scholarly journals Effectiveness of steroid treatment for SARS-CoV-2 pneumonia with COP-like reaction: a case report

2020 ◽  
pp. 1-13
Author(s):  
Taehwa Kim ◽  
Eunjeong Son ◽  
Doosoo Jeon ◽  
Su Jin Lee ◽  
Seungjin Lim ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Responses ◽  
Clinical Course ◽  
Steroid Treatment ◽  
Lung Damage ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Steroid Administration ◽  
Anti Inflammatory

Abstract Several studies on the treatment of coronavirus disease (COVID-19) are being conducted, and various drugs are being tried; however, the results have not been uniform. Steroids have been widely used in the treatment of COVID-19, but their effects are controversial. As immunosuppressive and anti-inflammatory agents, steroids are considered to reduce lung damage by regulating various inflammatory responses. We report a case of severe acute respiratory syndrome coronavirus-2 pneumonia manifesting as a cryptogenic organizing pneumonia-like reaction and discuss its treatment, clinical course, and favorable outcomes after steroid administration.

scholarly journals Antiseptic Effect of Ps-K18: Mechanism of Its Antibacterial and Anti-Inflammatory Activities

2019 ◽  
Vol 20 (19) ◽  
pp. 4895 ◽  
Author(s):  
Mihee Jang ◽  
Jieun Kim ◽  
Yujin Choi ◽  
JeongKyu Bang ◽  
Yangmee Kim
Keyword(s):  
Septic Shock ◽  
Antibacterial Activity ◽  
Bioactive Peptides ◽  
Liver Toxicity ◽  
Inflammatory Responses ◽  
Lung Damage ◽  
Peptide Antibiotic ◽  
Gram Negative ◽  
Innate Defense ◽  
Anti Inflammatory

Recently, bioactive peptides have attracted attention for their therapeutic applications in the pharmaceutical industry. Among them, antimicrobial peptides are candidates for new antibiotic drugs. Since pseudin-2 (Ps), isolated from the skin of the paradoxical frog Pseudis paradoxa, shows broad-spectrum antibacterial activity with high cytotoxicity, we previously designed Ps-K18 with a Lys substitution for Leu18 in Ps, which showed high antibacterial activity and low toxicity. Here, we examined the potency of Ps-K18, aiming to develop antibiotics derived from bioactive peptides for the treatment of Gram-negative sepsis. We first investigated the antibacterial mechanism of Ps-K18 based on confocal micrographs and field emission scanning electron microscopy, confirming that Ps-K18 targets the bacterial membrane. Anti-inflammatory mechanism of Ps-K18 was investigated by secreted alkaline phosphatase reporter gene assays and RT-PCR, which revealed that Ps-K18 activates innate defense via Toll-like receptor 4-mediated nuclear factor-kappa B signaling pathways. Moreover, we investigated the antiseptic effect of Ps-K18 using a lipopolysaccharide or Escherichia coli K1-induced septic shock mouse model. Ps-K18 significantly reduced bacterial growth and inflammatory responses in the septic shock model. Ps-K18 showed low renal and liver toxicity and attenuated lung damage effectively. This study suggests that Ps-K18 is a potent peptide antibiotic that could be applied therapeutically to Gram-negative sepsis.

Nodular Cryptogenic Organizing Pneumonia: A Case Report

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. A192
Author(s):  
Xiao-yan Zhang ◽  
Bei Wang ◽  
Li-Yuan Zheng ◽  
Qian-Qian Feng ◽  
Qianli Ma ◽  
...  
Keyword(s):  
Case Report ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia

scholarly journals Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Stefanie Krug ◽  
Sadiya Parveen ◽  
William R. Bishai
Keyword(s):  
Immune Response ◽  
Inflammatory Responses ◽  
Lung Damage ◽  
Tb Treatment ◽  
Inflammatory Processes ◽  
Clinical Models ◽  
Human Immune Response ◽  
Human Immune ◽  
Anti Inflammatory ◽  
Microbiological Cure

Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), most human hosts are able to contain the infection and avoid progression to active TB disease through expression of a balanced, homeostatic immune response. Proinflammatory mechanisms aiming to kill, slow and sequester the pathogen are key to a successful host response. However, an excessive or inappropriate pro-inflammatory response may lead to granuloma enlargement and tissue damage, which may prolong the TB treatment duration and permanently diminish the lung function of TB survivors. The host also expresses certain anti-inflammatory mediators which may play either beneficial or detrimental roles depending on the timing of their deployment. The balance between the timing and expression levels of pro- and anti-inflammatory responses plays an important role in the fate of infection. Interestingly, M. tuberculosis appears to manipulate both sides of the human immune response to remodel the host environment for its own benefit. Consequently, therapies which modulate either end of this spectrum of immune responses at the appropriate time may have the potential to improve the treatment of TB or to reduce the formation of permanent lung damage after microbiological cure. Here, we highlight host-directed TB therapies targeting pro- or anti-inflammatory processes that have been evaluated in pre-clinical models. The repurposing of already available drugs known to modulate these responses may improve the future of TB therapy.

Cryptogenic organizing pneumonia in Sweet's syndrome: case report and review of the literature

2014 ◽  
Vol 10 (2) ◽  
pp. 250-254 ◽  
Author(s):  
Elias Tzelepis ◽  
Christos F. Kampolis ◽  
Ioanna Vlachadami ◽  
Maria Moschovi ◽  
Maria Alamani ◽  
...  
Keyword(s):  
Case Report ◽  
Sweet’S Syndrome ◽  
Organizing Pneumonia ◽  
Review Of The Literature ◽  
Cryptogenic Organizing Pneumonia ◽  
Sweet's Syndrome

P-263: Cryptogenic organizing pneumonia: a rare syndrome even in the elderly. Case report

2015 ◽  
Vol 6 ◽  
pp. S102 ◽  
Author(s):  
S. Zannoni ◽  
C. Lorenzi ◽  
M. Paoli ◽  
F. Orso ◽  
M. Torrini ◽  
...  
Keyword(s):  
Case Report ◽  
The Elderly ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Rare Syndrome

scholarly journals An unexplained death after routine cardiac surgery: how long have we dealt with coronavirus disease 2019?

2020 ◽  
Vol 31 (6) ◽  
pp. 904-905
Author(s):  
Laura Varela Barca ◽  
Isabel Torralba Cloquell ◽  
Jaime Herrero Cereceda ◽  
Jose Ignacio Sáez de Ibarra
Keyword(s):  
Cardiac Surgery ◽  
Case Report ◽  
Respiratory Failure ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Course ◽  
Epidemiological Data ◽  
Spike Protein ◽  
Post Mortem ◽  
Immunohistochemical Detection ◽  
Unexplained Death

Abstract We present a case report of fatal respiratory failure after cardiac surgery in the early stages of the coronavirus disease 2019 outbreak. Although not supported by epidemiological data nor clinical course, coronavirus disease 2019 infection was revealed post-mortem by immunohistochemical detection of the severe acute respiratory syndrome coronavirus 2 spike protein in lung tissue.

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