P545 Bolus administration of steroid therapy is more favourable than the conventional use in preventing decrease of bone density and the increase of body fat percentage in patients with inflammatory bowel disease

Abstract Background Anthropometric data and dietary intake pattern are poorly known in Asian inflammatory bowel disease (IBD) patients. The aim of this study was to investigate the nutritional status and nutrient intake of IBD patients compared with control population. Methods From February to June 2018, a total of 65 outpatients, including 33 ulcerative colitis (UC) and 32 Crohn’s disease (CD) were prospectively enrolled in Gangnam Severance Hospital. As a control group, age- and gender-matched 260 subjects were included among the Korean National Health and Nutrition Examination Survey (KNHANES) data. Anthropometry and body composition data were collected by bioelectrical impedance analysis(BIA); meanwhile, nutrient intake was measured based on diet diary. Results Based on Asia Pacific criteria, more than half of both UC and control group were obese or overweight, on the other hands, CD was relatively low, about 1/3. Compared with the UC group, body fat index including both fat mass index (FMI) and body fat percentage (BFP) were significantly lower in the CD group. Following nutrients intake including intake of energy, carbohydrate, niacin, sodium and potassium were significantly lower in UC than the control group. Meanwhile, intake of carbohydrate, thiamine, niacin, sodium, potassium and iron was significantly lower in CD than the control group. In addition, the ratio of energy intake through protein and fat was significantly higher in the IBD than the control group. Conclusion Similar to the control group, more than half of UC patients were overweight or obesity, meanwhile, the proportion of obese patients in CD was lower than in the control group. The ratio of energy intake through protein and fat was significantly higher in IBD than in the control group. Our results may have clinical implications for risk of IBD development in terms of dietary pattern and further direction of nutritional intervention.

Download Full-text

P293 Bone density and bone metabolism in patients with inflammatory bowel disease

Journal of Crohn s and Colitis ◽

10.1016/s1873-9946(13)60314-1 ◽

2013 ◽

Vol 7 ◽

pp. S126-S127

Author(s):

I.A. Pintilie ◽

O. Nedelciuc ◽

A.M. Blaj ◽

C. Mihai ◽

C. Cijevschi Prelipcean

Keyword(s):

Inflammatory Bowel Disease ◽

Bone Density ◽

Bone Metabolism ◽

Bowel Disease ◽

Inflammatory Bowel

Download Full-text

Skip, Stop, Switch, and Spare: Steroid Therapy in Inflammatory Bowel Disease

The American Journal of Gastroenterology ◽

10.14309/ajg.0000000000001380 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Nicole Harrison ◽

Ross Humes ◽

Manish Singla

Keyword(s):

Inflammatory Bowel Disease ◽

Steroid Therapy ◽

Bowel Disease ◽

Inflammatory Bowel

Download Full-text

Profile of nutritional status, energy availability, haemoglobin levels and bone density in santriwati (Islamic female student) with chronic energy deficiency risk

JURNAL GIZI INDONESIA ◽

10.14710/jgi.9.2.97-104 ◽

2021 ◽

Vol 9 (2) ◽

pp. 97-104

Author(s):

Fillah Fithra Dieny ◽

A Fahmy Arif Tsani ◽

Umu Faradilla ◽

Ayu Rahadiyanti

Keyword(s):

At Risk ◽

Bone Density ◽

Energy Expenditure ◽

Energy Intake ◽

Body Fat ◽

Female Student ◽

Female Students ◽

Body Fat Percentage ◽

Energy Availability ◽

Fat Percentage

Background: Santriwati (Islamic female student), women of reproductive age, were susceptible to experienced Chronic Energi Deficiency (CED). CED reflects the low energy availability of someone who can risk reducing bone density. Objectives: This study aimed to analyze the differences in body mass index, body fat percentage, hemoglobin levels, energy availability, and bone mineral density of female students who experienced CED risk and not experienced CED risk.Materials and Methods: The research design was a cross-sectional study, with 101 female students as subjects who were selected by random sampling. The research was conducted from February to March 2019 at the Kyai Galang Sewu Islamic Boarding School, Semarang. CED risk data was taken using the upper arm circumference measurement. Percent body fat and BMI data were taken using BIA. Energy availability data is obtained from the difference between energy intake (energy intake) and energy output (energy expenditure through physical activity) divided by Fat-Free Mass (FFM). Energy intake data was taken using the SQ-FFQ questionnaire, and energy expenditure was calculated using the 24-hour activity record form. Anemia data were collected using strip hemoglobin measurements. Bone density data were taken using the Osteosys Sonost 3000 densitometer. Bivariate analysis used the Independent T-Test.Results: A total of 57.2% of subjects experienced anemia. Subjects who had underweight nutritional status were 20.8%. Santriwati experienced osteopenia as much as 13.9%. There was no difference in bone density and hemoglobin levels between female students who were at risk of CED and not CED risk (p> 0.05), but there were differences in energy availability, body fat percentage, BMI between those at risk of CED and not CED risk (p <0.05)Conclusion: subjects at risk of CED (Lila <23.5 cm) had lower energy availability, body fat, and BMI than subjects who were not at risk of CED.

Download Full-text

All Patients with Inflammatory Bowel Disease Should Have Bone Density Assessment: Pro

Inflammatory Bowel Diseases ◽

10.1097/00054725-200105000-00012 ◽

2001 ◽

Vol 7 (2) ◽

pp. 158-162 ◽

Cited By ~ 17

Author(s):

Alexandra Papaioannou ◽

Nicole C. Ferko ◽

J. D. Adachi

Keyword(s):

Inflammatory Bowel Disease ◽

Bone Density ◽

Bowel Disease ◽

Inflammatory Bowel ◽

Density Assessment

Download Full-text

Decreased bone density in inflammatory bowel disease is related to corticosteroid use and not disease diagnosis

Journal of Bone and Mineral Research ◽

10.1002/jbmr.5650100211 ◽

2009 ◽

Vol 10 (2) ◽

pp. 250-256 ◽

Cited By ~ 154

Author(s):

Charles N. Bernstein ◽

Leanne L. Seeger ◽

James W. Sayre ◽

Peter A. Anton ◽

Lucy Artinian ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bone Density ◽

Bowel Disease ◽

Disease Diagnosis ◽

Inflammatory Bowel

Download Full-text

Risk Factors for Low Bone Density in Inflammatory Bowel Disease: Use of Glucocorticoids, Low Body Mass Index, and Smoking

Digestive Diseases ◽

10.1159/000496935 ◽

2019 ◽

Vol 37 (4) ◽

pp. 284-290 ◽

Cited By ~ 7

Author(s):

Razi Even Dar ◽

Yoav Mazor ◽

Amir Karban ◽

Sofia Ish-Shalom ◽

Elena Segal

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Inflammatory Bowel Disease ◽

Bone Density ◽

Body Mass ◽

Bowel Disease ◽

Mineral Density ◽

Low Bone Density ◽

Low Body Mass Index ◽

Inflammatory Bowel

Background: Inflammatory bowel disease (IBD) patients are reported to have lower bone density compared to healthy controls. There is limited consensus regarding factors affecting bone density among these patients. Our aim, therefore, was to determine clinical and genetic variables that contribute to lower bone mineral density (BMD) in IBD patients. Methods: A cross-sectional study of IBD patients treated in a tertiary referral center was performed. Epidemiological and clinical data were collected, and genetic testing for the common mutations in Nucleotide-binding Oligomerization Domain-containing protein (NOD)2 was performed. We examined correlations between the different variables and BMD in the total hip, femoral neck, and lumbar spine. Results: Eighty-nine patients (49% males, 67 Crohn’s disease [CD]) participated in the study. 42Forty-two (63%) of the CD and 13 (59%) of the ulcerative colitis patients met the criteria for osteoporosis/osteopenia. Factors associated with lower Z scores were low body mass index (BMI; r = –0.307, p = 0.005), use of glucocorticoids (likelihood ratio [LR] 5.1, p = 0.028), and a trend for male gender (LR = 3.4, p = 0.079). Among CD patients, low bone density showed borderline significance for association with gastrointestinal surgery (LR = 4.1, p = 0.07) and smoking (LR = 3.58, p = 0.06). Low levels of 25OHD were not associated with low BMD, nor were mutations in NOD2. No increased rate of fractures was seen among patients with osteopenia or osteoporosis. Conclusion: In addition to the generally accepted risk factors for osteoporosis (glucocorticoids, low BMI, smoking), male IBD patients had a trend toward lower BMD. Carrying a mutaticon in NOD2 did not confer a risk for bone loss.

Download Full-text