8532 Prognostic impact of comorbidity in elderly patients with head and neck squamous cell carcinoma (HNSCC)

2009 ◽  
Vol 7 (2) ◽  
pp. 480
Author(s):  
M.A. Moreno Jimenez ◽  
I. Gonzalez Cebrian ◽  
R. Collado Martin ◽  
B. Medina Magan ◽  
A.L. Ortega Granados ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Elderly Patients ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Impact

scholarly journals Prospective Evaluation of XRCC-1 as a Biopredictor for Survival Outcomes in Patients of Head and Neck Squamous Cell Carcinoma (HNSCC): A Meta-analysis

2021 ◽  
Author(s):  
Fan Yang ◽  
Liu-qing Zhou ◽  
Yan-jun Wang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Neck Squamous Cell Carcinoma ◽  
Survival Outcomes ◽  
Prognostic Impact ◽  
Meta Analyses

Abstract Background: Epidemiologic studies have demonstrated that X-ray repair cross-complementary group 1 (XRCC1) is one of the susceptibility factors in head and neck squamous cell carcinoma(HNSCC) patients. However, its clinical prognostic impact remains controversial. Thus, a meta-analysis was performed to clarify the survival value of XRCC1 in HNSCC patients.Methods: Following the Preferred Reporting Items or Systematic Reviews Meta Analyses (PRISMA) 2020 guidelines, literature searches were systematically performed by PubMed, EMBASE and Web of Science with a manual retreive to evaluate the prognostic consequence of XRCC1 in HNSCC patients. Hazard ratios (HRs) and 95% confidence intervals (CIs) were collected to estimate the correlation between XRCC1 and the survival outcomes of HNSCC patients.Results: Ten studies including 2086 HNSCC patients who satisfied the inclusion and exclusion criteria were included in this meta-analysis. The meta-analysis showed that high XRCC1 expression and Arg399Gln and Arg194Trp were significantly correlated with poorer overall survival (OS), with HRs of 1.97 (95% CI, 1.36–2.84, P<0.001), 1.30 (95% CI, 1.12–1.51, P<0.001), and 1.65 (95% CI, 1.18–2.32 P<0.05), respectively.Conclusion: XRCC1 was associated with poorer survival outcomes in HNSCC patients. Hence, XRCC1 is a potential therapeutic target for HNSCC.

Prognostic impact of socioeconomic status compared to overall stage for HPV-negative head and neck squamous cell carcinoma

Oral Oncology ◽  
2021 ◽  
Vol 119 ◽  
pp. 105377
Author(s):  
Nicholas R. Lenze ◽  
Douglas R. Farquhar ◽  
Siddharth Sheth ◽  
Jose P. Zevallos ◽  
Catherine Lumley ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Impact

Cetuximab-Carboplatin-5-Fluorouracil Regimen in Elderly Patients with Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma: A French Retrospective Survey

Oncology ◽  
2017 ◽  
Vol 93 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Mickaël Burgy ◽  
Philippe Barthélémy ◽  
François Lefevre ◽  
Agnès Dupret-Bories ◽  
Pierre Truntzer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Elderly Patients ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Retrospective Survey

Treatment of head and neck squamous cell carcinoma in elderly patients

Toukeibu Gan ◽  
2010 ◽  
Vol 36 (4) ◽  
pp. 502-506
Author(s):  
Keigo Honda Keigo Honda ◽  
Ryo Asato Ryo Asato ◽  
Jun Tsuji Jun Tsuji ◽  
Tomoko Kanda Tomoko Kanda ◽  
Kohji Ushiro Kohji Ushiro ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Elderly Patients ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

scholarly journals The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 418
Author(s):  
Helene Hersvik Aarstad ◽  
Svein Erik Emblem Moe ◽  
Øystein Bruserud ◽  
Stein Lybak ◽  
Hans Jørgen Aarstad ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Acute Phase ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Impact ◽  
Phase Reaction ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction inducers. In the present study, we compared the pretreatment acute phase cytokine profile for 144 patients with potentially curative HNSCC. We investigated the systemic levels of interleukin (IL)6 family mediators (glycoprotein (gp130), IL6 receptor (R)α, IL6, IL27, IL31, oncostatin M (OSM), ciliary neurotrophic factor (CNTF)), IL1 subfamily members (IL1R antagonist (A), IL33Rα), and tumor necrosis factor (TNF)α. Patient subsets identified from this 10-mediator profile did not differ with regard to disease stage, human papilloma virus (HPV) status, CRP levels, or death cause. Increased CRP, IL6, and IL1RA levels were independent markers for HNSCC-related death in the whole patient population. Furthermore, gp130, IL6Rα, and IL31 were suggested to predict prognosis among tumor HPV-negative patients. Only IL6 predicted survival in HPV-positive patients. Finally, we did a clustering analysis of HPV-negative patients based on six acute phase mediators that showed significant or borderline association with prognosis in Kaplan–Meier analyses; three subsets could then be identified, and they differed in survival (p < 0.001). To conclude, (i) HPV-negative and HPV-positive HNSCC patients show similar variations of their systemic acute phase profiles; (ii) the prognostic impact of single mediators differs between these two patient subsets; and (iii) for HPV-negative patients, acute phase profiling identifies three patient subsets that differ significantly in survival.

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