PP071-MON PRE-OPERATIVE WEIGHT LOSS INFLUENCES RECOVERY FOLLOWING POTENTIALLY CURATIVE RESECTION IN PATIENTS WITH UPPER GASTROINTESTINAL CANCER

2011 ◽  
Vol 6 (1) ◽  
pp. 142
Author(s):  
N.A. Stephens ◽  
A.J. MacDonald ◽  
R.J. Skipworth ◽  
C.A. Greig ◽  
K.C. Fearon
2021 ◽  
Vol 148 (12) ◽  
pp. 158-164
Author(s):  
Tran Hieu Hoc ◽  
Nguyen Duy Hieu ◽  
Pham Van Phu ◽  
Tran Thu Huong ◽  
Tran Que Son

Malnutrition is closely related to the outcome of disease treatment, especially in digestive cancer surgery. The aim of this study was to assess the nutritional condition of pre-operative patients with upper digestive cancers (including stomach and oesophagus) at the Department of General Surgery, Bach Mai Hospital in 2016. We conducted a cross-sectional descriptive analysis of 76 malignancies of the upper gastrointestinal tract with surgical treatments. The results revealed that the weight loss rate of hospitalized patients with gastric cancer and esophageal cancer was 76.6% and 66.7%, respectively. The rate of weight loss above 10% of body weight was 19.7%. The prevalence of chronic energy deficit was 29.9%. The risk of malnutrition according to SGA was 77.6%, of which mild to moderate and severe was 67.2% and 10.4%, respectively. The rate of low blood albumin level (less than 35 g/L) was 36.5%. The average net nutritional value was 1146.3 ± 592.7 Kcal (range 246.7 – 3653.5), which equals to 55.7% of the necessary daily intake. Protein, lipid, and glucid contents reached 73.4%, 57.8%, and 52.1% of the recommended levels, respectively. Conclusion: malnutrition was still prevalent among patients undergoing upper gastrointestinal cancer surgery, and pre-operative nutritional status does not achieve recommended levels.


Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1594 ◽  
Author(s):  
Janice Miller ◽  
Ahmed Alshehri ◽  
Michael I. Ramage ◽  
Nathan A. Stephens ◽  
Alexander B. Mullen ◽  
...  

Cachexia is a multifactorial wasting syndrome associated with high morbidity and mortality in patients with cancer. Diagnosis can be difficult and, in the clinical situation, usually relies upon reported weight loss. The ‘omics’ technologies allow us the opportunity to study the end points of many biological processes. Among these, blood-based metabolomics is a promising method to investigate the pathophysiology of human cancer cachexia and identify candidate biomarkers. In this study, we performed liquid chromatography mass spectrometry (LC/MS)-based metabolomics to investigate the metabolic profile of cancer-associated weight loss. Non-selected patients undergoing surgery with curative intent for upper gastrointestinal cancer were recruited. Fasting plasma samples were taken at induction of anaesthesia. LC/MS analysis showed that 6 metabolites were highly discriminative of weight loss. Specifically, a combination profile of LysoPC 18.2, L-Proline, Hexadecanoic acid, Octadecanoic acid, Phenylalanine and LysoPC 16:1 showed close correlation for eight weight-losing samples (≥5% weight loss) and nine weight-stable samples (<5%weight loss) between predicted and actual weight change (r = 0.976, p = 0.0014). Overall, 40 metabolites were associated with ≥5% weight loss. This study provides biological validation of the consensus definition of cancer cachexia (Fearon et al.) and provides feasible candidate markers for further investigation in early diagnosis and the assessment of therapeutic intervention.


2021 ◽  
Vol 267 ◽  
pp. 516-526
Author(s):  
Lukas F. Liesenfeld ◽  
Thomas Schmidt ◽  
Christine Zhang-Hagenlocher ◽  
Peter Sauer ◽  
Markus K. Diener ◽  
...  

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