scholarly journals Construction of a telomerase-immortalized porcine tracheal epithelial cell model for swine-origin mycoplasma infection

2022 ◽  
Vol 21 (2) ◽  
pp. 504-520
Author(s):  
Xing XIE ◽  
Fei HAO ◽  
Hai-yan WANG ◽  
Mao-da PANG ◽  
Yuan GAN ◽  
...  
1993 ◽  
Vol 94 (1) ◽  
pp. 73-80
Author(s):  
Peter C. Möller ◽  
Louise C. Henson ◽  
Brooks Rogers ◽  
Michael J. Evans

2003 ◽  
Vol 285 (2) ◽  
pp. L405-L414 ◽  
Author(s):  
Jennifer E. Foster ◽  
Katherine Gott ◽  
Mark R. Schuyler ◽  
Wieslaw Kozak ◽  
Yohannes Tesfaigzi

Our previous studies show that Bcl-2, a regulator of apoptosis, may be involved in the reduction of mucous cell metaplasia (MCM) during recovery from inflammatory responses. The present study was to determine whether neutrophilic inflammation mediates Bcl-2 expression in mucous cells. Rats were intratracheally instilled with 50–1,000 μg of LPS. The number of neutrophils recovered by bronchoalveolar lavage (BAL) increased with the dose of LPS, and the percentage of Bcl-2-expressing cells increased with the numbers of neutrophils in the BAL. Depletion of neutrophils did not reduce MCM, but the percentage of Bcl-2-positive cells increased 1.8-fold in neutrophil-depleted compared with controls. Injection of rats with bezafibrate, an inducer of cytochrome P-450, doubled the number of neutrophils in the BAL, decreased MCM twofold compared with vehicle-injected controls, and reduced Bcl-2 expression. Bcl-2 mRNA levels decreased in a tracheal epithelial cell line treated with bezafibrate. These data demonstrate that Bcl-2 expression is independent of the number of neutrophils in the BAL and that bezafibrate may directly reduce Bcl-2 expression in epithelial cells.


1991 ◽  
Vol 23 (4) ◽  
pp. 427-435 ◽  
Author(s):  
P.C. Moller ◽  
J.S. Bergmann ◽  
M.J. Evans ◽  
B.W. Weaver ◽  
R.L. Given ◽  
...  

1996 ◽  
Vol 14 (2) ◽  
pp. 146-154 ◽  
Author(s):  
S H Randell ◽  
J Y Liu ◽  
P C Ferriola ◽  
L Kaartinen ◽  
M M Doherty ◽  
...  

1982 ◽  
Vol 3 (11) ◽  
pp. 1283-1287 ◽  
Author(s):  
Alan Eastman ◽  
Brooke T. Mossman ◽  
Edward Bresnick

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