219 EXPRESSION OF ANGIOTENSIN II TYPE 1 (AT1) AND TYPE 2 (AT2) RECEPTORS AFTER SLEEP DEPRIVATION AND SLEEP RESTRICTION

2009 ◽  
Vol 10 ◽  
pp. S59
Author(s):  
J.C. Perry ◽  
C.T. Bergamaschi ◽  
R.R. Campos ◽  
S. Tufik
Keyword(s):  
Angiotensin Ii ◽  
Sleep Deprivation ◽  
Sleep Restriction ◽  
At2 Receptors

Expression of Angiotensin II Type 1 and Type 2 Receptor in Human Myocardium with Congestive Heart Failure

2000 ◽  
Vol 6 (S2) ◽  
pp. 618-619
Author(s):  
P. Y. Lau ◽  
M. G. Cardarelli ◽  
C. Wei
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Angiotensin Ii ◽  
Cardiac Tissue ◽  
Open Heart Surgery ◽  
Human Myocardium ◽  
Receptor Expression ◽  
At2 Receptors

Angiotensin II (AH) is a potent vasoconstrictor and mitogenic factor. AH receptors include type 1 (ATI) and type 2 (AT2) receptors. Recent studies demonstrated that both ATI and AT2 receptors expressed in human myocardium. Circulating and local tissue level of AH was increased in severe congestive heart failure (CHF). However, the expression of ATI and AT2 in cardiac tissue with CHF remains controversial. Therefore, the present study was designed to investigate the protein expression of ATI and AT2 receptors in normal human myocardium and in human cardiac tissue with mild and severe CHF.Human atrial tissues from normal subjects and CHF patients with ischemic cardiomyopathy and dilated cardiomyopathy were obtained from open-heart surgery and cardiac transplantation. ATI and AT2 receptor expression was investigated by immunohistochemical staining (IHCS). The results of IHCS was evaluated by IHCS staining density scores (0, no staining; 1, minimal staining; 2, mild staining; 3, moderate staining; and 4, strong staining).

Expression of angiotensin II type 1 (AT1) and angiotensin II type 2 (AT2) receptors in human granulosa-lutein (GL) cells: correlation with infertility diagnoses

2010 ◽  
Vol 93 (5) ◽  
pp. 1601-1608 ◽  
Author(s):  
Óscar Peña ◽  
Angela Palumbo ◽  
Rebeca González-Fernández ◽  
Jairo Hernández ◽  
Frederick Naftolin ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
At2 Receptors

scholarly journals Role of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in airway reactivity and inflammation in an allergic mouse model of asthma

2019 ◽  
Vol 41 (3) ◽  
pp. 428-437 ◽  
Author(s):  
Mehaben Patel ◽  
Mangesh Kurade ◽  
Sahith Rajalingam ◽  
Riya Bhavsar ◽  
S. Jamal Mustafa ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Mouse Model ◽  
Airway Reactivity ◽  
Allergic Mouse ◽  
At2 Receptors

Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina

Neuroscience ◽  
2009 ◽  
Vol 161 (1) ◽  
pp. 195-213 ◽  
Author(s):  
L.E. Downie ◽  
K. Vessey ◽  
A. Miller ◽  
M.M. Ward ◽  
M.J. Pianta ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Glial Cell ◽  
Rat Retina ◽  
Cell Expression ◽  
At2 Receptors

Blockade of central angiotensin II type 1 and type 2 receptors suppresses adrenalectomy-induced NaCl intake in rats

1996 ◽  
Vol 66 (1-2) ◽  
pp. 47-50 ◽  
Author(s):  
O. Galaverna ◽  
C. Polidori ◽  
R.R. Sakai ◽  
F. Liénard ◽  
S.Y. Chow ◽  
...  
Keyword(s):  
Angiotensin Ii

Angiotensin II-induced thirst, but not sodium appetite, via AT1 receptors in organum cavum prelamina terminalis

1995 ◽  
Vol 268 (6) ◽  
pp. R1401-R1405 ◽  
Author(s):  
M. el Ghissassi ◽  
S. N. Thornton ◽  
S. Nicolaidis
Keyword(s):  
Angiotensin Ii ◽  
Salt Intake ◽  
High Sensitivity ◽  
Ang Ii ◽  
Nacl Solution ◽  
At1 Receptors ◽  
Sodium Appetite ◽  
Specific Antagonist

The angiotensin receptor specificity, with respect to fluid intake, of the organum cavum prelamina terminalis (OCPLT), a recently discovered discrete forebrain structure with high sensitivity to angiotensin II (ANG II), was investigated. ANG II (10 ng) microinjected into the OCPLT significantly increased water consumption but did not induce intake of a hypertonic (3%) NaCl solution. Losartan, an ANG II type 1 (AT1) receptor-specific antagonist, produced dose-related (1-100 ng) inhibition of ANG II-induced drinking. The ANG II type 2 receptor-specific antagonist CGP-42112A was ineffective. Intake of the 3% NaCl solution in response to microinjection of either of the antagonists into the OCPLT was never observed. These findings suggest that water intake produced by microinjection of ANG II into the OCPLT is mediated by AT1 receptors uniquely and that, in contrast to other regions of the brain, these receptors do not induce salt intake when stimulated by ANG II.

Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: An in vitro gene transfer study

Life Sciences ◽  
1998 ◽  
Vol 63 (19) ◽  
pp. PL289-PL295 ◽  
Author(s):  
Takehiko Yamada ◽  
Masahiro Akishita ◽  
Matthew J. Pollman ◽  
Gary H. Gibbons ◽  
Victor J. Dzau ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Gene Transfer ◽  
Cell Apoptosis ◽  
Receptor Action ◽  
Muscle Cell Apoptosis ◽  
Transfer Study

Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin

1993 ◽  
Vol 264 (5) ◽  
pp. R917-R923 ◽  
Author(s):  
D. A. Scheuer ◽  
M. H. Perrone
Keyword(s):  
Pressor Response ◽  
Pressure Response ◽  
Receptor Blockade ◽  
At1 Receptors ◽  
Angiotensin Iii ◽  
Depressor Action ◽  
Angiotensin Type ◽  
At2 Receptors

Angiotensin (ANG) can produce a biphasic arterial pressure response, i.e., an increase followed by a decrease. Because ANG type 1 (AT1) receptors mediate the pressor response to ANG, we hypothesized that the opposing depressor action is mediated by the ANG type 2 (AT2) receptors. In thiobutabarbital (Inactin)-anesthetized rats bolus injections of angiotensin III (ANG III; 100, 300, and 1,000 ng/kg iv) produced peak increases in MAP at 20 s of 13.4 +/- 1.4, 20.1 +/- 2, and 27.5 +/- 2.8 mmHg and maximum decreases in pressure at 120 s of -6.3 +/- 1.5, -6.8 +/- 2.2, and -11.4 +/- 4.9 mmHg. During blockade of the AT1 receptors with DuP 753 (losartan, 10 mg/kg) the increases in MAP were eliminated (P < 0.01), whereas the depressor responses (-24.7 +/- 8, -32.8 +/- 9.3, and -42.0 +/- 10.0 mmHg) were significantly (P < 0.05) larger. In separate groups of rats, combined blockade of both AT1 and AT2 receptors eliminated all changes in MAP in response to ANG III, whereas blockade of AT2 receptors alone enhanced the pressor response to ANG III. During AT1 receptor blockade angiotensin II also caused consistent decreases in pressure, which were inhibited during combined blockade of AT1 and AT2 receptors. Therefore, we have demonstrated that the AT2 receptors mediate a depressor response to ANG.

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