scholarly journals Effect of Tai Chi Chuan practice on immune system and pro-metastasis markers in early post-treatment breast cancer survivors

2021 ◽  
Vol 12 (1) ◽  
pp. 013-019
Author(s):  
Mary NB Cheung ◽  
Wings Tjing Yung Loo
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Complete Blood Count ◽  
Post Treatment ◽  
Control Group ◽  
Wait List ◽  
Tai Chi Chuan

Purpose: To investigate the effect of Tai Chi Chuan (TCC) to improve immune system and decrease pro-metastasis markers in early post-treatment breast cancer survivors. Methods: 130 post-treatment breast cancer survivors were recruited and randomized 1:1 into TCC group and wait-list (control) group. The TCC group practiced for a 60-minutes session once per week, for a total of 52 weeks. 115 forms of Yang-style TCC were taught by a Tai Chi master. Blood samples were taken from each subject and complete blood count was performed. The expressions of NKG2D protein, P-selectin, and vascular endothelial growth factor (VEGF) in plasma were measured. Lymphocyte activity was measured by cell proliferation reagent and ATP assay. Images of lymphocyte colony formation were taken with an inverted microscope. Results: At 52 weeks, TCC group demonstrated a significantly higher WBC (p=0.001) , a significantly higher NKG2D value (p=0.001) and a significantly lower VEGF value (p=0.005) when compared to the wait-list group. However, there was a small, non-significant change for P-selectin values between the breast cancer survivor groups. After 72h incubation, TCC group had a significant increase in lymphocyte proliferation (p=0.001) and greater area of lymphocyte clusters or colonies (p=0.001). Conclusion: The practice of TCC could stimulate tumor immunosurveillance via NKG2D and activate the immune response. VEGF, a marker playing an important role in breast cancer and its metastases, was also reduced in those who practiced TCC. As an alternative for conventional exercise, post-treatment breast cancer survivors may select TCC in their rehabilitation program.

scholarly journals The Influence Of Tai Chi Chuan On Inflammatory Profiles And Cardiovascular Function Among Breast Cancer Survivors

2009 ◽  
Vol 41 ◽  
pp. 9
Author(s):  
Karen M. Mustian ◽  
Tom Darling ◽  
Michelle Janelsins ◽  
Jeffrey Katula ◽  
Laurie Wideman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Cardiovascular Function ◽  
Tai Chi Chuan

scholarly journals Yoga's Impact on Inflammation, Mood, and Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial

2014 ◽  
Vol 32 (10) ◽  
pp. 1040-1049 ◽  
Author(s):  
Janice K. Kiecolt-Glaser ◽  
Jeanette M. Bennett ◽  
Rebecca Andridge ◽  
Juan Peng ◽  
Charles L. Shapiro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Short Form ◽  
Post Treatment ◽  
Control Group ◽  
Yoga Practice ◽  
Randomized Controlled ◽  
Yoga Group ◽  
Tnf Α

Purpose To evaluate yoga's impact on inflammation, mood, and fatigue. Patients and Methods A randomized controlled 3-month trial was conducted with two post-treatment assessments of 200 breast cancer survivors assigned to either 12 weeks of 90-minute twice per week hatha yoga classes or a wait-list control. The main outcome measures were lipopolysaccharide-stimulated production of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β), and scores on the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), the vitality scale from the Medical Outcomes Study 36-item Short Form (SF-36), and the Center for Epidemiological Studies-Depression (CES-D) scale. Results Immediately post-treatment, fatigue was not lower (P > .05) but vitality was higher (P = .01) in the yoga group compared with the control group. At 3 months post-treatment, fatigue was lower in the yoga group (P = .002), vitality was higher (P = .01), and IL-6 (P = .027), TNF-α (P = .027), and IL-1β (P = .037) were lower for yoga participants compared with the control group. Groups did not differ on depression at either time (P > .2). Planned secondary analyses showed that the frequency of yoga practice had stronger associations with fatigue at both post-treatment visits (P = .019; P < .001), as well as vitality (P = .016; P = .0045), but not depression (P > .05) than simple group assignment; more frequent practice produced larger changes. At 3 months post-treatment, increasing yoga practice also led to a decrease in IL-6 (P = .01) and IL-1β (P = .03) production but not in TNF-α production (P > .05). Conclusion Chronic inflammation may fuel declines in physical function leading to frailty and disability. If yoga dampens or limits both fatigue and inflammation, then regular practice could have substantial health benefits.

scholarly journals Tai Chi Chuan for Breast Cancer Survivors

2008 ◽  
pp. 209-217 ◽  
Author(s):  
Karen M. Mustian ◽  
Oxana G. Palesh ◽  
Stephanie A. Flecksteiner
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Tai Chi Chuan

scholarly journals Effects of Tai Chi Chuan on Insulin and Cytokine Levels in a Randomized Controlled Pilot Study on Breast Cancer Survivors

2011 ◽  
Vol 11 (3) ◽  
pp. 161-170 ◽  
Author(s):  
Michelle C. Janelsins ◽  
Paul G. Davis ◽  
Laurie Wideman ◽  
Jeffrey A. Katula ◽  
Lisa K. Sprod ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pilot Study ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Tai Chi Chuan ◽  
Randomized Controlled ◽  
Cytokine Levels

Tai Chi Chuan and Insulin-Like Growth Factor-I (IGF-I) in Breast Cancer Survivors

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S97-S98
Author(s):  
Paul G. Davis ◽  
Karen M. Mustian ◽  
Jeffery A. Katula ◽  
Laurie Wideman
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Insulin Like Growth Factor ◽  
Tai Chi Chuan ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Tai Chi Chuan and Insulin-Like Growth Factor-I (IGF-I) in Breast Cancer Survivors

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S97???S98
Author(s):  
Paul G. Davis ◽  
Karen M. Mustian ◽  
Jeffery A. Katula ◽  
Laurie Wideman
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Insulin Like Growth Factor ◽  
Tai Chi Chuan ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

scholarly journals Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan

2011 ◽  
Vol 6 (2) ◽  
pp. 146-154 ◽  
Author(s):  
Lisa K. Sprod ◽  
Michelle C. Janelsins ◽  
Oxana G. Palesh ◽  
Jennifer K. Carroll ◽  
Charles E. Heckler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Health Related Quality ◽  
Tai Chi Chuan ◽  
Related Quality ◽  
Health Related

scholarly journals The Evolution of Mindfulness-Based Physical Interventions in Breast Cancer Survivors

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Daniela L. Stan ◽  
Nerissa M. Collins ◽  
Molly M. Olsen ◽  
Ivana Croghan ◽  
Sandhya Pruthi
Keyword(s):  
Breast Cancer ◽  
Physical Exercise ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Tai Chi ◽  
Moderate Intensity ◽  
Cancer Treatments ◽  
Tai Chi Chuan ◽  
Exercise Interventions ◽  
Reasonable Evidence

Survivors of breast cancer are faced with a multitude of medical and psychological impairments during and after treatment and throughout their lifespan. Physical exercise has been shown to improve survival and recurrence in this population. Mind-body interventions combine a light-moderate intensity physical exercise with mindfulness, thus having the potential to improve both physical and psychological sequelae of breast cancer treatments. We conducted a review of mindfulness-based physical exercise interventions which included yoga, tai chi chuan, Pilates, and qigong, in breast cancer survivors. Among the mindfulness-based interventions, yoga was significantly more studied in this population as compared to tai chi chuan, Pilates, and qigong. The participants and the outcomes of the majority of the studies reviewed were heterogeneous, and the population included was generally not selected for symptoms. Yoga was shown to improve fatigue in a few methodologically strong studies, providing reasonable evidence for benefit in this population. Improvements were also seen in sleep, anxiety, depression, distress, quality of life, and postchemotherapy nausea and vomiting in the yoga studies. Tai chi chuan, Pilates, and qigong were not studied sufficiently in breast cancer survivors in order to be implemented in clinical practice.

scholarly journals Effects of exercise in breast cancer patients: implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial

2021 ◽  
Author(s):  
Roxanne Gal ◽  
Evelyn M. Monninkhof ◽  
Carla H. van Gils ◽  
Rolf H. H. Groenwold ◽  
Sjoerd G. Elias ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Beneficial Effect ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Exercise Intervention ◽  
Intervention Group ◽  
Control Group ◽  
Physical Fatigue ◽  
Trials Within Cohorts

Abstract Purpose The Trials within Cohorts (TwiCs) design aims to overcome problems faced in conventional RCTs. We evaluated the TwiCs design when estimating the effect of exercise on quality of life (QoL) and fatigue in inactive breast cancer survivors. Methods UMBRELLA Fit was conducted within the prospective UMBRELLA breast cancer cohort. Patients provided consent for future randomization at cohort entry. We randomized inactive patients 12–18 months after cohort enrollment. The intervention group (n = 130) was offered a 12-week supervised exercise intervention. The control group (n = 130) was not informed and received usual care. Six-month exercise effects on QoL and fatigue as measured in the cohort were analyzed with intention-to-treat (ITT), instrumental variable (IV), and propensity scores (PS) analyses. Results Fifty-two percent (n = 68) of inactive patients accepted the intervention. Physical activity increased in patients in the intervention group, but not in the control group. We found no benefit of exercise for dimensions of QoL (ITT difference global QoL: 0.8, 95% CI = − 2.2; 3.8) and fatigue, except for a small beneficial effect on physical fatigue (ITT difference: − 1.1, 95% CI = − 1.8; − 0.3; IV: − 1.9, 95% CI = − 3.3; − 0.5, PS: − 1.2, 95% CI = − 2.3; − 0.2). Conclusion TwiCs gave insight into exercise intervention acceptance: about half of inactive breast cancer survivors accepted the offer and increased physical activity levels. The offer resulted in no improvement on QoL, and a small beneficial effect on physical fatigue. Trial registration Netherlands Trial Register (NTR5482/NL.52062.041.15), date of registration: December 07, 2015.

Sign in / Sign up

Export Citation Format

Share Document