Abstract: P1297 THE LOW SERUM MAGNESIUM OF METABOLIC SYNDROME IS ASSOCIATED WITH INCREASED INTRACELLULAR MAGNESIUM RATHER THAN DEFICIENCY

Abstract Background/Aims: Individuals with metabolic syndrome are at higher risk to develop cardiovascular disease, diabetes type 2, and certain types of cancers such as pancreatic, liver, and colorectal cancers. Studies suggest a potential association between hypomagnesemia and metabolic syndrome with conflicting results. The present study aims to estimate the prevalence of metabolic syndrome and its components in Jordan and to further explore the association between low magnesium levels and metabolic syndrome and its components. Methods Data were derived from the national population-based household survey conducted in Jordan in 2009. The study was multipurpose and collected a wide array of data including interview data, anthropometric measurements, and laboratory data. The present report deals, exclusively, with subjects aged ≥ 20 years. There was a total of 4,520 subjects (1113 men and 3407 women). Results We found alarmingly high prevalence rates of metabolic syndrome and its components defined by IDF (international diabetic federation) criteria (39.8%) with the highest burden being among women (40.7% in women and 37.4% in men). Among metabolic syndrome components, central obesity and low HDL were the most commonly occurring components of metabolic syndrome (62.6% and 65.5%, respectively). We observed a significant inverse association between serum magnesium levels and metabolic syndrome after adjusting for age (OR = 1.57, p value = 0.048). Among metabolic syndrome components, low serum magnesium levels were significantly associated with low serum HDL levels (OR = 2.15, p value = 0.001). Conclusion Metabolic syndrome prevalence in Jordan is considerably high. Our findings suggest that serum magnesium levels are inversely associated with metabolic syndrome.

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Effect of Dapagliflozin and Magnesium Supplementation on Renal Magnesium Handling and Magnesium Homeostasis in Metabolic Syndrome

Nutrients ◽

10.3390/nu13114088 ◽

2021 ◽

Vol 13 (11) ◽

pp. 4088

Author(s):

Hwee-Yeong Ng ◽

Wei-Hung Kuo ◽

You-Lin Tain ◽

Foong-Fah Leung ◽

Wen-Chin Lee ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Magnesium Sulfate ◽

Serum Magnesium ◽

Sglt2 Inhibitors ◽

Magnesium Concentration ◽

Magnesium Supplementation ◽

Intracellular Magnesium ◽

Glucose Transporter 2 ◽

Magnesium Excretion

The prevalence of metabolic syndrome (MetS) is increasing, and patients with MetS are at an increased risk of cardiovascular disease and diabetes. There is a close link between hypomagnesemia and MetS. Administration of sodium-glucose transporter 2 (SGLT2) inhibitors has been reported to increase serum magnesium levels in patients with diabetes. We investigated the alterations in renal magnesium handling in an animal model of MetS and analyzed the effects of SGLT2 inhibitors. Adult rats were fed a fructose-rich diet to induce MetS in the first 3 months and were then treated with either dapagliflozin or magnesium sulfate-containing drinking water for another 3 months. Fructose-fed animals had increased insulin resistance, hypomagnesemia, and decreased urinary magnesium excretion. Dapagliflozin treatment improved insulin resistance by decreasing glucose and insulin levels, increased serum magnesium levels, and reduced urinary magnesium excretion. Serum vitamin D and parathyroid hormone levels were decreased in fructose-fed animals, and the levels remained low despite dapagliflozin and magnesium supplementation. In the kidney, claudin-16, TRPM6/7, and FXDY expression was increased in fructose-fed animals. Dapagliflozin increased intracellular magnesium concentration, and this effect was inhibited by TRPM6 blockade and the EGFR antagonist. We concluded that high fructose intake combined with a low-magnesium diet induced MetS and hypomagnesemia. Both dapagliflozin and magnesium sulfate supplementation improved the features of MetS and increased serum magnesium levels. Expression levels of magnesium transporters such as claudin-16, TRPM6/7, and FXYD2 were increased in fructose-fed animals and in those administered dapagliflozin and magnesium sulfate. Dapagliflozin enhances TRPM6-mediated trans-epithelial magnesium transport in renal tubule cells.

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Low serum magnesium levels and metabolic syndrome

Acta Diabetologica ◽

10.1007/s005920200036 ◽

2002 ◽

Vol 39 (4) ◽

pp. 209-213 ◽

Cited By ~ 140

Author(s):

F. Guerrero-Romero ◽

M. Rodríguez-Morán

Keyword(s):

Metabolic Syndrome ◽

Serum Magnesium ◽

Low Serum

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Faculty Opinions recommendation of Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.719010611.793501164 ◽

2014 ◽

Author(s):

Luis Ruilope ◽

Enrique Morales

Keyword(s):

Kidney Disease ◽

Serum Magnesium ◽

Atherosclerosis Risk In Communities ◽

Atherosclerosis Risk ◽

Low Serum

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Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study

Scientific Reports ◽

10.1038/s41598-018-28362-5 ◽

2018 ◽

Vol 8 (1) ◽

Author(s):

Kunling Wang ◽

Hongyan Wei ◽

Wanqi Zhang ◽

Zhen Li ◽

Li Ding ◽

...

Keyword(s):

Serum Magnesium ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Thyroglobulin Antibody ◽

Low Serum

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Low serum 25(OH)D levels are assocıated to hıgher BMI and metabolic syndrome parameters in adult subjects in Turkey

African Health Sciences ◽

10.4314/ahs.v15i4.15 ◽

2016 ◽

Vol 15 (4) ◽

pp. 1161 ◽

Cited By ~ 13

Author(s):

Guler Tosunbayraktar ◽

Murat Bas ◽

Altug Kut ◽

Aylin Hasby Buyukkaragoz

Keyword(s):

Metabolic Syndrome ◽

Low Serum

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Low serum zinc and magnesium–a possible risk factor for first episode Simple febrile seizures in children between 6 months to 5 years of age

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20213225 ◽

2021 ◽

Author(s):

Aishwarya Lakshmi L. G. ◽

Mohanraj Kannan ◽

Rajakumar P. G. ◽

Selvaraj R.

Keyword(s):

Febrile Seizure ◽

Serum Magnesium ◽

Serum Zinc ◽

Febrile Seizures ◽

Mean Value ◽

First Episode ◽

Control Group ◽

Case Group ◽

High Grade Fever ◽

Low Serum

Background: Febrile seizure is the most common type of seizure in children. The incidence of febrile seizure is 5-10% in India. There are multiple aetiologies like high grade fever; genetic predisposition, viral infections and trace elements deficiency like iron, zinc, magnesium and calcium are postulated to be risk factors for developing febrile seizures. Recent studies had shown there is a significant association between low serum zinc, low serum magnesium levels and febrile seizures in children.Methods: This was a case control study with 40 children in each group. Children aged 6 months to 5 years with first episode of simple febrile seizures who attends the out-patient department/emergency room (OPD/ER) were included in case group consecutively and 40 children with acute febrile illness without febrile seizures were included in control group. Serum zinc and magnesium levels were estimated for all the children along with other investigations after proper consent from parents. Using statistical package for the social sciences (SPSS) software, independent sample t test was used to analysis the observations between the two groups. Normal lab reference value of serum zinc was 60-120 μg/dl and serum magnesium was 1.7-2.5 mg/dl.Results: The incidence of febrile seizure was high (37.5%) in children between 1-2 years and male (55%) children had increased incidence when compared to female children in case group. The children with febrile seizure had significantly low levels of serum zinc with mean value of 35.08 μg/dl (±8.56) when compared to control group with mean value of 70.23 μg/dl (±13.41) and serum magnesium level in case group was 1.35 mg/dl (±0.29) versus 1.68 mg/dl (±0.42) in control group, which was also statistically significant.Conclusions: The incidence of febrile seizure was high in children between 1-2 years of age with male preponderance. The serum levels of both zinc and magnesium is significantly low in children with febrile seizure pointing a need of further studies in role of supplemental zinc and magnesium in this age group to reduce the incidence of febrile seizures.

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