463 Exercise-training of severe heart failure patients with complex co-morbidities: Is it feasible?

2005 ◽  
Vol 4 (1) ◽  
pp. 109-109
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Severe Heart Failure ◽  
Heart Failure Patients

scholarly journals 1108-124 Effect of exercise training on sleep disordered breathing in severe heart failure patients

2004 ◽  
Vol 43 (5) ◽  
pp. A200
Author(s):  
Dov Freimark ◽  
Peretz Lavie ◽  
Meirav Ingbir ◽  
Ehud Schwammenthal ◽  
Michael Motro ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Training ◽  
Sleep Disordered Breathing ◽  
Severe Heart Failure ◽  
Heart Failure Patients ◽  
Disordered Breathing

Cardiac mitofusin-1 is declined in non-responding patients with idiopathic dilated cardiomyopathy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y Hsiao ◽  
I Shimizu ◽  
T Wakasugi ◽  
S Jiao ◽  
T Watanabe ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Heart Failure ◽  
Ventricular Myocytes ◽  
Severe Heart Failure ◽  
Left Ventricular ◽  
Neonatal Rat ◽  
Heart Failure Patients ◽  
Underlying Mechanisms ◽  
Neonatal Rat Ventricular Myocytes ◽  
Mitofusin 1

Abstract Background/Introduction Mitochondria are dynamic regulators of cellular metabolism and homeostasis. The dysfunction of mitochondria has long been considered a major contributor to aging and age-related diseases. The prognosis of severe heart failure is still unacceptably poor and it is urgent to establish new therapies for this critical condition. Some patients with heart failure do not respond to established multidisciplinary treatment and they are classified as “non-responders”. The outcome is especially poor for non-responders, and underlying mechanisms are largely unknown. Purpose Studies indicate mitochondrial dysfunction has causal roles for metabolic remodeling in the failing heart, but underlying mechanisms remain to be explored. This study tried to elucidate the role of Mitofusin-1 in a failing heart. Methods We examined twenty-two heart failure patients who underwent endomyocardial biopsy of intraventricular septum. Patients were classified as non-responders when their left-ventricular (LV) ejection fraction did not show more than 10% improvement at remote phase after biopsy. Fourteen patients were classified as responders, and eight as non-responders. Electron microscopy, quantitative PCR, and immunofluorescence studies were performed to explore the biological processes or molecules involved in failure to respond. In addition to studies with cardiac tissue specific knockout mice, we also conducted functional in-vitro studies with neonatal rat ventricular myocytes. Results Twenty-two patients with IDCM who underwent endomyocardial biopsy were enrolled in this study, including 14 responders and 8 non-responders. Transmission electron microscopy (EM) showed a significant reduction in mitochondrial size in cardiomyocytes of non-responders compared to responders. Quantitative PCR revealed that transcript of mitochondrial fusion protein, Mitofusin-1, was significantly reduced in non-responders. Studies with neonatal rat ventricular myocytes (NRVMs) indicated that the beta-1 adrenergic receptor-mediated signaling pathway negatively regulates Mitofusin-1 expression. Suppression of Mitofusin-1 resulted in a significant reduction in mitochondrial respiration of NRVMs. We generated left ventricular pressure overload model with thoracic aortic constriction (TAC) in cardiac specific Mitofusin-1 knockout model (c-Mfn1 KO). Systolic function was reduced in c-Mfn1 KO mice, and EM study showed an increase in dysfunctional mitochondria in the KO group subjected to TAC. Conclusions Mitofusin-1 becomes a biomarker for non-responders with heart failure. In addition, our results suggest that therapies targeting mitochondrial dynamics and homeostasis would become next generation therapy for severe heart failure patients. Funding Acknowledgement Type of funding source: None

Levosimendan reduces plasma B-type natriuretic peptide and interleukin 6, and improves central hemodynamics in severe heart failure patients

2005 ◽  
Vol 99 (3) ◽  
pp. 409-413 ◽  
Author(s):  
Stamos Kyrzopoulos ◽  
Stamatis Adamopoulos ◽  
John T. Parissis ◽  
John Rassias ◽  
George Kostakis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Natriuretic Peptide ◽  
Interleukin 6 ◽  
Severe Heart Failure ◽  
Central Hemodynamics ◽  
Heart Failure Patients

scholarly journals Anemia in severe heart failure patients: does it predict prognosis?

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Tamrat Befekadu Abebe ◽  
Eyob Alemayehu Gebreyohannes ◽  
Akshaya Srikanth Bhagavathula ◽  
Yonas Getaye Tefera ◽  
Tadesse Melaku Abegaz
Keyword(s):  
Heart Failure ◽  
Severe Heart Failure ◽  
Heart Failure Patients

scholarly journals High Sensitivity C-Reactive Protein Predicts Nonresponders and Cardiac Deaths in Severe Heart Failure Patients After CRT Implantation

2012 ◽  
Vol 53 (5) ◽  
pp. 306-312 ◽  
Author(s):  
Masashi Kamioka ◽  
Hitoshi Suzuki ◽  
Shinya Yamada ◽  
Yoshiyuki Kamiyama ◽  
Shu-ichi Saitoh ◽  
...  
Keyword(s):  
Heart Failure ◽  
Severe Heart Failure ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Heart Failure Patients ◽  
Reactive Protein

Improvement in Exercise Capacity by Exercise Training is associated with Favorable Clinical Outcome in Advanced Chronic Heart Failure Patients

2014 ◽  
Vol 20 (10) ◽  
pp. S184
Author(s):  
Michio Nakanishi ◽  
Reon Kumasaka ◽  
Tetsuo Arakawa ◽  
Teruo Noguchi ◽  
Takahiro Ohara ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Exercise Training ◽  
Clinical Outcome ◽  
Exercise Capacity ◽  
Heart Failure Patients ◽  
Favorable Clinical Outcome
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