LB016 EFFECTS OF EARLY ORAL FEEDING ON SURGICAL OUTCOMES AND RECOVERY AFTER CURATIVE SURGERY FOR GASTRIC CANCER PATIENTS: PILOT STUDY RESULTS

Background: The early oral feeding after the laparoscopic total gastrectomy contributes to the enhanced treatment efficiency and improved quality of life of gastric cancer patients. To evaluate the efficiency of early oral feeding after laparoscopic total gastrectomy in gastric cancer patients at the Nghe An General Friendship Hospital. Methods: A retrospective observational study, performed in patients who underwent laparoscopic total gastrectomy from 2014 to 2020. Results: 126 patients were recruited. The mean age was 60.6 ± 11.1 years. The male/female ratio was 2.8/1. 15.9% of patients had the tumor at the one-third upper stomach, 81.7% at the middle of the stomach. 70.6% of patients contracted adenocarcinoma and ductal carcinoma, 24.6% of patients had ring cell carcinoma. The percent of tumor at stages I, II, III were respectively 19.0%, 49.2%, 31.7%. There were 71.4% of cases underwent laparoscopic total gastrectomy and were made the anastomosis by linear staplers. No case presented complications relating to the anastomosis after the surgery. The mean oral feeding time was 4.4 ± 1.9 (2 – 8 days), 27.8% of cases started at the second postoperative date, 8.7% of cases at the third postoperative date, 29.4% of cases from the fourth and fifth date, and 34.1% of cases started from the sixth date and further. The later the oral feeding time was, the slower recovery of the peristalsis was and vice versa (p < 0.05). There was no difference between the feeding time and the complications (p > 0.05). The more early the feeding time was, the shorter duration of antibiotic therapy observed and vice versa (p < 0.05). The more early the feeding time was, the short duration of hospital stay was and vice versa (p < 0.05). Conclusions: The early oral feeding after laparoscopic total gastrectomy was safe and contributed to improving the efficiency of the treatment, the quality of life in gastric cancer patients. Keywords: Early oral feeding, gastric cancer.

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CLINICAL SIGNIFICANCE OF SERUM CAVEOLIN-1 LEVELS IN GASTRIC CANCER PATIENTS

Experimental Oncology ◽

10.31768/2312-8852.2018.40(4):323-327 ◽

2018 ◽

Vol 40 (4) ◽

pp. 323-327 ◽

Cited By ~ 2

Author(s):

F Tas ◽

S Karabulut ◽

K Erturk ◽

D Duranyildiz

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Histological Grade ◽

Clinical Importance ◽

Disease Stage ◽

Control Group ◽

Tissue Samples ◽

Caveolin 1 ◽

Study Results ◽

Gastric Cancer Patients

Aim: Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examined serum caveolin-1 levels in gastric cancer patients so far, instead all available results were provided from studies conducted on tissue samples. In the current study, we analyzed the soluble serum caveolin-1 levels in gastric cancer patients, and specified its associations with the clinical factors and prognosis. Material and Methods: Sixty-three patients with pathologically confirmed gastric cancer were enrolled into the trial. Serum caveolin-1 concentrations were detected by ELISA method. Thirty healthy subjects were also included in the study. Results: The median age of patients was 62 years, ranging from 28 to 82 years. The serum caveolin-1 levels in gastric cancer patients were significantly higher than those in control group (p < 0.001). The common clinical parameters including patient age, sex, lesion localization, histopathology, histological grade, disease stage, and various serum tumor markers (e.g. LDH, CEA, and CA 19.9) were not found to be associated with serum caveolin-1 levels (p > 0.05). Similarly, no correlation existed between serum caveolin-1 concentration and chemotherapy responsiveness (p = 0.93). Furthermore, serum caveolin-1 level was not found to have a prognostic role (p = 0.16). Conclusion: Even though it is neither predictive nor prognostic, serum caveolin-1 level may be a valuable diagnostic indicator in patients with gastric cancer. Key

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