Background:
Piperine, a bioactive alkaloid was a well-known component which was used
traditionally to treat a variety of disorders.
Objective:
The present review is to discuss the modified piperine or piperic acid analogs or its derivatives
to explore the potential of piperine. Piperine or piperic acid had potentials as antibacterial, antitumor,
antioxidant, anti-inflammatory, antifungal, immunomodulatory and many more for drug development.
So modification in natural molecule piperine generates numerous derivatives or analogues which
may be found beneficial in drug development.
Methods:
A literature survey has been carried out to determine the real potential of piperine and its
modified analogs.
Results:
It has been scrutinized that piperine and its derivatives possess valuable components with good
therapeutic potential.
Conclusion:
Thus, this review aims to provide knowledge as well as to explore the excellent potential
of piperine, piperic acid, piperine derived compounds/ analogs which may further, after performing
toxicity studies, and other parameters, be helpful in the design and development of novel drug candidates
against numerous disease conditions and thus it paves way for further work in exploring the potential
to treat the patients with obesity and skin related disorders.
Anticancer efficacy and absorption, distribution, metabolism, and toxicity studies of Aspergiolide A in early drug development
