P196 Epstein-Barr virus and transforming growth Factor Beta1 in head and neck cancer during concurrent chemo-radiotherapy

2007 ◽  
Vol 2 (1) ◽  
pp. 190
Author(s):  
H.W. Chen ◽  
S.F. Yang ◽  
Y.C. Chang ◽  
J.J. Hwang
Keyword(s):  
Head And Neck Cancer ◽  
Growth Factor ◽  
Head And Neck ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Beta1 ◽  
Barr Virus ◽  
Epstein Barr

Head and neck cancer in patients with human immunodeficiency virus-1 infection: incidence, outcome and association with Epstein-Barr virus

2004 ◽  
Vol 118 (3) ◽  
pp. 207-212 ◽  
Author(s):  
T. Powles ◽  
J. Powles ◽  
M. Nelson ◽  
A. Sandison ◽  
D. Peston ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Clinical Features ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Human Immunodeficiency Virus 1

Head and neck cancers have been described in patients with human immunodeficiency virus-1 (HIV-1) infection. However the incidence, aetiology and clinical features of the disease remain unclear.Patients with head and neck cancer and HIV were identified from a large HIV centre. The incidence and clinical features were recorded, and the tumours were stained for Epstein-Barr virus (EBV).Head and neckcancer occurred more frequently than in an age-matched control group (1.66 vs 0.55/10,000 patient years respectively p < 0.05). Highly active anti-retroviral therapy has not significantly altered the incidence of the disease. All of the tumours tested were positive for EBV. Patients were moderately immunosuppressed at diagnosis and had aggressive tumours. All but one of the patients died of cancer with a median survival of 28 months.Head and neck cancer occurs more frequently in HIV. It is an aggressive disease and EBV may play a role in its pathogenesis.

Epstein-barr virus (EBV) antibody in patients treated by radical radiotherapy for head and neck cancer

1978 ◽  
Vol 10 (5) ◽  
pp. 457-463 ◽  
Author(s):  
Marlene R. Halili ◽  
Ilya Spigland ◽  
Nan Foster ◽  
Nemetallah A. Ghossein
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Radical Radiotherapy ◽  
Barr Virus ◽  
Epstein Barr

Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers

2008 ◽  
Vol 128 (10) ◽  
pp. 1145-1151 ◽  
Author(s):  
Hong-Wen Chen ◽  
Sheau-Fang Yang ◽  
Yue-Cune Chang ◽  
Tao-Yeung Wang ◽  
Yu-Jen Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Virus Infection ◽  
Head And Neck ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein-Barr Virus in Head and Neck Cancer Assessed by Quantitative Polymerase Chain Reaction

2004 ◽  
Vol 114 (6) ◽  
pp. 1027-1031 ◽  
Author(s):  
David Goldenberg ◽  
Nicole E. Benoit ◽  
Shahnaz Begum ◽  
William H. Westra ◽  
Yoram Cohen ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Quantitative Polymerase Chain Reaction ◽  
Chain Reaction ◽  
Barr Virus ◽  
Polymerase Chain ◽  
Epstein Barr

scholarly journals Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM

2000 ◽  
Vol 74 (5) ◽  
pp. 2443-2446 ◽  
Author(s):  
Jingwu Xu ◽  
Ali Ahmad ◽  
James F. Jones ◽  
Riccardo Dolcetti ◽  
Emanuela Vaccher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epstein Barr Virus ◽  
Transforming Growth Factor ◽  
Immunoglobulin A ◽  
Elevated Serum ◽  
Transforming Growth Factor Β ◽  
Serum Levels ◽  
Barr Virus ◽  
Associated Diseases ◽  
Epstein Barr

ABSTRACT Transforming growth factor β (TGF-β) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-β in various EBV-associated diseases correlating positively with EBV-specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

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