Imaging human skeletal muscle regeneration after stem cell application for sphincter reconstruction using diffusion tensor imaging (DTI) and magnetisation transfer (MT) measurements

2017 ◽  
Vol 16 (3) ◽  
pp. e531
Author(s):  
D. Keller ◽  
C. Eberhardt ◽  
M. Rottmar ◽  
D. Haralampieva ◽  
T. Sulser ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Diffusion Tensor Imaging ◽  
Muscle Regeneration ◽  
Human Skeletal Muscle ◽  
Diffusion Tensor ◽  
Skeletal Muscle Regeneration ◽  
Magnetisation Transfer ◽  
Sphincter Reconstruction ◽  
Diffusion Tensor Imaging Dti

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

FEBS Letters ◽  
2015 ◽  
Vol 589 (11) ◽  
pp. 1257-1265 ◽  
Author(s):  
Yoshihiro Nakamura ◽  
Shigeru Miyaki ◽  
Hiroyuki Ishitobi ◽  
Sho Matsuyama ◽  
Tomoyuki Nakasa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration

Diffusion tensor imaging in evaluation of human skeletal muscle injury

2006 ◽  
Vol 24 (2) ◽  
pp. 402-408 ◽  
Author(s):  
Tatiana Zaraiskaya ◽  
Dinesh Kumbhare ◽  
Michael D. Noseworthy
Keyword(s):  
Skeletal Muscle ◽  
Diffusion Tensor Imaging ◽  
Muscle Injury ◽  
Human Skeletal Muscle ◽  
Diffusion Tensor ◽  
Skeletal Muscle Injury

scholarly journals Tumor Necrosis Factor-α Inhibition of Skeletal Muscle Regeneration Is Mediated by a Caspase-Dependent Stem Cell Response

Stem Cells ◽  
2008 ◽  
Vol 26 (4) ◽  
pp. 997-1008 ◽  
Author(s):  
Viviana Moresi ◽  
Alessandro Pristerà ◽  
Bianca M. Scicchitano ◽  
Mario Molinaro ◽  
Laura Teodori ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Tumor Necrosis Factor ◽  
Muscle Regeneration ◽  
Cell Response ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Skeletal Muscle Regeneration ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals R-spondin1 regulates muscle progenitor cell fusion through control of antagonist Wnt signaling pathways

2016 ◽  
Author(s):  
Floriane Lacour ◽  
Elsa Vezin ◽  
Florian Bentzinger ◽  
Marie-Claude Sincennes ◽  
Robert D. Mitchell ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Wnt Signaling ◽  
Signaling Pathways ◽  
Muscle Regeneration ◽  
Muscle Cells ◽  
Skeletal Muscle Regeneration ◽  
Acute Injury ◽  
Canonical Wnt

SUMMARYTissue regeneration requires the selective activation and repression of specific signaling pathways in stem cells. As such, the Wnt signaling pathways have been shown to control stem cell fate. In many cell types, the R-Spondin (Rspo) family of secreted proteins acts as potent activators of the canonical Wnt/β-catenin pathway. Here, we identify Rspo1 as a mediator of skeletal muscle tissue repair. Firstly we show that Rspo1-null muscles do not display any abnormalities at the basal level. However deletion of Rspo1 results in global alteration of muscle regeneration kinetics following acute injury. We found that muscle stem cells lacking Rspo1 show delayed differentiation. Transcriptome analysis further demonstrated that Rspo1 is required for the activation of Wnt/β-catenin target genes in muscle cells. Furthermore, muscle cells lacking Rspo1 fuse with a higher frequency than normal cells, leading to larger myotubes containing more nuclei both in vitro and in vivo. We found the increase in muscle fusion was dependent on up-regulation of non-canonical Wnt7a/Fzd7/Rac1 signaling. We conclude that antagonistic control of canonical and non-canonical Wnt signaling pathways by Rspo1 in muscle stem cell progeny is important for restitution of normal muscle architecture during skeletal muscle regeneration.

scholarly journals CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration

2021 ◽  
Vol 16 (9) ◽  
pp. 2089-2098
Author(s):  
Krishnamoorthy Sreenivasan ◽  
Alejandra Rodríguez-delaRosa ◽  
Johnny Kim ◽  
Diana Mesquita ◽  
Jessica Segalés ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Muscle Regeneration ◽  
Cell Lineage ◽  
Skeletal Muscle Regeneration ◽  
Stem Cell Lineage

scholarly journals Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration

Cell Reports ◽  
2020 ◽  
Vol 30 (10) ◽  
pp. 3583-3595.e5 ◽  
Author(s):  
Andrea J. De Micheli ◽  
Emily J. Laurilliard ◽  
Charles L. Heinke ◽  
Hiranmayi Ravichandran ◽  
Paula Fraczek ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Single Cell ◽  
Muscle Regeneration ◽  
Single Cell Analysis ◽  
Skeletal Muscle Regeneration ◽  
Cell Analysis ◽  
Muscle Stem Cell ◽  
Communication Signals ◽  
Stem Cell Hierarchy

The effects of organophosphates in the early stages of human skeletal muscle regeneration

2020 ◽  
pp. 829-841
Author(s):  
Tomaz Mars ◽  
Katarina Mis ◽  
Maja Katalinic ◽  
Katarina Pegan ◽  
Zoran Grubic ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Regeneration ◽  
Early Stages
Sign in / Sign up

Export Citation Format

Share Document