Overweight or obesity are not risk factors for central venous catheter–related bloodstream infections in patients with hematological malignancies

The risks and microbiology for peripherally inserted central catheters (PICCs) are less well described than those for traditional central catheters, particularly as they pertain to duration of catheterization. We compared patients with early- and late-onset PICC bloodstream infections at our institution and found significant differences in microbiologic etiologies.

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Risk factors for central venous catheter–related bloodstream infections after gastrointestinal surgery

American Journal of Infection Control ◽

10.1016/j.ajic.2017.01.007 ◽

2017 ◽

Vol 45 (5) ◽

pp. 549-550 ◽

Cited By ~ 6

Author(s):

Shenghai Wu ◽

Shuhua Ren ◽

Hongfeng Zhao ◽

Huicheng Jin ◽

Lihui Xv ◽

...

Keyword(s):

Risk Factors ◽

Central Venous Catheter ◽

Gastrointestinal Surgery ◽

Bloodstream Infections ◽

Venous Catheter ◽

Central Venous

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Determination of a Cutoff Time Point for Prophylactic Exchange of Central Venous Catheters for Prevention of Central Venous Catheter–Related Bloodstream Infections in Patients with Hematological Malignancies

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2017.92 ◽

2017 ◽

Vol 38 (7) ◽

pp. 888-889

Author(s):

Enrico Schalk ◽

Lena M. Biehl ◽

Jacqueline Färber ◽

Dirk Schlüter ◽

Maria J. G. T. Vehreschild ◽

...

Keyword(s):

Central Venous Catheter ◽

Hematological Malignancies ◽

Bloodstream Infections ◽

Venous Catheter ◽

Central Venous Catheters ◽

Central Venous ◽

Time Point

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Patient- and Device-Specific Risk Factors for Peripherally Inserted Central Venous Catheter—Related Bloodstream Infections

Infection Control and Hospital Epidemiology ◽

10.1086/669083 ◽

2013 ◽

Vol 34 (2) ◽

pp. 184-189 ◽

Cited By ~ 24

Author(s):

Makhawadee Pongruangporn ◽

M. Cristina Ajenjo ◽

Anthony J. Russo ◽

Kathleen M. McMullen ◽

Catherine Robinson ◽

...

Keyword(s):

Risk Factors ◽

Central Venous Catheter ◽

Tertiary Care ◽

Bloodstream Infections ◽

Venous Catheter ◽

Adult Patients ◽

Chronic Obstructive ◽

Central Venous ◽

Obstructive Pulmonary Disease ◽

Specific Risk

Objective.To determine the patient- and device-specific risk factors for hospital-acquired peripherally inserted central venous catheter–related bloodstream infections (PICC BSIs) in adult patients.Design.Nested case-control study.Setting.Barnes-Jewish Hospital, a 1,252-bed tertiary care teaching hospital.Patients.Adult patients with PICCs placed from January 1, 2006, through July 31, 2008.Methods.PICC BSI cases were identified using the National Healthcare Safety Network definition. Uninfected control patients with PICCs in place were randomly selected at a 3: 1 ratio. Patient- and device-related variables were examined using multivariate analysis.Results.The overall PICC BSI rate was 3.13 per 1,000 catheter-days. Independent risk factors for PICC BSIs included congestive heart failure (odds ratio [OR], 2.0 [95% confidence interval (CI), 1.26–3.17];P= .003), intra-abdominal perforation (OR, 5.66 [95% CI, 1.76–18.19];P= .004),Clostidium difficileinfection (OR, 2.25 [95% CI, 1.17–4.33];P= .02), recent chemotherapy (OR, 3.36 [95% CI, 1.15–9.78];P= .03), presence of tracheostomy (OR, 5.88 [95% CI, 2.99–11.55];P< .001), and type of catheter (OR for double lumen, 1.89 [95% CI, 1.15–3.10];P= .01; OR for triple lumen, 2.87 [95% CI, 1.39–5.92];P= .004). Underlying chronic obstructive pulmonary disease (OR, 0.48 [95% CI, 0.29–0.78];P= .03) and admission to surgical (OR, 0.43 [95% CI, 0.24–0.79];P= .006) or oncology and orthopedic (OR, 0.35 [95% CI, 0.13–0.99];P= .05) services were less likely to be associated with having a PICC BSI.Conclusions.We identified several novel factors related to PICC BSIs. These factors may inform preventive measures.

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Clinical and financial implications of central venous catheters bloodstream infections in patients with multiple myeloma in the United States.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e20033 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e20033-e20033

Author(s):

Pool Tobar ◽

Luis F. Gonzalez Mosquera ◽

Diana D. Cardenas Maldonado ◽

Bernard Moscoso ◽

Alida I. Podrumar ◽

...

Keyword(s):

Risk Factors ◽

Multiple Myeloma ◽

Weight Loss ◽

Central Venous Catheter ◽

Bloodstream Infections ◽

Venous Catheter ◽

The United States ◽

Central Venous ◽

Predictors Of Mortality ◽

Poor Outcome

e20033 Background: Multiple Myeloma(MM) has an increased exposure to intravascular catheters due to the increased risk of severe infections and due to the route of treatment administration. Central Venous Catheter Bloodstream Infections(CVCBI) have significant mortality, imply a delay in treatment and increased cost as well. There is no prior report on the risk factors for poor outcome in MM patients that develop this complication. We aim to describe the predictors of mortality as well as the changes in cost that CVCBI implies. Methods: We retrieved adult patients with MM from the Nationwide Inpatient Sample database from 2016-2018. We used the ICD-10 codes to identify and compare patients who developed CVCBI with those that did not developed it. The main outcomes were hospital mortality and predictors of mortality. We computed the chi-squared test and the Mann-Whitney U-test. Mortality predictors are estimated using multivariate logistic regression and logistic fixed-effect methods to control for admission cohort and hospital time invariant characteristics. All analyses were performed using Stata Statistical Software version 14 (StataCorp, College Station, TX). Results: A total of 58,838 patients with MM were identified. The majority were white (63.5%), male (55.3%), with a median age of 70 (IQR 62-78). Most MM were not in remission (99.1%), followed by those in remission (1.3%) and relapse (0.3%). CVCBI was diagnosed in 264 (0.4%) of the MM patients. There was significantly higher mortality in the CVCBI group vs. the non-CVCBI group (8.7% vs. 5%; p < 0.01), longer LOS (10 vs. 5 days; p < 0.001), and higher median hospitalization cost (US$86,168 vs. US$43,511; p < 0.001). In the multivariable analysis, CVCBI was associated with higher mortality (OR: 1.69; CI 95%: 1.14-2.52; p < 0.001). Among patients with MM and CVCBI those that had achieved remission had a higher risk of death (OR: 2.87; CI 95%: 2.17-3.8; p < 0.001). Other variables associated with mortality were age > 65 (OR: 1.84; CI 95%: 1.59-2.15; p < 0.001), concomitant chronic heart failure (CHF) (OR: 1.46; CI 95%: 1.29-1.65; p < 0.001), chronic kidney disease (CKD) (OR: 1.43; CI 95%: 1.32-1.56; p < 0.001), and weight loss (OR: 2.31; CI 95%: 1.91-2.8; p < 0.001). When compared to medicare patients with higher mortality were more likely to be under medicaid(OR: 1.25; CI 95%: 1.02-1.55; p < 0.05) and private insurances(OR: 1.31; CI 95%: 1.15-1.49; p < 0.001). There was no significant association with sex, race/ethinicity or household income. Conclusions: In patients with Multiple Myeloma the development of Central Venous Catheter Bloodstream Infections was associated with a higher overall mortality, length of stay and cost of hospitalization. Age, CHF, CKD and weight loss were independent risk factors for poor outcome in this patient population. Further studies are required on developing strategies for the prevention of this complication.

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