Molecular Pathways Induced by Tumor–Microenvironment Interactions in Myeloma and the Regulatory Role of Heat-Shock Proteins

2009 ◽  
Vol 9 ◽  
pp. S13-S14
Author(s):  
Constantine S. Mitsiades ◽  
Douglas W. McMillin ◽  
Jake Delmore ◽  
Joseph Negri ◽  
Steffen Klippel ◽  
...  
Keyword(s):  
Heat Shock ◽  
Tumor Microenvironment ◽  
Heat Shock Proteins ◽  
Regulatory Role ◽  
Molecular Pathways ◽  
Shock Proteins

scholarly journals Heat Shock Proteins and Inflammasomes

2019 ◽  
Vol 20 (18) ◽  
pp. 4508 ◽  
Author(s):  
Pierre Martine ◽  
Cédric Rébé
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Inflammatory Cytokine ◽  
Molecular Pathways ◽  
Multiple Functions ◽  
Danger Signals ◽  
Caspase 1 ◽  
Shock Proteins ◽  
Inflammatory Caspases

Heat shock proteins (HSP) regulate inflammation in many physiological contexts. However, inflammation is a broad process, involving numerous cytokines produced by different molecular pathways with multiple functions. In this review, we focused on the particular role of HSP on the inflammasomes intracellular platforms activated by danger signals and that enable activation of inflammatory caspases, mainly caspase-1, leading to the production of the pro-inflammatory cytokine IL-1β. Interestingly, some members of the HSP family favor inflammasomes activation whereas others inhibit it, suggesting that HSP modulators for therapeutic purposes, must be carefully chosen.

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