Genetic Variance and Heritability of Cardiovascular Risk Factors in Chinese Adolescent Twins

1984 ◽  
Vol 33 (3) ◽  
pp. 363-373 ◽  
Author(s):  
C.J. Chen ◽  
B.H. Cohen ◽  
E.L. Diamond ◽  
T.M. Lin ◽  
J.S. Chen
Keyword(s):  
Blood Pressure ◽  
Environmental Factors ◽  
Serum Cholesterol ◽  
Genetic Variance ◽  
Dietary Preference ◽  
Chinese Adolescent ◽  
Taipei City ◽  
Anthropometric Characteristics ◽  
Heritability Estimates ◽  
Adolescent Twins

AbstractIn order to estimate genetic variance and heritability of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels, a total of 235 (79 male and 82 female MZ, 41 male and 33 female DZ) twin pairs, recruited from 12 junior high schools in Taipei city, were studied. Statistically significant genetic variance observed for SBP, DBP, serum cholesterol and triglycerides persisted after adjustment for age and anthropometric characteristics. However, further adjustment for dietary preference, beverage consumption, and other host and environmental factors gave different results: genetic variance of adjusted SBP and DBP was still significant, while significance was found only in males for cholesterol and in neither males nor females for triglycerides. Heritability estimates of unadjusted SBP, DBP, cholesterol and triglycerides were 0.27, 0.45, 0.21 and 0.41, respectively, for males, and 0.15, 0.42, 0.41 and 0.82, respectively, for females. After adjustment for age, anthropometric characteristics, host and environmental factors, the heritability estimates of SBP, DBP and cholesterol were 0.64, 0.72 and 0.50, respectively, for males, and 0.40, 0.60 and 0.37, respectively, for females.

Effects of Gene-Environment Interactions on Cardiovascular Risk Factors in Chinese Adolescent Twins

1984 ◽  
Vol 33 (3) ◽  
pp. 383-396
Author(s):  
C.J. Chen ◽  
B.H. Cohen ◽  
E.L. Diamond ◽  
T.M. Lin ◽  
J.S. Chen
Keyword(s):  
Blood Pressure ◽  
Serum Cholesterol ◽  
Population Based ◽  
Serum Triglycerides ◽  
Gene Environment ◽  
Chinese Adolescent ◽  
Environmental Agents ◽  
Animal Organ ◽  
Adolescent Twins ◽  
The Impact

AbstractA population-based sample of 73 male and 77 female monozygotic (MZ), and 41 male and 33 female dizygotic (DZ) Chinese adolescent twin pairs were studied to assess effects of gene-environment interactions of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels. Intrapair concordance in BP levels was found to be significantly associated with the interaction of zygosity and salty foods preference and also with that of zygosity and vegetable preference. A consistently positive and statistically significant association was observed between the intrapair difference in serum cholesterol and the interaction of zygosity and animal organ preference; while intrapair concordance in serum cholesterol was associated with the interaction of zygosity and milk consumption. Intrapair difference in serum triglycerides was associated with the interaction of zygosity and fish preference, and a significant association was also found between the intrapair concordance in serum triglycerides and the interaction of zygosity and sweets preference. These observations suggest that the impact of these environmental agents may be influenced by the genotype.

Chronological Changes in Genetic Variance and Heritability of Anthropometric Characteristics Among Chinese Twin Infants

1990 ◽  
Vol 39 (4) ◽  
pp. 479-484 ◽  
Author(s):  
C.J. Chen ◽  
M.W. Yu ◽  
C.J. Wang ◽  
S.L. Tong ◽  
M. Tien ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Genetic Variance ◽  
Teaching Hospitals ◽  
Arm Circumference ◽  
Taipei City ◽  
Anthropometric Characteristics ◽  
Gestational Week ◽  
Genetic And Environmental Factors ◽  
One Year ◽  
Major General

AbstractIn order to examine the chronologic changes in genetic variance and heritability of anthropometric characteristics of Chinese infants in Taiwan, a total of 521 pairs of same-sexed twin neonates given birth in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 428 MZ and 93 DZ twin pairs were identified and followed up to the age of one year. There was no significant genetic variance for all anthropometric characteristics adjusted for sex and gestational week before the age of six months. After adjusting for sex and gestational week, a significant genetic variance was observed at the age of six months, with heritability values of 0.51 (weight), 0.63 (head circumference), 0.77 (chest circumference), and 0.53 (arm circumference), as well as at one year, although with considerably lower heritability values. This implies that growth is dynamically determined by both genetic and environmental factors during infancy.

Chronological Changes in Genetic Variance and Heritability of Systolic and Diastolic Blood Pressure Among Chinese Twin Neonates

1990 ◽  
Vol 39 (1) ◽  
pp. 99-108 ◽  
Author(s):  
M.-W. Yu ◽  
C.-J. Chen ◽  
C.-J. Wang ◽  
S.-L. Tong ◽  
M. Tien ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Genetic Variance ◽  
Blood Pressure Measurement ◽  
Teaching Hospitals ◽  
Blood Pressure Monitor ◽  
Pressure Monitor ◽  
Taipei City ◽  
One Year ◽  
Major General

AbstractIn order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP) of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.

Genetic Ecology of Hypertension

1973 ◽  
Vol 45 (s1) ◽  
pp. 55s-65s
Author(s):  
Ricardo Cruz-Coke ◽  
Hugo Donoso ◽  
Radek Barrera
Keyword(s):  
Blood Pressure ◽  
Environmental Factors ◽  
Comparative Study ◽  
Genetic Factor ◽  
Genetic Variance ◽  
Major Genes ◽  
Dominant Component ◽  
Environmental Agents ◽  
Factor Constant

1. A comparative study has been made of a population genetically homogeneous living in two adjacent but strongly different ecosystems. 2. Individuals were ‘marked’ with common serologic major genes. 3. The predominant strength of the environmental factors was demonstrated by the observation that when maintaining the genetic factor constant, hypertension appeared in the more advanced (‘acculturated’) Lowland populations. 4. The absence of hypertension was confirmed in Highland isolated primitive peoples. 5. Blood pressure correlation between relatives varied significantly with changing ecosystems. 6. The predominant strength of heredity was nevertheless demonstrated by the fact that in acculturated populations the genetic component of variance was found to be greater than the environmental one, and the dominant component accounted for nearly half the genetic variance. 7. Hypertension appears in the Lowlands to be exclusively associated with some specific genotypes of the Rhesus and MN systems. 8. The determination of blood pressure may be controlled by few major genes operating in given ecosystems under the permissiveness of environmental agents.

scholarly journals Heritability and Environmental Factors Affecting Vitamin D Status in Rural Chinese Adolescent Twins

2009 ◽  
Vol 94 (9) ◽  
pp. 3273-3281 ◽  
Author(s):  
Lester M. Arguelles ◽  
Craig B. Langman ◽  
Adolfo J. Ariza ◽  
Farah N. Ali ◽  
Kimberley Dilley ◽  
...  
Keyword(s):  
Vitamin D ◽  
Environmental Factors ◽  
Vitamin D Status ◽  
Factors Affecting ◽  
Chinese Adolescent ◽  
Adolescent Twins

Environmental Effects on Cardiovascular Risk Factors in Chinese Adolescent Monozygotic Twins

1984 ◽  
Vol 33 (3) ◽  
pp. 375-381 ◽  
Author(s):  
C.J. Chen ◽  
B.H. Cohen ◽  
E.L. Diamond ◽  
T.M. Lin ◽  
J.S. Chen
Keyword(s):  
Blood Pressure ◽  
Control Method ◽  
Monozygotic Twins ◽  
Population Based ◽  
Negative Association ◽  
Negatively Associated ◽  
Chinese Adolescent ◽  
Taipei City ◽  
Fried Foods ◽  
Males And Females

AbstractThe monozygotic (MZ) cotwin control method was employed to elucidate possible environmental determinants of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels. A population-based twin sample of 73 male and 77 females MZ twin pairs was recruited from 12 junior high schools in Taipei city. Intrapair differences in blood pressure were negatively associated with intrapair difference in vegetable preference, attaining significance for DBP in males and SBP in females. Cholesterol was positively associated with milk consumption and preference for sweets, fried foods, meat and fish. A negative association was also observed between choleserol and vegetable preference. These associations for cholesterol were significant in males only. Triglyceride level negatively associated with preferences for sweets and vegetable, attaining significance for vegetables in both males and females and for sweets in males only.

Effects of Menopause on Trends of Serum Cholesterol, Blood Pressure, and Body Mass Index

Circulation ◽  
1996 ◽  
Vol 94 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Masazumi Akahoshi ◽  
Midori Soda ◽  
Eiji Nakashima ◽  
Katsutaro Shimaoka ◽  
Shinji Seto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Serum Cholesterol

scholarly journals SELECTION FOR BLOOD PRESSURE LEVELS IN MICE

Genetics ◽  
1974 ◽  
Vol 76 (3) ◽  
pp. 537-549
Author(s):  
Gunther Schlager
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Genetic Variance ◽  
Additive Genetic Variance ◽  
Population Bottleneck ◽  
Control Line ◽  
Selected Lines ◽  
High Line ◽  
Selection For ◽  
Random Control

ABSTRACT Response to two-way selection for systolic blood pressure was immediate and continuous for about eight generations. In the twelfth generation, the High males differed from the Low males by 38 mmHG; the females differed by 39 mmHg. There was little overlap between the two lines and they were statistically significant from each other and from the Random control line. There appeared to be no more additive genetic variance in the eleventh and twelfth generations. Causes for the cessation of response are explored. This is probably due to a combination of natural selection acting to reduce litter sizes in the Low line, a higher incidence of sudden deaths in the High line, and loss of favorable alleles as both selection lines went through a population bottleneck in the ninth generation.—In the eleventh generation, the selected lines were used to produce F1, F2, and backcross generations. A genetic analysis yielded significant additive and dominance components in the inheritance of systolic blood pressure.

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