EEG and long-term outcome of term infants with neonatal hypoxic-ischemic encephalopathy

Background: The aim of the study was to find out the neurodevelopmental outcome of babies with hypoxic ischemic encephalopathy at 6 months of age and to predict early markers of abnormal neurological outcome in those babies.Methods: 50 babies admitted with hypoxic ischemic encephalopathy were enrolled in this prospective study and followed up at 3 and 6 months of age at Mahatma Gandhi Memorial Government Hospital, Trichy. The neurological outcome of the babies was assessed by CDC grading of motor milestones, Trivandrum development screening chart, Amiel Tison angles head circumference and weight measured. USG cranium was done for all the babies and MRI brain was done in babies with abnormal neuro sonogram and abnormal outcome. Vision and hearing were tested clinically.Results: The incidence of abnormal neurological outcome was 14%. The early markers predicting abnormal neurological sequele are identified.Conclusions: Early identification of abnormal neuro behaviour helps in starting early intervention to improve the long term outcome.

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Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy

Pediatric Nephrology ◽

10.1007/s00467-019-04406-4 ◽

2019 ◽

Vol 35 (3) ◽

pp. 477-483 ◽

Cited By ~ 2

Author(s):

Francesco Cavallin ◽

Giulia Rubin ◽

Enrico Vidal ◽

Elisa Cainelli ◽

Luca Bonadies ◽

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Keyword(s):

Acute Kidney Injury ◽

Kidney Injury ◽

Hypoxic Ischemic Encephalopathy ◽

Prognostic Role ◽

Term Outcome ◽

Long Term Outcome ◽

Ischemic Encephalopathy

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Prognostic Markers in Term Infants with Hypoxic–Ischemic Encephalopathy: Comparative Analysis of MRI, EEG, and Apgar Scores

Journal of Pediatric Neurology ◽

10.1055/s-0037-1606367 ◽

2017 ◽

Vol 16 (01) ◽

pp. 008-014 ◽

Cited By ~ 1

Author(s):

Elissa Yozawitz ◽

Ajay Goenka

Keyword(s):

Hypoxic Ischemic Encephalopathy ◽

Neurological Deficits ◽

Term Infants ◽

Term Outcome ◽

Apgar Scores ◽

Long Term Outcome ◽

Perinatally Acquired ◽

Magnetic Resonance Imaging Mri ◽

Poor Outcomes ◽

Ischemic Encephalopathy

AbstractHypoxic–ischemic encephalopathy (HIE) is a frequent cause of perinatally acquired brain injury resulting in abnormal neurological consequences. In this retrospective study, we evaluated 68 neonates with clinical evidence of HIE to investigate the utility of magnetic resonance imaging (MRI), electroencephalography (EEG), and Apgar scores, individually and in combination, as predictors of long-term outcome. Six infants died during treatment, and 46 of the remaining 62 infants (74%) received follow-up neurological assessments at ages 6 to 24 months. The outcome was dichotomously classified as good (reflecting “normal development”) or as poor (reflecting “neurological deficits” based upon attainment of developmental milestones or death). Abnormal Apgar scores, MRIs, and EEGs had sensitivities of 50, 84, and 95% for predicting “neurological deficit.” Corresponding specificities were 85, 66, and 18%. However, the combination of abnormal Apgar scores, MRIs, and EEGs in predicting poor outcomes (i.e., “neurological deficits” or death) had sensitivity and specificity of 100%. In addition, the combination of abnormal Apgar scores, MRIs, and EEGs provided a positive predictive value of 100% in assessing poor outcome as compared with 73% (p = 0.2) for Apgar scores, 71% (p = 0.01) for MRIs, and 56% (p = 0.001) for EEGs.

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