273 SPINAL CORD STIMULATION DOES NOT WORK IN SMALL-FIBRE NEUROPATHY OF THE LOWER LIMBS

2010 ◽  
Vol 4 (S1) ◽  
pp. 79-79
Author(s):  
C. Bonezzi ◽  
M. Buonocore ◽  
A. Gatti ◽  
L. Demartini ◽  
A.M. Aloisi
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Lower Limbs ◽  
Small Fibre Neuropathy ◽  
Small Fibre

scholarly journals High-frequency spinal cord stimulation for treating pain in the lower limbs accompanied by bilateral para-anesthesia: A case report

2020 ◽  
Vol 8 (3) ◽  
pp. 132-137
Author(s):  
Zhuqiang Cheng
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
High Frequency ◽  
Severe Pain ◽  
Traffic Accident ◽  
Lower Limbs ◽  
Sensory Impairment ◽  
Remarkable Effect ◽  
Muscle Twitching

A 46-year-old female patient experienced severe pain in both lower limbs following a traffic accident in 2008. The pain mainly presented in her feet; she also experienced sensory impairment, convulsions, and exercise function disorders. She was diagnosed with neuropathic pain, and no medicine had any remarkable effect. Therefore, spinal cord stimulation (SCS) was performed in October 2019. Her pain did not reduce after the initial adoption of conventional SCS until the application of high frequency SCS (HF-SCS). At the 6-month follow-up, the pain in her lower limbs was considerably reduced, lower limb motor function was slightly improved, and muscle twitching in both feet disappeared.

scholarly journals Spinal Cord Stimulation as a Treatment Option for Refractory Chemotherapy-Induced Peripheral Neuropathy: Case Report

2020 ◽  
Vol 39 (03) ◽  
pp. 228-231 ◽  
Author(s):  
Arthur Lopes ◽  
Kleber Duarte ◽  
Catarina Lins ◽  
Gabriel Kubota ◽  
Valquíria Silva ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Spinal Cord ◽  
Neuropathic Pain ◽  
Case Report ◽  
Peripheral Neuropathy ◽  
Treatment Option ◽  
Spinal Cord Stimulation ◽  
Lower Limbs ◽  
Oncological Diseases ◽  
Good Treatment Option

AbstractColorectal cancer is one of the most common oncological diseases. Chemotherapy is usually recommended as an adjuvant treatment for stage-II, -III, and -IV tumors. Approximately 10% of the patients develop neuropathic pain after chemotherapy, and they may remain refractory despite the administration of drugs that are commonly used to treat neuropathic pain. Spinal cord stimulation is a good treatment option for neuropathic pain of the lower limbs, and it should be trialed in patients with chemotherapy-induced peripheral neuropathy. We report the case of a patient with oxaliplatin-induced neuropathy and neuropathic pain refractory to oral medication who was successfully treated by spinal cord stimulation.

scholarly journals Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies

2019 ◽  
Vol 91 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Yannick Tholance ◽  
Christian Peter Moritz ◽  
Carole Rosier ◽  
Karine Ferraud ◽  
François Lassablière ◽  
...  
Keyword(s):  
Dorsal Root ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Sensory Neuropathy ◽  
Lower Limbs ◽  
Clinical Pattern ◽  
Small Fibre Neuropathy ◽  
Small Fibre ◽  
Immunological Mechanisms ◽  
Pure Sn

ObjectiveSensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN affecting mostly the dorsal root ganglion (DRG). The aim of this study was to identify the frequency of anti-FGFR3 antibodies and the associated clinical pattern in a large cohort of patients with SN.MethodsA prospective, multicentric, European and Brazilian study included adults with pure SN. Serum anti-FGRF3 antibodies were analysed by ELISA. Detailed clinical and paraclinical data were collected for each anti-FGFR3-positive patient and as control for anti-FGFR3-negative patients from the same centres (‘center-matched’).ResultsSixty-five patients out of 426 (15%) had anti-FGFR3 antibodies, which were the only identified autoimmune markers in 43 patients (66%). The neuropathy was non-length dependent in 89% and classified as sensory neuronopathy in 64%, non-length-dependent small fibre neuropathy in 17% and other neuropathy in 19%. Specific clinical features occurred after 5–6 years of evolution including frequent paresthesia, predominant clinical and electrophysiological involvement of the lower limbs, and a less frequent mixed large and small fibre involvement. Brazilians had a higher frequency of anti-FGFR3 antibodies than Europeans (36% vs 13%, p<0.001), and a more frequent asymmetrical distribution of symptoms (OR 169, 95% CI 3.4 to 8424).ConclusionsAnti-FGFR3 antibodies occur in a subgroup of SN probably predominantly affecting the DRG. Differences between Europeans and Brazilians could suggest involvement of genetic or environmental factors.

scholarly journals Influence of Spine Curvature on the Efficacy of Transcutaneous Lumbar Spinal Cord Stimulation

2021 ◽  
Vol 10 (23) ◽  
pp. 5543
Author(s):  
Veronika E. Binder ◽  
Ursula S. Hofstoetter ◽  
Anna Rienmüller ◽  
Zoltán Száva ◽  
Matthias J. Krenn ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Thoracolumbar Spine ◽  
Lower Limbs ◽  
Lumbar Spinal Cord ◽  
Specific Effects ◽  
Afferent Fibers ◽  
Lumbar Spinal ◽  
Transcutaneous Spinal Cord Stimulation ◽  
Spinal Flexion

Transcutaneous spinal cord stimulation is a non-invasive method for neuromodulation of sensorimotor function. Its main mechanism of action results from the activation of afferent fibers in the posterior roots—the same structures as targeted by epidural stimulation. Here, we investigated the influence of sagittal spine alignment on the capacity of the surface-electrode-based stimulation to activate these neural structures. We evaluated electromyographic responses evoked in the lower limbs of ten healthy individuals during extension, flexion, and neutral alignment of the thoracolumbar spine. To control for position-specific effects, stimulation in these spine alignment conditions was performed in four different body positions. In comparison to neutral and extended spine alignment, flexion of the spine resulted in a strong reduction of the response amplitudes. There was no such effect on tibial-nerve evoked H reflexes. Further, there was a reduction of post-activation depression of the responses to transcutaneous spinal cord stimulation evoked in spinal flexion. Thus, afferent fibers were reliably activated with neutral and extended spine alignment. Spinal flexion, however, reduced the capacity of the stimulation to activate afferent fibers and led to the co-activation of motor fibers in the anterior roots. This change of action was due to biophysical rather than neurophysiological influences. We recommend applying transcutaneous spinal cord stimulation in body positions that allow individuals to maintain a neutral or extended spine.

Spinal cord stimulation in peripheral arterial disease

1986 ◽  
Vol 64 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Jaime Broseta ◽  
José Barberá ◽  
J. A. de Vera ◽  
Juan Luis Barcia-Salorio ◽  
Guillermo Garcia-March ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Arterial Disease ◽  
Spinal Cord Stimulation ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Peripheral Blood Flow ◽  
Thoracic Spinal Cord ◽  
Arterial Blood ◽  
Thoracic Spinal ◽  
Peripheral Arterial

✓ Percutaneous epidural Stimulation of the low thoracic spinal cord was carried out in 41 patients with pain from peripheral arterial disease of the lower limbs. Results are reported relating to pain, claudication distance, peripheral blood flow, and trophic lesion changes. Following a trial period of stimulation, 37 patients had stimulators permanently implanted. After a mean poststimulation follow-up period of 25 months, substantial pain relief (75% to 100%) was obtained in 29 cases; claudication distance significantly increased in 15 cases; Doppler ultrasound recordings of lower-limb distal arteries showed a tendency toward normalization of pulse-wave morphology, with increase of amplitude in 12 of the 23 patients studied; a rise in skin temperature was also detected by thermography. Distal arterial blood pressure remained unchanged with stimulation. Ischemic cutaneous trophic lesions of less than 3 sq cm healed, but gangrenous conditions were not benefited. A placebo effect or the natural history of the disease can be excluded as the reason for these improvements. It is concluded that spinal cord stimulation is a valid alternative treatment for moderate peripheral arterial disorders when direct arterial surgery is not possible or has been unsuccessful.

Effect of transcutaneous electrical spinal cord stimulation on the blood flow in the skin of lower limbs

2017 ◽  
Vol 43 (5) ◽  
pp. 518-523 ◽  
Author(s):  
G. I. Lobov ◽  
N. A. Shcherbakova ◽  
R. M. Gorodnichev ◽  
A. A. Grishin ◽  
Y. P. Gerasimenko ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Spinal Cord Stimulation ◽  
Lower Limbs
Sign in / Sign up

Export Citation Format

Share Document