Updating of the ERSPC Rotterdam Prostate Cancer Risk Calculator for initial prostate biopsy to contemporary practice including the 2014 ISUP Gleason grading and cribriform growth patterns

2016 ◽  
Vol 15 (13) ◽  
pp. e1622-e1624
Author(s):  
M. Roobol ◽  
J. Verbeek ◽  
C. Kweldam ◽  
A. Van Leenders
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Biopsy ◽  
Prostate Cancer Risk ◽  
Growth Patterns ◽  
Risk Calculator ◽  
Gleason Grading ◽  
Contemporary Practice

scholarly journals Next-generation prostate cancer risk calculator for primary care physicians

2017 ◽  
Vol 12 (2) ◽  
pp. E64-70 ◽  
Author(s):  
Robert K. Nam ◽  
Raj Satkunasivam ◽  
Joseph L. Chin ◽  
Jonathan Izawa ◽  
John Trachtenberg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Life Expectancy ◽  
Prostate Biopsy ◽  
Primary Care Physicians ◽  
Prostate Cancer Risk ◽  
Concordance Index ◽  
Risk Calculator ◽  
Next Generation ◽  
Term Survival

Introduction: Current prostate cancer risk calculators are limited in impact because only a probability of having prostate cancer is provided. We developed the next generation of prostate cancer risk calculator that incorporates life expectancy in order to better evaluate prostate cancer risk in context to a patient’s age and comorbidity.Methods: We combined two cohorts to develop the new risk calculator. The first was 5638 subjects who all underwent a prostate biopsy for prostate cancer detection. The second was 979 men diagnosed with prostate cancer with long-term survival data. Two regression models were used to create multivariable nomograms and an online prostate cancer risk calculator was developed.Results: Of the 5638 patients who underwent a prostate biopsy, 629 (11%) were diagnosed with aggressive prostate cancer (Gleason Score 7[4+3] or more). Of the 979 patients who underwent treatment for prostate cancer, the 10-year overall survival (OS) was 49.6% (95% confidence interval [CI] 46.6‒52.9). The first multivariable nomogram for cancer risk had a concordance index of 0.74 (95% CI 0.72, 0.76), and the second nomogram to predict survival had a concordance index of 0.71 (95% CI 0.69‒0.72). The nextgeneration prostate cancer risk calculator was developed online and is available at: http://riskcalc.org/ProstateCA_Screen_Tool.Conclusions: We have developed the next-generation prostate cancer risk calculator that incorporates a patient’s life expectancy based on age and comorbidity. This approach will better evaluate prostate cancer risk. Future studies examining other populations will be needed for validation.

PROSTATE BIOPSY OUTCOME PREDICTION – COMPARISON OF A NOVEL LOGISTIC REGRESSION-BASED MODEL, THE PROSTATE CANCER RISK CALCULATOR AND PSA ALONE

2008 ◽  
Vol 179 (4S) ◽  
pp. 640-641
Author(s):  
David J Hernandez ◽  
Misop Han ◽  
Elizabeth B Humphreys ◽  
Leslie A Mangold ◽  
Michael K Brawer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Logistic Regression ◽  
Cancer Risk ◽  
Prostate Biopsy ◽  
Outcome Prediction ◽  
Prostate Cancer Risk ◽  
Risk Calculator

scholarly journals PD38-04 IMPACT OF USING THE PROSTATE BIOPSY COLLABORATE GROUP RISK CALCULATOR TO INFORM UROLOGY REFERRAL FOR PROSTATE CANCER RISK

2020 ◽  
Vol 203 ◽  
pp. e802
Author(s):  
James Kearns* ◽  
William Anderson ◽  
Timothy Hetherington ◽  
Earle Burgess ◽  
Stephen Riggs ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Biopsy ◽  
Prostate Cancer Risk ◽  
Risk Calculator
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