Background:
Oxidative stress is one of the main contributing factors involved in cerebral biochemical
impairment. The higher susceptibility of the central nervous system to reactive oxygen species
mediated damage could be attributed to several factors. For example, neurons use a greater
quantity of oxygen, many parts of the brain have higher concentraton of iron, and neuronal
mitochondria produce huge content of hydrogen peroxide. In addition, neuronal membranes have
polyunsaturated fatty acids, which are predominantly vulnerable to oxidative stress (OS). OS is
the imbalance between reactive oxygen species generation and cellular antioxidant potential.
This may lead to various pathological conditions and diseases, especially neurodegenerative
diseases such as, Parkinson’s, Alzheimer’s, and Huntington’s diseases.
Objectives:
In this study, we explored the involvement of OS in neurodegenerative diseases.
Methods:
We used different search terms like “oxidative stress and neurological disorders” “free
radicals and neurodegenerative disorders” “oxidative stress, free radicals, and neurological
disorders” and “association of oxidative stress with the name of disorders taken from the list of
neurological disorders. We tried to summarize the source, biological effects, and physiologic
functions of ROS.
Results:
Finally, it was noted that more than 190 neurological disorders are associated with
oxidative stress.
894. Treating Neurological Disorders of MPS IIIB by AAV-CNS Gene Delivery Targeting Reactive Oxygen Species