scholarly journals 3367 A Mouse Model of APOE Genotype in Chemotherapy Related Cognitive Impairment

2019 ◽  
Vol 3 (s1) ◽  
pp. 1-1
Author(s):  
Tamar Demby ◽  
G. William Rebeck ◽  
Christopher Albanese ◽  
Olga C. Rodriguez ◽  
Yichien Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Cognitive Impairment ◽  
Cancer Survivors ◽  
Open Field ◽  
Breast Cancer Survivors ◽  
Apoe Genotype ◽  
Post Treatment ◽  
Barnes Maze ◽  
Doxorubicin Treatment

OBJECTIVES/SPECIFIC AIMS: Chemotherapy-related cognitive impairment (CRCI) affects 15-35% of breast cancer survivors and constitutes a significant challenge for survivor quality of life. Among older breast cancer survivors who received chemotherapy treatment, carriers of at least one ɛ4 allele of the APOE gene, which encodes apolipoprotein E, are at higher risk for developing CRCI than non-carriers. APOE4 is well characterized as the strongest genetic risk factor for Alzheimer’s disease, but how it contributes to CRCI is not yet understood, and no animal models of APOE genotype and CRCI have yet been established. To better understand how APOE4 acts as a risk factor for CRCI, we used APOE targeted replacement (TR) mice to develop a model of its effects on cognition following treatment with doxorubicin, a chemotherapy drug commonly used in breast cancer treatment. METHODS/STUDY POPULATION: Twelve-to-thirteen month old APOE3 and APOE4 targeted replacement mice expressing human APOE3 or human APOE4 under control of the endogenous murine promoter were treated with 10 mg/kg doxorubicin or equivolume saline given via two IP injections spaced one week apart. One week post-treatment, mice were tested using Open Field and Elevated Zero apparatuses to assess baseline locomotive activity and anxiety and exploratory behaviors. Five weeks post-treatment, mice were assessed using the Barnes Maze over four days of training trials and one 72 hour memory probe. RESULTS/ANTICIPATED RESULTS: We found no differences in Open Field and Elevated Zero behavior, indicating limited influence of doxorubicin treatment on locomotive and anxiety behaviors in both genotypes. During Barnes Maze training, APOE4 mice treated with doxorubicin showed increased latency compared to untreated APOE4 mice as well as treated and untreated APOE3 mice, indicating deficiencies in spatial learning. In APOE3 mice, no differences in performance were seen between doxorubicin-treated and untreated mice (n = 15-16/group, p <.0001). DISCUSSION/SIGNIFICANCE OF IMPACT: These results indicate that APOE4 targeted replacement mice have specific cognitive vulnerabilities to doxorubicin treatment that can be reliably detected using the Barnes Maze assessment. Future directions include experiments to determine how other chemotherapy drugs or drug combinations impact cognition of APOE4 mice. Ultimately this model may be used to assess preventive measures or therapies for CRCI in the vulnerable APOE4 carrier population with the ability to validate cognitive impacts of these interventions.

scholarly journals 1030 An Exploration of the Impact of Cognitive Behavioural Therapy of Insomnia (CBT-I) on Perceived Cognitive Impairment in Breast Cancer Survivors

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A391-A392
Author(s):  
N Walsh ◽  
S Garland ◽  
R Lester ◽  
J McCarthy ◽  
K Laing
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Post Treatment ◽  
Subjective Cognitive Function ◽  
The Impact ◽  
Insomnia Severity

Abstract Introduction Insomnia and cognitive impairment are prevalent and persistent symptoms in cancer survivors. Cognitive Behavior Therapy is effective for improving insomnia and comorbid symptoms in cancer survivors but there are very few empirically supported treatments that can improve cognitive impairment. This feasibility study explored the impact of CBT-I on perceived cognitive impairment in breast cancer survivors. Methods We enrolled 10 early stage breast cancer survivors with insomnia disorder and perceived cognitive impairment. Participants received 7 individual sessions of CBT-I over the course of 8 weeks and completed the Insomnia Severity Index (ISI), the Functional Assessment of Cancer Therapy - Cognitive Function (FACT-Cog) questionnaires and The Hospital Anxiety and Depression Scale (HADS) at baseline and post-treatment. Paired samples t-tests were used to assess change over time. Results The sample was predominantly diagnosed with stage II breast cancer (60%). Women were an average age of 50.8 (SD 6.84) and 18.2 (SD 3.62) years of education. CBT-I significantly reduced insomnia severity [19.4 to 7.1; t(9)= 6.56, p &lt; .001] and improved perceived cognitive impairment [t(9)= -3.55, p &lt; .01], perceived cognitive ability [t(9)= -2.87, p &lt; .05], quality of life [t(9)= -3.14, p &lt; .05], and overall subjective cognitive function [t(9)= -3.67, p &lt; .01]. Although participants began treatment with low levels of mood disturbance, CBT-I further decreased symptoms of anxiety (baseline: M= 10.10, SD= 4.34; post-treatment M= 8.20, SD= 3.91) and depression (baseline: M= 7.90, SD= 3.45; post-treatment M= 5.30, SD= 2.83), although not statistically significant. Conclusion This study suggests CBT-I may improve perceived cognitive impairment in cancer survivors, in addition to insomnia and mood. Future randomized controlled trials with larger samples and objective measurements of cognition are needed. Support Nyissa Walsh is a trainee in the Cancer Research Training Program of the Beatrice Hunter Cancer Research Institute (BHCRI). Dr. Sheila Garland is supported by a Scotiabank New Investigator Award from BHCRI.

scholarly journals The impact of cognitive impairment on self‐regulatory styles in breast cancer survivors

2021 ◽  
Author(s):  
Jacqueline H. Becker ◽  
Charlotte Ezratty ◽  
Nusrat Jahan ◽  
Mita Goel ◽  
Yael Tobi Harris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Regulatory Styles ◽  
The Impact

scholarly journals Effect of Tai Chi Chuan practice on immune system and pro-metastasis markers in early post-treatment breast cancer survivors

2021 ◽  
Vol 12 (1) ◽  
pp. 013-019
Author(s):  
Mary NB Cheung ◽  
Wings Tjing Yung Loo
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Complete Blood Count ◽  
Post Treatment ◽  
Control Group ◽  
Wait List ◽  
Tai Chi Chuan

Purpose: To investigate the effect of Tai Chi Chuan (TCC) to improve immune system and decrease pro-metastasis markers in early post-treatment breast cancer survivors. Methods: 130 post-treatment breast cancer survivors were recruited and randomized 1:1 into TCC group and wait-list (control) group. The TCC group practiced for a 60-minutes session once per week, for a total of 52 weeks. 115 forms of Yang-style TCC were taught by a Tai Chi master. Blood samples were taken from each subject and complete blood count was performed. The expressions of NKG2D protein, P-selectin, and vascular endothelial growth factor (VEGF) in plasma were measured. Lymphocyte activity was measured by cell proliferation reagent and ATP assay. Images of lymphocyte colony formation were taken with an inverted microscope. Results: At 52 weeks, TCC group demonstrated a significantly higher WBC (p=0.001) , a significantly higher NKG2D value (p=0.001) and a significantly lower VEGF value (p=0.005) when compared to the wait-list group. However, there was a small, non-significant change for P-selectin values between the breast cancer survivor groups. After 72h incubation, TCC group had a significant increase in lymphocyte proliferation (p=0.001) and greater area of lymphocyte clusters or colonies (p=0.001). Conclusion: The practice of TCC could stimulate tumor immunosurveillance via NKG2D and activate the immune response. VEGF, a marker playing an important role in breast cancer and its metastases, was also reduced in those who practiced TCC. As an alternative for conventional exercise, post-treatment breast cancer survivors may select TCC in their rehabilitation program.

scholarly journals Therapies for cognitive impairment in breast cancer survivors treated with chemotherapy

Medicine ◽  
2020 ◽  
Vol 99 (19) ◽  
pp. e20092
Author(s):  
Qiuhua Zhang ◽  
Xiufei Gao ◽  
Shan Liu ◽  
Linghong Yu ◽  
Jiayan Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Cancer Survivors ◽  
Breast Cancer Survivors

Cognitive Impairment in Breast Cancer Survivors

2016 ◽  
pp. 399-419 ◽  
Author(s):  
Michael J. Mackenzie ◽  
Krystle E. Zuniga ◽  
Edward McAuley
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Cancer Survivors ◽  
Breast Cancer Survivors

scholarly journals Evaluation of the delivery of survivorship care plans for South Asian female breast cancer survivors residing in Canada

2018 ◽  
Vol 25 (4) ◽  
Author(s):  
S. Singh-Carlson ◽  
F. Wong ◽  
G. Oshan
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
South Asian ◽  
Breast Cancer Survivors ◽  
Family Members ◽  
Female Breast Cancer ◽  
Post Treatment ◽  
Survivorship Care ◽  
Female Breast

Background This paper focuses on phase iii of a study evaluating the development and implementation of a survivorship care plan (scp) that could ultimately improve post-treatment quality of life for South Asian (sa) breast cancer survivors (bcss). Evaluating the utility of the scp was important to understand how sociocultural influences might affect uptake of the scp by sa bcss, especially as they transition from treatment to community care.Methods Post-treatment discharge planning using an individualized scp at discharge for sa female breast cancer patients with stage i or ii disease was offered as a pilot service to oncologists at BC Cancer’s Fraser Valley and Abbotsford centres. A longitudinal study using a mixed-methods approach was used to evaluate the utility of that service at 1 year after discharge.Results Participants (n = 16) completed a survey about their scp delivery experience, and a 1-year post implementation survey about the scp content and its utility. Most participants reported the discharge appointments to be extremely or very helpful with respect to post-treatment care questions. All have visited their family physicians for follow-up as recommended. The three major sources of support were family, faith, and family physician. Qualitative responses from the health care professionals who developed or implemented the scps identified two challenges in scp delivery: engaging patients or family members in relationship, and translating key information through interpreters.Conclusions It is important to evaluate the utility of scps for sa female survivors, who might differ from the general bcs population because of a different understanding of the disease; language barriers; strong influence of family members; societal stigmas; and personal, social, cultural, and religious beliefs and values. A formal nurse-led discharge appointment with discussions about follow-up care and an individualized scp outlining the short- and long-term effects of treatment are recommended. Particular attention has to be paid to the practical and psychosocial needs of sa bcss and their supporting family members.

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