Systemic perfluorohexane attenuates lung injury induced by lipopolysaccharide in rats: the role of heme oxygenase-1

2010 ◽  
Vol 62 (1) ◽  
pp. 170-177 ◽  
Author(s):  
Zhi-Jun Ge ◽  
Guo-Jun Jiang ◽  
Yan-Ping Zhao ◽  
Guo-Xiang Wang ◽  
Yong-Fei Tan
Keyword(s):  
Lung Injury ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

scholarly journals Regulatory role of heme oxygenase-1 in silica-induced lung injury

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Kentaro Nakashima ◽  
Takashi Sato ◽  
Suguru Shigemori ◽  
Takeshi Shimosato ◽  
Masaharu Shinkai ◽  
...  
Keyword(s):  
Lung Injury ◽  
Heme Oxygenase ◽  
Regulatory Role ◽  
Heme Oxygenase 1

Involvement of Heme Oxygenase-1 in Neuropsychiatric and Neurodegenerative Diseases

2018 ◽  
Vol 24 (20) ◽  
pp. 2283-2302 ◽  
Author(s):  
Vivian B. Neis ◽  
Priscila B. Rosa ◽  
Morgana Moretti ◽  
Ana Lucia S. Rodrigues
Keyword(s):  
Neurodegenerative Diseases ◽  
Heme Oxygenase ◽  
Therapeutic Potential ◽  
Redox Homeostasis ◽  
Antioxidant Defenses ◽  
Heme Oxygenase 1 ◽  
Physiological Conditions ◽  
And Oxidative Stress ◽  
Defensive Mechanism

Heme oxygenase (HO) family catalyzes the conversion of heme into free iron, carbon monoxide and biliverdin. It possesses two well-characterized isoforms: HO-1 and HO-2. Under brain physiological conditions, the expression of HO-2 is constitutive, abundant and ubiquitous, whereas HO-1 mRNA and protein are restricted to small populations of neurons and neuroglia. HO-1 is an inducible enzyme that has been shown to participate as an essential defensive mechanism for neurons exposed to oxidant challenges, being related to antioxidant defenses in certain neuropathological conditions. Considering that neurodegenerative diseases (Alzheimer’s Disease (AD), Parkinson’s Disease (PD) and Multiple Sclerosis (MS)) and neuropsychiatric disorders (depression, anxiety, Bipolar Disorder (BD) and schizophrenia) are associated with increased inflammatory markers, impaired redox homeostasis and oxidative stress, conditions that may be associated with alterations in HO-levels/activity, the purpose of this review is to present evidence on the possible role of HO-1 in these Central Nervous System (CNS) diseases. In addition, the possible therapeutic potential of targeting brain HO-1 is explored in this review.

The Role of Statins in the Activation of Heme Oxygenase-1 in Cardiovascular Diseases

2017 ◽  
Vol 18 (6) ◽  
pp. 674-686 ◽  
Author(s):  
Aleksandra Piechota-Polanczyk ◽  
Alicja Jozkowicz
Keyword(s):  
Cardiovascular Diseases ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

scholarly journals Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis

2004 ◽  
Vol 85 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Isabel Devesa ◽  
Maria Luisa Ferrándiz ◽  
Isabel Guillén ◽  
José Miguel Cerdá ◽  
Maria José Alcaraz
Keyword(s):  
Heme Oxygenase ◽  
Adjuvant Arthritis ◽  
Potential Role ◽  
Heme Oxygenase 1 ◽  
Rat Adjuvant Arthritis
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