scholarly journals WS04.2 Azithromycin treatment of Pseudomonas aeruginosa infection potentiates IgY pulmonary protection in vivo

2018 ◽  
Vol 17 ◽  
pp. S7-S8
Author(s):  
K. Thomsen ◽  
S. Larsen ◽  
L. Christophersen ◽  
C. Lerche ◽  
N. Høiby ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Infection ◽  
Pulmonary Protection

scholarly journals Acidosis Potentiates the Host Proinflammatory Interleukin-1β Response to Pseudomonas aeruginosa Infection

2014 ◽  
Vol 82 (11) ◽  
pp. 4689-4697 ◽  
Author(s):  
Iviana M. Torres ◽  
Yash R. Patankar ◽  
Tamer B. Shabaneh ◽  
Emily Dolben ◽  
Deborah A. Hogan ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Inflammatory Response ◽  
Inflammatory Responses ◽  
Interleukin 1Β ◽  
Acidic Environment ◽  
Content Type ◽  
Inflammatory Damage ◽  
Pseudomonas Aeruginosa Infection ◽  
Peritonitis Model

ABSTRACTInfection byPseudomonas aeruginosa, and bacteria in general, frequently promotes acidification of the local microenvironment, and this is reinforced by pulmonary exertion and exacerbation. However, the consequence of an acidic environment on the host inflammatory response toP. aeruginosainfection is poorly understood. Here we report that the pivotal cellular and host proinflammatory interleukin-1β (IL-1β) response, which enables host clearance of the infection but can produce collateral inflammatory damage, is increased in response toP. aeruginosainfection within an acidic environment. Synergistic mechanisms that promote increased IL-1β release in response toP. aeruginosainfection in an acidic environment are increased pro-IL-1β induction and increased caspase-1 activity, the latter being dependent upon a functional type III secretion system of the bacteria and the NLRC4 inflammasome of the host. Using anin vivoperitonitis model, we have validated that the IL-1β inflammatory response is increased in mice in response toP. aeruginosainfection within an acidic microenvironment. These data reveal novel insights into the regulation and exacerbation of inflammatory responses toP. aeruginosa.

Evidence for the in vivo degradation of human respiratory mucins during Pseudomonas aeruginosa infection

1989 ◽  
Vol 992 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Nicole Houdret ◽  
Reuben Ramphal ◽  
Andrèe Scharfman ◽  
Jean-Marc Perini ◽  
Monique Filliat ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Infection ◽  
In Vivo Degradation

In vivo impact of the MexAB-OprM efflux system on β-lactam efficacy in an experimental model of Pseudomonas aeruginosa infection

2009 ◽  
Vol 33 (5) ◽  
pp. 417-420 ◽  
Author(s):  
David Boutoille ◽  
Cédric Jacqueline ◽  
Virginie Le Mabecque ◽  
Gilles Potel ◽  
Jocelyne Caillon
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Experimental Model ◽  
Efflux System ◽  
Pseudomonas Aeruginosa Infection

scholarly journals Studies on Pseudomonas aeruginosa Infection in Hatcheries and Chicken

2020 ◽  
Vol 71 (1) ◽  
pp. 1953
Author(s):  
R. D. ERAKY ◽  
W. A. ABD EL-GHANY ◽  
K. M. SOLIMAN
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Abdominal Cavity ◽  
Broiler Chicks ◽  
Pathogenicity Test ◽  
Internal Organs ◽  
Highly Pathogenic ◽  
Pseudomonas Aeruginosa Infection ◽  
Polymerase Chain

The aim of this work was to spot light on the presence of Pseudomonas aeruginosa (P. aeruginosa) strains in hatcheries and dead in shell embryos. A total of 406 samples representing 200 and 206 swabs from hatcheries environment and yolk sacs of dead in shell embryos were collected from Damietta governorate, Egypt. P. aeruginosa was isolated and identified. Some virulent genes (toxA, psIA and fliC) of P. aeruginosa were detected using polymerase chain reaction (PCR). The antimicrobial susceptibility of P. aeruginosa was tested in vitro. Day and 11 days old broiler chicks were challenged with P. aeruginosa to determine the pathogenicity of the isolated strains. The results showed that P. aeruginosa was recovered from 16 (8%) out of 200 hatcheries and from 17 (8.25%) out of 206 chicken embryos samples. Isolated strains of P. aeruginosa showed presence of toxA, psIA and fliC virulent genes. P. aeruginosa strains were sensitive (100%) to ciprofloxacin, levofloxacin and gentamycin but resistant (100%) to amoxycillin/clavulanic acid, doxycycline and erythromycin. The pathogenicity test of day and 11 days old chicks revealed that P. aeruginosa was highly pathogenic induced mortality rates of 72 and 40%, respectively. Septicaemia of internal organs, unabsorbed yolk sacs, pneumonia, greenish exudates in the abdominal cavity, liver necrosis and enteritis were the predominant lesions. Histopathological changes supported the previous lesions. In conclusion, P. aeruginosa is of great importance pathogen of embryos and newly hatched chicks based on presence of virulent genes as well as in vivo pathogenicity study; respectively.

scholarly journals Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99029 ◽  
Author(s):  
Paula E. Beaumont ◽  
Brian McHugh ◽  
Emily Gwyer Findlay ◽  
Annie Mackellar ◽  
Karen J. Mackenzie ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Neutrophil Function ◽  
Host Defence ◽  
Pseudomonas Aeruginosa Infection
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