scholarly journals Intensification of antiretroviral treatment with raltegravir for pregnant women living with HIV at high risk of vertical transmission

2018 ◽  
Vol 4 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Thanyawee Puthanakit ◽  
Nattawan Thepnarong ◽  
Surasith Chaithongwongwatthana ◽  
Suvaporn Anugulruengkitt ◽  
Orawan Anunsittichai ◽  
...  
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Antiretroviral Treatment ◽  
Women Living With Hiv ◽  
Living With Hiv

Social Vulnerability among Foreign-Born Pregnant Women and Maternal Virologic Control of HIV

2020 ◽  
Author(s):  
Ashish Premkumar ◽  
Lynn M. Yee ◽  
Lia Benes ◽  
Emily S. Miller
Keyword(s):  
Antiretroviral Therapy ◽  
Pregnant Women ◽  
Median Time ◽  
Social Vulnerability ◽  
Viral Suppression ◽  
Foreign Born ◽  
Women Living With Hiv ◽  
Virologic Control ◽  
Clinical Records ◽  
Living With Hiv

Objective The aim of this study was to assess whether social vulnerability among foreign-born pregnant women living with HIV is associated with maternal viremia during pregnancy. Study Design This retrospective cohort study included all foreign-born pregnant women living with HIV who received prenatal care in a multidisciplinary prenatal clinic between 2009 and 2018. A licensed clinical social worker evaluated all women and kept detailed clinical records on immigration status and social support. Social vulnerability was defined as both living in the United States for less than 5 years and reporting no family or friends for support. The primary outcome was evidence of viral non-suppression after achievement of initial suppression. Secondary outcomes were the proportion of women who required > 12 weeks after starting antiretroviral therapy to achieve viral suppression, median time to first viral suppression (in weeks) after initiation of antiretroviral therapy, and the proportion who missed ≥ 5 doses of antiretroviral therapy. Bivariable analyses were performed. Results A total of 111 foreign-born women were eligible for analysis, of whom 25 (23%) were classified as socially vulnerable. Social and clinical characteristics of women diverged by social vulnerability categorization but no differences reached statistical significance. On bivariable analysis, socially-vulnerable women were at increased risk for needing > 12 weeks to achieve viral suppression (relative risk: 1.78, 95% confidence interval: 1.18–2.67), though there was no association with missing ≥ 5 doses of antiretroviral therapy or median time to viral suppression after initiation of antiretroviral therapy. Conclusion Among foreign-born, pregnant women living with HIV, markers of virologic control during pregnancy were noted to be worse among socially-vulnerable women. Insofar as maternal viremia is the predominant driver of perinatal transmission, closer clinical surveillance and support may be indicated in this population. Key Points

scholarly journals Feasibility of SMS to remind pregnant and breastfeeding women living with HIV to take antiretroviral treatment in Kilimanjaro region, Tanzania: a pilot study

2020 ◽  
Vol 4 (2) ◽  
pp. 140-148
Author(s):  
Kennedy M Ngowi ◽  
Eusebious Maro ◽  
Rob E Aarnoutse ◽  
Blandina T Mmbaga ◽  
Mirjam A. G Sprangers ◽  
...  
Keyword(s):  
Pilot Study ◽  
Antiretroviral Treatment ◽  
Network Failure ◽  
Women Living With Hiv ◽  
Resource Limited ◽  
Sms Reminders ◽  
Kilimanjaro Christian Medical Centre ◽  
Living With Hiv ◽  
Lost To Follow Up ◽  
Privacy Issues

Background: Pregnant and breastfeeding Women Living with HIV (WLHIV) often have difficulties in reaching adequate levels of adherence (>95%) to Antiretroviral treatment. “Forgetting” is the most commonly mentioned reason. Sending reminders via SMS is expected to improve adherence. We conducted a pilot study to investigate acceptability, user experience and technical feasibility of sending reminder-SMS to WLHIV. Methods: This was a 6-months observational pilot-study among WLHIV attending antenatal and postnatal care at Kilimanjaro Christian Medical Centre in Moshi, Tanzania. Women received a reminder-SMS 30 minutes before usual time of intake. One hour later, they received an SMS asking whether they took medication to which they could reply with ‘Yes’ or ‘No’. Messages were sent 3 times a week on randomly chosen days to prevent reliance on daily messages. We calculated the percentage of number of SMS delivered, failed to be delivered, and replied to. We analysed feedback from exit-interviews about experience with the SMS-reminders. Results: 25 women were enrolled (age 18-45), 2 were lost to follow up. 5,054 messages were sent of which 53 failed to be delivered (1%). 1,880 SMS were sent with a question if medication was taken; 1,012 (54%) messages were replied to, of which 1,003 (99%) were replied with ‘YES’ and closely to ‘YES’, and a total of 9 (1%) with ‘NO’ and ‘closely to NO’. 868 messages (46%) were not responded to due to either dropout, change of phone number, loss of phone or network failure. Results from 18 interviews showed that 16 (89%) women were satisfied with SMS reminders. 2 (11%) were concerned about unwanted disclosure because of the content ‘don’t forget to take medication’ and one reported other privacy issues (6%). 3 (17%) women experienced stigma. Conclusion: 99%of SMS being delivered indicates that SMS reminders in this resource-limited setting are technically feasible. However, concerns regarding privacy were noted, specifically the risk of unwanted disclosure and the experience of stigma. Participants indicated that being made aware of their adherence, motivated them to adhere better. However, personalised and more neutral content of the SMS might be a way to improving the intervention.

scholarly journals Quality of Life of Pregnant Women Living with HIV/AIDS

2016 ◽  
Vol 38 (05) ◽  
pp. 246-252 ◽  
Author(s):  
Mariângela Silveira ◽  
Cristina Müller ◽  
Marysabel Silveira
Keyword(s):  
Quality Of Life ◽  
Pregnant Women ◽  
Women Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Two-years persistence of anal high-risk HPV infections in women living with HIV, results from the EVVA study

2018 ◽  
Vol 5 ◽  
pp. S12
Author(s):  
Alexandra de Pokomandy ◽  
Alexandra de Pokomandy ◽  
Bernard Lessard ◽  
Marie-Hélène Mayrand ◽  
Louise Charest ◽  
...  
Keyword(s):  
High Risk ◽  
Women Living With Hiv ◽  
High Risk Hpv ◽  
Living With Hiv

Group Antenatal Care for Improving Retention of Adolescent and Young Pregnant Women Living With HIV in Kenya

2021 ◽  
Author(s):  
Chloe A. Teasdale ◽  
Judith Odondi ◽  
Catherine Kidiga ◽  
Michelle Choy ◽  
Ruby Fayorsey ◽  
...  
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Women Living With Hiv ◽  
Living With Hiv

Antiretroviral Therapy in Pregnant Women

2019 ◽  
pp. 281-286
Author(s):  
William R. Short ◽  
Jason J. Schafer
Keyword(s):  
Clinical Trials ◽  
Pregnant Women ◽  
Hiv Transmission ◽  
Pediatric Aids ◽  
Women Living With Hiv ◽  
Pivotal Study ◽  
Aids Clinical Trials ◽  
Living With Hiv ◽  
Mother To Child ◽  
Over Time

Upon completion of this chapter, the reader should be able to describe the appropriate management of antiretrovirals for pregnant women living with HIV. Over time, research has demonstrated that proper prevention strategies and interventions during pregnancy, labor, and delivery can significantly reduce the rate of mother-to-child transmission (MTCT) of HIV. In 1994, a pivotal study in the field of HIV medicine, the Pediatric AIDS Clinical Trials Group 076, demonstrated that the use of zidovudine (ZDV) monotherapy during pregnancy substantially reduced the risk of HIV transmission to infants by 67% (...

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