Is Low Serum Magnesium Associated with Premature Labor?

Background: Febrile seizure is the most common type of seizure in children. The incidence of febrile seizure is 5-10% in India. There are multiple aetiologies like high grade fever; genetic predisposition, viral infections and trace elements deficiency like iron, zinc, magnesium and calcium are postulated to be risk factors for developing febrile seizures. Recent studies had shown there is a significant association between low serum zinc, low serum magnesium levels and febrile seizures in children.Methods: This was a case control study with 40 children in each group. Children aged 6 months to 5 years with first episode of simple febrile seizures who attends the out-patient department/emergency room (OPD/ER) were included in case group consecutively and 40 children with acute febrile illness without febrile seizures were included in control group. Serum zinc and magnesium levels were estimated for all the children along with other investigations after proper consent from parents. Using statistical package for the social sciences (SPSS) software, independent sample t test was used to analysis the observations between the two groups. Normal lab reference value of serum zinc was 60-120 μg/dl and serum magnesium was 1.7-2.5 mg/dl.Results: The incidence of febrile seizure was high (37.5%) in children between 1-2 years and male (55%) children had increased incidence when compared to female children in case group. The children with febrile seizure had significantly low levels of serum zinc with mean value of 35.08 μg/dl (±8.56) when compared to control group with mean value of 70.23 μg/dl (±13.41) and serum magnesium level in case group was 1.35 mg/dl (±0.29) versus 1.68 mg/dl (±0.42) in control group, which was also statistically significant.Conclusions: The incidence of febrile seizure was high in children between 1-2 years of age with male preponderance. The serum levels of both zinc and magnesium is significantly low in children with febrile seizure pointing a need of further studies in role of supplemental zinc and magnesium in this age group to reduce the incidence of febrile seizures.

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Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease

Kidney International ◽

10.1038/ki.2014.331 ◽

2015 ◽

Vol 87 (4) ◽

pp. 820-827 ◽

Cited By ~ 56

Author(s):

Adrienne Tin ◽

Morgan E. Grams ◽

Nisa M. Maruthur ◽

Brad C. Astor ◽

David Couper ◽

...

Keyword(s):

Kidney Disease ◽

Serum Magnesium ◽

Atherosclerosis Risk In Communities ◽

Atherosclerosis Risk ◽

Low Serum

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Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

Antioxidants ◽

10.3390/antiox9100907 ◽

2020 ◽

Vol 9 (10) ◽

pp. 907 ◽

Cited By ~ 1

Author(s):

Man Liu ◽

Samuel C. Dudley

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Heart Failure ◽

Cardiovascular Disease ◽

Clinical Trials ◽

Cardiovascular Diseases ◽

Serum Magnesium ◽

Mg Deficiency ◽

All Cause Mortality ◽

Low Serum

Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular and all-cause mortality and treating Mg deficiency may help prevent cardiovascular disease. In this review, we discuss the possible mechanisms by which Mg deficiency plays detrimental roles in cardiovascular diseases and review the results of clinical trials of Mg supplementation for heart failure, arrhythmias and other cardiovascular diseases.

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A prospective evaluation of thiamine and magnesium status in relation to clinicopathological characteristics and 1-year mortality in patients with alcohol withdrawal syndrome

Journal of Translational Medicine ◽

10.1186/s12967-019-02141-w ◽

2019 ◽

Vol 17 (1) ◽

Author(s):

Donogh Maguire ◽

Dinesh Talwar ◽

Alana Burns ◽

Anthony Catchpole ◽

Fiona Stefanowicz ◽

...

Keyword(s):

Alcohol Withdrawal ◽

Whole Blood ◽

Withdrawal Syndrome ◽

Serum Magnesium ◽

Elevated Serum ◽

Alcohol Withdrawal Syndrome ◽

Plasma Lactate ◽

Magnesium Status ◽

The Relationship ◽

Low Serum

Abstract Background Alcohol withdrawal syndrome (AWS) is routinely treated with B-vitamins. However, the relationship between thiamine status and outcome is rarely examined. The aim of the present study was to examine the relationship between thiamine and magnesium status in patients with AWS. Methods Patients (n = 127) presenting to the Emergency Department with AWS were recruited to a prospective observational study. Blood samples were drawn to measure whole blood thiamine diphosphate (TDP) and serum magnesium concentrations. Routine biochemistry and haematology assays were also conducted. The Glasgow Modified Alcohol Withdrawal Score (GMAWS) measured severity of AWS. Seizure history and current medications were also recorded. Results The majority of patients (99%) had whole blood TDP concentration within/above the reference interval (275–675 ng/gHb) and had been prescribed thiamine (70%). In contrast, the majority of patients (60%) had low serum magnesium concentrations (< 0.75 mmol/L) and had not been prescribed magnesium (93%). The majority of patients (66%) had plasma lactate concentrations above 2.0 mmol/L. At 1 year, 13 patients with AWS had died giving a mortality rate of 11%. Male gender (p < 0.05), BMI < 20 kg/m2 (p < 0.01), GMAWS max ≥ 4 (p < 0.05), elevated plasma lactate (p < 0.01), low albumin (p < 0.05) and elevated serum CRP (p < 0.05) were associated with greater 1-year mortality. Also, low serum magnesium at time of recruitment to study and low serum magnesium at next admission were associated with higher 1-year mortality rates, (84% and 100% respectively; both p < 0.05). Conclusion The prevalence of low circulating thiamine concentrations were rare and it was regularly prescribed in patients with AWS. In contrast, low serum magnesium concentrations were common and not prescribed. Low serum magnesium was associated more severe AWS and increased 1-year mortality.

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A Study on the Association between Low Maternal Serum Magnesium Level and Preterm Labour

Advances in Medicine ◽

10.1155/2014/704875 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Kehinde S. Okunade ◽

Ayodeji A. Oluwole ◽

Maymunah A. Adegbesan-Omilabu

Keyword(s):

Preterm Labour ◽

Serum Magnesium ◽

Tertiary Hospital ◽

Maternal Serum ◽

Magnesium Supplementation ◽

Cross Sectional ◽

The Mean ◽

Labour Ward ◽

Control Study ◽

Low Serum

Objectives.The study was aimed to assess the association between low maternal serum magnesium levels and preterm labour.Methods.It is a cross-sectional case-control study in which eligible participants were pregnant women admitted in labour within the labour ward complex of a Lagos tertiary hospital. Relevant data were extracted from the case records of these women and blood samples were obtained from all participants and serum magnesium levels measured.Results.The study showed that 36% of the study patients had varying degrees of hypomagnesaemia. The relative risk indicates that preterm labour is 1.83 times higher among the patients with low serum magnesium (less than 1.6 mg/dL). The mean difference in serum magnesium levels in both groups was statistically significant (P<0.05).Conclusion.We can infer that low serum magnesium (hypomagnesaemia) is associated with preterm onset of labour. We can, also from this finding, formulate a proposition that would help in preventing preterm labour and birth with the use of prophylactic oral magnesium supplementation among patients with higher risk for development of preterm labour.

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Abstract: P1297 THE LOW SERUM MAGNESIUM OF METABOLIC SYNDROME IS ASSOCIATED WITH INCREASED INTRACELLULAR MAGNESIUM RATHER THAN DEFICIENCY

Atherosclerosis Supplements ◽

10.1016/s1567-5688(09)71314-5 ◽

2009 ◽

Vol 10 (2) ◽

pp. e1353

Author(s):

V Gourineni ◽

G Nathanson ◽

M Wolfe ◽

S Volpe ◽

D Rader ◽

...

Keyword(s):

Metabolic Syndrome ◽

Serum Magnesium ◽

Intracellular Magnesium ◽

Low Serum

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Serum magnesium: a clinical biomarker for sudden unexpected death in epilepsy?

Journal of Epilepsy and Clinical Neurophysiology ◽

10.1590/s1676-26492011000200008 ◽

2011 ◽

Vol 17 (2) ◽

pp. 77-77 ◽

Cited By ~ 2

Author(s):

Vera C. Terra ◽

Marly de Albuquerque ◽

Carla A. Scorza ◽

Ricardo M. Arida ◽

Fulvio A. Scorza

Keyword(s):

Serum Magnesium ◽

Sudden Unexpected Death ◽

Healthy Population ◽

Unexpected Death ◽

The World ◽

Clinical Biomarker ◽

Effect Relation ◽

Possible Cause ◽

Low Serum ◽

Related Category

INTRODUCTION: Epilepsy is one of the most common chronic neurological disorder in the world and has a higher mortality rate than would be expected in a healthy population. One of the most related category of death is sudden unexpected death in epilepsy (SUDEP). Many risk factors have been related to SUDEP, but the mechanisms involved in its genesis is still unknown. OBJECTIVE: Here we describe one case of a patient with low serum magnesium levels that suffered of SUDEP. CONCLUSION: we discuss a possible cause-effect relation, suggesting that magnesium may be, in some cases, a biomarker of SUDEP.

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