Chapter 6.1 The role of microdialysis in drug discovery: focus on antipsychotic agents

2006 ◽  
pp. 485-511 ◽  
Author(s):  
M.J. Millan ◽  
F. Panayi ◽  
J.M. Rivet ◽  
B. Di Cara ◽  
L. Cistarelli ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Antipsychotic Agents

scholarly journals Emerging Role of Electron Microscopy in Drug Discovery

2019 ◽  
Vol 44 (10) ◽  
pp. 897-898 ◽  
Author(s):  
Rachel M. Johnson ◽  
Anna J. Higgins ◽  
Stephen P. Muench
Keyword(s):  
Electron Microscopy ◽  
Drug Discovery

Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data

2020 ◽  
Vol 107 (4) ◽  
pp. 796-805 ◽  
Author(s):  
Daniela J. Conrado ◽  
Sridhar Duvvuri ◽  
Hugo Geerts ◽  
Jackson Burton ◽  
Carla Biesdorf ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Open Data ◽  
Drug Discovery And Development ◽  
Modeling Simulation

From Lock-In to Transformation: A Path-Centric Theory of Emerging Technology an Organizing

2021 ◽  
Author(s):  
Brian T. Pentland ◽  
Youngjin Yoo ◽  
Jan Recker ◽  
Inkyu Kim
Keyword(s):  
Drug Discovery ◽  
Dynamic Simulation ◽  
Emerging Technologies ◽  
Emerging Technology ◽  
Basic Question ◽  
Transformative Change ◽  
Pharmaceutical Drug ◽  
Wide Range ◽  
Lock In

We offer a path-centric theory of emerging technology and organizing that addresses a basic question. When does emerging technology lead to transformative change? A path-centric perspective on technology focuses on the patterns of actions afforded by technology in use. We identify performing and patterning as self-reinforcing mechanisms that shape patterns of action in the domain of emerging technology and organizing. We use a dynamic simulation to show that performing and patterning can lead to a wide range of trajectories, from lock-in to transformation, depending on how emerging technology in use influences the pattern of action. When emerging technologies afford new actions that can be flexibly recombined to generate new paths, decisive transformative effects are more likely. By themselves, new affordances are not likely to generate transformation. We illustrate this theory with examples from the practice of pharmaceutical drug discovery. The path-centric perspective offers a new way to think about generativity and the role of affordances in organizing.

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