Balleyguier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Burden ◽  
Tumor Subtypes ◽  
Synchronous Metastases

scholarly journals Survival after bone metastasis by primary cancer type: a Danish population-based cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e016022 ◽  
Author(s):  
Elisabeth Svensson ◽  
Christian F Christiansen ◽  
Sinna P Ulrichsen ◽  
Mikael R Rørth ◽  
Henrik T Sørensen
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Bone Metastases ◽  
Population Based ◽  
Solid Cancer ◽  
Cancer Type ◽  
Adjusted Relative Risk ◽  
Primary Cancer ◽  
Cancer Types ◽  
Synchronous Metastases

ObjectiveIn the 10 most common primary types with bone metastases, we aimed to examine survival, further stratifying on bone metastases only or with additional synchronous metastases.MethodsWe included all patients aged 18 years and older with incident hospital diagnosis of solid cancer between 1994 and 2010, subsequently diagnosed with BM until 2012. We followed patients from date of bone metastasis diagnosis until death, emigration or 31 December 2012, whichever came first. We computed 1-year, 3-year and 5-year survival (%) and the corresponding 95% CIs stratified on primary cancer type. Comparing patients with bone metastasis only and patients with other synchronous metastases, we estimated crude and adjusted HRs and corresponding 95% CI for mortality.ResultsWe included 17 251 patients with bone metastasis. The most common primary cancer types with bone metastasis were prostate (34%), breast (22%) and lung (20%). One-year survival after bone metastasis diagnosis was lowest in patients with lung cancer (10%, 95% CI 9% to 11%) and highest in patients with breast cancer (51%, 50% to 53%). At 5 years of follow-up, only patients with breast cancer had over 10% survival (13%, 11% to 14%). The risk of mortality was increased for the majority of cancer types among patients with bone and synchronous metastases compared with bone only (adjusted relative risk 1.29–1.57), except for cervix, ovarian and bladder cancer.ConclusionsWhile patients with bone metastases after most primary cancers have poor survival, one of ten patients with bone metastasis from breast cancer survived 5 years.

Breast Cancer With Synchronous Metastases: Survival Impact of Exclusive Locoregional Radiotherapy

2009 ◽  
Vol 27 (9) ◽  
pp. 1375-1381 ◽  
Author(s):  
Romuald Le Scodan ◽  
Denise Stevens ◽  
Etienne Brain ◽  
Jean Louis Floiras ◽  
Christine Cohen-Solal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multivariate Analysis ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Alternative Form ◽  
Breast Cancer Patients ◽  
Group A ◽  
Synchronous Metastases ◽  
Group B ◽  
The Impact

Purpose Several studies suggest that surgical excision of the primary tumor improves survival among patients with stage IV breast cancer at diagnosis. Exclusive locoregional radiotherapy (LRR) is an alternative form of locoregional treatment (LRT) in this setting. We retrospectively studied the impact of LRT on the survival of breast cancer patients with synchronous metastases. Patients and Methods Among 18,753 breast cancer patients treated in our institution between 1980 and 2004, 598 patients (3.2%) had synchronous metastasis at diagnosis. Demographic data, tumor characteristics, metastatic sites, and treatments were prospectively recorded. The impact of LRT on overall survival (OS) was evaluated by multivariate analysis including known prognostic factors. Results Among 581 eligible patients, 320 received LRT (group A), and 261 received no LRT (group B). LRT consisted of exclusive LRR in 249 patients (78%), surgery of the primary tumor with adjuvant LRR in 41 patients (13%), and surgery alone in 30 patients (9%). With a median follow-up time of 39 months, the 3-year OS rates were 43.4% and 26.7% in group A and group B (P =.00002), respectively. The association between LRT and improved survival was particularly marked in women with visceral metastases. LRT was an independent prognostic factor in multivariate analysis (hazard ratio [HR] = 0.70; 95% CI, 0.58 to 0.85; P = .0002). The adjusted HR for late death (≥ 1 year) was 0.76 (95% CI, 0.61 to 0.96; P = .02). Conclusion In our experience, LRT, consisting mainly of exclusive LRR, was associated with improved survival in breast cancer patients with synchronous metastases. Exclusive LRR may thus represent an active alternative to surgery.

Breast cancer with synchronous metastases: Impact of locoregional radiotherapy (LRR) on survival

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 1038-1038
Author(s):  
R. Le Scodan ◽  
D. Stevens ◽  
M. Tubiana-Hulin ◽  
B. De La Lande ◽  
C. Cohen-Solal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Synchronous Metastases

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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