Bone modeling and remodeling in the skeleton of a supernumerary digit of a child affected by segmental gigantism

Bone ◽  
1996 ◽  
Vol 19 (3) ◽  
pp. 151
Author(s):  
F. Marotti ◽  
C. Palumbo ◽  
M.F. Bertolani
Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 157 ◽  
Author(s):  
Beth Lee

Skeletal quantity and quality are determined by processes of bone modeling and remodeling, which are undertaken by cells that build and resorb bone as they respond to mechanical, hormonal, and other external and internal signals. As the sole bone resorptive cell type, osteoclasts possess a remarkably dynamic actin cytoskeleton that drives their function in this enterprise. Actin rearrangements guide osteoclasts’ capacity for precursor fusion during differentiation, for migration across bone surfaces and sensing of their composition, and for generation of unique actin superstructures required for the resorptive process. In this regard, it is not surprising that myosins, the superfamily of actin-based motor proteins, play key roles in osteoclast physiology. This review briefly summarizes current knowledge of the osteoclast actin cytoskeleton and describes myosins’ roles in osteoclast differentiation, migration, and actin superstructure patterning.


1991 ◽  
Vol 54 (1) ◽  
pp. 17-23 ◽  
Author(s):  
A.M. Ubios ◽  
M.B. Guglielmotti ◽  
T. Steimetz ◽  
R.L. Cabrini

2006 ◽  
Vol 51 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Alejandro A. Gorustovich ◽  
Tammy Steimetz ◽  
Máximo J. Giglio ◽  
María B. Guglielmotti

Theranostics ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 426-436 ◽  
Author(s):  
Yi Peng ◽  
Song Wu ◽  
Yusheng Li ◽  
Janet L. Crane

2010 ◽  
Vol 1 (1) ◽  
pp. 51-53
Author(s):  
Surekha R Puranik ◽  
Satwinder Singh ◽  
Mangala Rakaraddi

ABSTRACT Osteopetrosis is a disease characterized by failure of osteoclasts of bone as a consequence bone modeling and remodeling is impaired, characteristically resulting in skeletal fragility despite of increased density, which also cause hematopoietic insufficiency, disturbed tooth eruption, nerve disturbances, syndrome and growth impairment. Human OP is a heterogeneous genetic disorder encompassing different molecular lesions and range of clinical features, which share single pathogenic nexus in the osteoclasts. We present a rare case of osteopetrosis in a 10-year-old boy with a palatal bony and infraorbital inflammatory swellings. The characteristic clinical, radiologic, and laboratory evaluation confirmed the diagnosis of intermediate osteopetrosis.


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