Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19

Background: Nonalcoholic fatty liver disease (NAFLD) is a kind of metabolic stress-induced liver injury closely related to insulin resistance and genetic susceptibility, and there is no specific drug for its clinical treatment currently. In recent years, a large amount of literature has reported that many natural compounds extracted from traditional Chinese medicine (TCM) can improve NAFLD through various mechanisms. According to the latest reports, some emerging natural compounds have shown great potential to improve NAFLD but are seldom used clinically due to the lacking special research. Purpose: This paper aims to summarize the molecular mechanisms of the potential natural compounds on improving NAFLD, thus providing a direction and basis for further research on the pathogenesis of NAFLD and the development of effective drugs for the prevention and treatment of NAFLD. Methods: By searching various online databases, such as Web of Science, SciFinder, PubMed, and CNKI, NAFLD and these natural compounds were used as the keywords for detailed literature retrieval. Results: The pathogenesis of NAFLD and the molecular mechanisms of the potential natural compounds on improving NAFLD have been reviewed. Conclusion: Many natural compounds from traditional Chinese medicine have a good prospect in the treatment of NAFLD, which can serve as a direction for the development of anti-NAFLD drugs in the future.

Download Full-text

Prevention and Treatment of Diabetic Nephropathy Using Traditional Chinese Medicine

Journal of Integrative Nephrology and Andrology ◽

10.4103/2225-1243.143374 ◽

2014 ◽

Vol 1 (2) ◽

pp. 53 ◽

Cited By ~ 1

Author(s):

Xuemei Zhang ◽

Wen Peng ◽

Peihao Yin ◽

Xia Chen ◽

Aili Cao ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Prevention And Treatment

Download Full-text

Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives

Natural Product Communications ◽

10.1177/1934578x1601101130 ◽

2016 ◽

Vol 11 (11) ◽

pp. 1934578X1601101 ◽

Cited By ~ 1

Author(s):

Di Yang ◽

Wanwan Jia ◽

Yi Zhun Zhu

Keyword(s):

Natural Products ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Therapeutic Potential ◽

Biological Activities ◽

Future Perspectives ◽

Effective Agent ◽

Recent Advances

Herba Leonuri, also named Chinese Motherwort, has been extensively investigated as an effective agent on the uterus system. Our group has been studying the natural products of Herba Leonuri for several years, and during this period, many biological activities of the drug were recognized. Leonurine (4-guanidino- N-butyl-syringate) is an alkaloid present in Herba Leonuri. Recently, growing evidence has highlighted the therapeutic potential of leonurine in multiple diseases, especially cardiovascular. In this review, we discuss the biological activities of leonurine, as well as recent advances involving this alkaloid.

Download Full-text

Recent Advances in Traditional Chinese Medicine for Kidney Disease

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2015.04.013 ◽

2015 ◽

Vol 66 (3) ◽

pp. 513-522 ◽

Cited By ~ 49

Author(s):

Yifei Zhong ◽

Madhav C. Menon ◽

Yueyi Deng ◽

Yiping Chen ◽

John Cijiang He

Keyword(s):

Chinese Medicine ◽

Kidney Disease ◽

Traditional Chinese Medicine ◽

Recent Advances

Download Full-text

Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

Journal of Immunology Research ◽

10.1155/2020/9680508 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Yongwang Yan ◽

Xu Zhou ◽

Kangxiao Guo ◽

Feng Zhou ◽

Hongqi Yang

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Diabetic Nephropathy ◽

Peripheral Neuropathy ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Chlorogenic Acid ◽

Pharmacological Properties ◽

Prevention And Treatment ◽

Main Component

Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifically, CA relieves the effects of, and prevents, diabetes mellitus (DM). In addition, CA is also beneficial against complications arising from DM, such as diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN). Herein, we review the use of CA in the prevention and treatment of DM and its complications, providing a background for further research and medical uses.

Download Full-text

Correlation between Traditional Chinese Medicine Constitution and Dyslipidemia: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/1896746 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Ye-lin Ma ◽

Hui Yao ◽

Wei-jia Yang ◽

Xuan-xuan Ren ◽

Long Teng ◽

...

Keyword(s):

Systematic Review ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

North China ◽

Protective Factor ◽

Meta Analysis ◽

High Quality ◽

Prevention And Treatment ◽

Chinese Medicine Constitution ◽

Review Manager

Objective. To study the correlation between Traditional Chinese Medicine (TCM) constitution and dyslipidemia. Methods. CNKI, VIP, Wanfang database, CBMdisc, PubMed, and Embase were searched, and meta-analysis was performed by Review Manager 5.2 software. Results. Altogether 11 studies were included with 12890 individuals. The results showed that balanced constitution was a protective factor of dyslipidemia (OR = 0.62, 95% CI 0.47~0.82) while phlegm-dampness constitution was a risk factor of it (OR = 2.50, 95% CI 2.22~2.80), and the effect of phlegm-dampness constitution in South China (OR = 3.31, 95% CI 1.71~6.43) was more obvious than that in East (OR = 2.40, 95% CI 2.06~2.80) and North China (OR = 2.24, 95% CI 1.81~2.78). Conclusion. This study provides evidence for the prevention and treatment of dyslipidemia in TCM. However, most of the studies included are of moderate quality; more high quality, multicenter, large-sample studies are expected to provide higher level evidence.

Download Full-text