Liver transplantation in patients with alcohol-related liver disease: current status and future directions

Chronic hepatitis B infection is a global public health problem associated with significant morbidity and mortality. Persistent infection may evolve to liver cirrhosis and hepatocellular carcinoma, and hepatitis B-related liver disease is a common indication for liver transplantation. Patients with advanced liver disease should be treated with antiviral therapy which may result in clinical improvement. The management of patients after liver transplant then focuses on preventing hepatitis B recurrence in the graft. With the introduction of prophylactic treatment, patient and graft survival has improved significantly. In this review, we will discuss the management of patients with hepatitis B-related cirrhosis, both compensated and decompensated. We also review the management of hepatitis B after liver transplantation.

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Challenges in Liver Transplantation for Common Variable Immunodeficiency-related Liver Disease a Case Series and Systematic Review

Journal of Liver Transplantation ◽

10.1016/j.liver.2021.100038 ◽

2021 ◽

pp. 100038

Author(s):

Thomas Henry Tranah ◽

Zillah Cargill ◽

Oliver Tavabie ◽

Ghulam Mufti ◽

Varuna Aluvihare ◽

...

Keyword(s):

Systematic Review ◽

Liver Transplantation ◽

Liver Disease ◽

Common Variable Immunodeficiency ◽

Case Series ◽

Related Liver Disease ◽

Common Variable

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Liver disorders

Best of Five MCQS for the European Specialty Examination in Gastroenterology and Hepatology ◽

10.1093/oso/9780198834373.003.0008 ◽

2021 ◽

pp. 208-258

Author(s):

Thomas Marjot

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Core Curriculum ◽

Chronic Viral Hepatitis ◽

Alcoholic Fatty Liver ◽

Liver Disorders ◽

Bacterial Peritonitis ◽

Complications Of Cirrhosis ◽

Related Liver Disease ◽

Curriculum Topics

This chapter covers core curriculum topics relating to liver disorders including the anatomy, physiology, and biochemistry of the liver as it relates to disease processes. There is a focus on the investigation and management of acute hepatitis including viral, drug- and toxin-induced, and the risk stratification of patients with acute liver failure. All major chronic liver diseases are discussed including non-alcoholic fatty liver disease, autoimmune liver disease, alcohol related liver disease and chronic viral hepatitis. There is also education on managing the complications of cirrhosis including renal dysfunction, hepatic encephalopathy, variceal haemorrhage, and spontaneous bacterial peritonitis. Additional important topics covered include nutrition in liver disease, hepatocellular carcinoma, liver transplantation indications and assessment, and complications following liver transplantation. Additional curriculum material regarding liver disorders will also be covered in the mock examination chapter.

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Tacrolimus exposure after liver transplantation for alcohol-related liver disease: Impact on complications

Transplant Immunology ◽

10.1016/j.trim.2019.101227 ◽

2019 ◽

Vol 56 ◽

pp. 101227 ◽

Cited By ~ 4

Author(s):

Franck-Nicolas Bardou ◽

Olivier Guillaud ◽

Domitille Erard-Poinsot ◽

Christine Chambon-Augoyard ◽

Elsa Thimonier ◽

...

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Disease Impact ◽

Related Liver Disease

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A novel scoring system for predicting risk of relapse following referral for liver transplantation in patients with alcohol-related liver disease

Journal of Hepatology ◽

10.1016/s0168-8278(20)31062-x ◽

2020 ◽

Vol 73 ◽

pp. S279-S280

Author(s):

Stephanie Turner ◽

Ellie van der List ◽

Kate Forgan-Smith ◽

Maree Jarrett ◽

Katherine Stuart

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Scoring System ◽

Related Liver Disease ◽

Risk Of Relapse

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An Overview of Current Status, Recent Techniques and Challenges of Liver Transplantation

International Journal of Applied Sciences and Biotechnology ◽

10.3126/ijasbt.v6i2.20417 ◽

2018 ◽

Vol 6 (2) ◽

pp. 67-74

Author(s):

Bharata Regmi ◽

Manoj Kumar Shah

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Deceased Donor ◽

Current Status ◽

Organ Shortage ◽

Donor Organ ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Split Liver

A liver transplantation (LT) is a surgical procedure that removes a liver that no longer functions properly and replaces it with a healthy liver from a living or deceased donor. It is a viable treatment option for end-stage liver disease and acute liver failure. The most commonly used technique is orthotopic transplantation or deceased donor liver transplantation (DDLT) in which the native liver is removed and replaced by the donor organ in the same anatomic location as the original liver. Ongoing challenges of LT include those concerning donor organ shortages, recipients with more advanced disease at transplant, growing need for transplantation, side effects associated with long-term immunosuppression, toxicities and obesity. Organ shortage has become the most vexing problem in LT, with 10–25% of patients dying while awaiting transplantation. Different ideas has been evolved like living donor liver transplantation (LDLT), marginal donor liver transplantation (MDLT) and split liver transplantation (SLT) to overcome the growing problem of organ shortage. These techniques are becoming very important in an attempt to narrow the gap between demand and supply of organs. The advances in surgical and anaesthetic techniques, greater understanding of the physiological, haematological, biochemical, microbiological and immunological changes in liver disease and transplantation allowed a multidisciplinary approach that led to better outcomes. These changes, coupled with more effective immunosuppressive and anti-microbial agents and improvements in patient and donor selection, mean that now liver replacement is a routine procedure with excellent long term outcomes.Int. J. Appl. Sci. Biotechnol. Vol 6(2): 67-74

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