Environmental Effects on Cardiovascular Risk Factors in Chinese Adolescent Monozygotic Twins

1984 ◽  
Vol 33 (3) ◽  
pp. 375-381 ◽  
Author(s):  
C.J. Chen ◽  
B.H. Cohen ◽  
E.L. Diamond ◽  
T.M. Lin ◽  
J.S. Chen
Keyword(s):  
Blood Pressure ◽  
Control Method ◽  
Monozygotic Twins ◽  
Population Based ◽  
Negative Association ◽  
Negatively Associated ◽  
Chinese Adolescent ◽  
Taipei City ◽  
Fried Foods ◽  
Males And Females

AbstractThe monozygotic (MZ) cotwin control method was employed to elucidate possible environmental determinants of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels. A population-based twin sample of 73 male and 77 females MZ twin pairs was recruited from 12 junior high schools in Taipei city. Intrapair differences in blood pressure were negatively associated with intrapair difference in vegetable preference, attaining significance for DBP in males and SBP in females. Cholesterol was positively associated with milk consumption and preference for sweets, fried foods, meat and fish. A negative association was also observed between choleserol and vegetable preference. These associations for cholesterol were significant in males only. Triglyceride level negatively associated with preferences for sweets and vegetable, attaining significance for vegetables in both males and females and for sweets in males only.

Effects of Gene-Environment Interactions on Cardiovascular Risk Factors in Chinese Adolescent Twins

1984 ◽  
Vol 33 (3) ◽  
pp. 383-396
Author(s):  
C.J. Chen ◽  
B.H. Cohen ◽  
E.L. Diamond ◽  
T.M. Lin ◽  
J.S. Chen
Keyword(s):  
Blood Pressure ◽  
Serum Cholesterol ◽  
Population Based ◽  
Serum Triglycerides ◽  
Gene Environment ◽  
Chinese Adolescent ◽  
Environmental Agents ◽  
Animal Organ ◽  
Adolescent Twins ◽  
The Impact

AbstractA population-based sample of 73 male and 77 female monozygotic (MZ), and 41 male and 33 female dizygotic (DZ) Chinese adolescent twin pairs were studied to assess effects of gene-environment interactions of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels. Intrapair concordance in BP levels was found to be significantly associated with the interaction of zygosity and salty foods preference and also with that of zygosity and vegetable preference. A consistently positive and statistically significant association was observed between the intrapair difference in serum cholesterol and the interaction of zygosity and animal organ preference; while intrapair concordance in serum cholesterol was associated with the interaction of zygosity and milk consumption. Intrapair difference in serum triglycerides was associated with the interaction of zygosity and fish preference, and a significant association was also found between the intrapair concordance in serum triglycerides and the interaction of zygosity and sweets preference. These observations suggest that the impact of these environmental agents may be influenced by the genotype.

scholarly journals Dietary Influence on Systolic and Diastolic Blood Pressure in the TwinsUK Cohort

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2130 ◽  
Author(s):  
Panayiotis Louca ◽  
Olatz Mompeo ◽  
Emily R. Leeming ◽  
Sarah E. Berry ◽  
Massimo Mangino ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Structural Equation ◽  
Multiple Testing ◽  
Monozygotic Twins ◽  
Population Based ◽  
Female Population ◽  
Equation Modelling ◽  
Dietary Nutrients ◽  
Heritability Analysis ◽  
Predominantly Female

Nutrition plays a key role in blood pressure (BP) regulation. Here, we examine associations between nutrient intakes and BP in a large predominantly female population-based cohort. We assessed the correlation between 45 nutrients (from food frequency questionnaires) and systolic BP/diastolic BP (SBP/DBP) in 3889 individuals from TwinsUK not on hypertensive treatments and replicated in an independent subset of monozygotic twins discordant for nutrient intake (17–242 pairs). Results from both analyses were meta-analysed. For significant nutrients, we calculated heritability using structural equation modelling. We identified and replicated 15 nutrients associated with SBP, 9 also being associated with DBP, adjusting for covariates and multiple testing. 14 of those had a heritable component (h2: 27.1–57.6%). Strong associations with SBP were observed for riboflavin (Beta(SE) = −1.49(0.38), P = 1.00 × 10−4) and tryptophan (−0.31(0.01), P = 5 × 10−4), while with DBP for alcohol (0.05(0.07), P = 1.00 × 10−4) and lactose (−0.05(0.0), P = 1.3 × 10−3). Two multivariable nutrient scores, combining independently SBP/DBP-associated nutrients, explained 22% of the variance in SBP and 13.6% of the variance in DBP. Moreover, bivariate heritability analysis suggested that nutrients and BP share some genetic influences. We confirm current understanding and extend the panel of dietary nutrients implicated in BP regulation underscoring the value of nutrient focused dietary research in preventing and managing hypertension.

Genetic Variance and Heritability of Cardiovascular Risk Factors in Chinese Adolescent Twins

1984 ◽  
Vol 33 (3) ◽  
pp. 363-373 ◽  
Author(s):  
C.J. Chen ◽  
B.H. Cohen ◽  
E.L. Diamond ◽  
T.M. Lin ◽  
J.S. Chen
Keyword(s):  
Blood Pressure ◽  
Environmental Factors ◽  
Serum Cholesterol ◽  
Genetic Variance ◽  
Dietary Preference ◽  
Chinese Adolescent ◽  
Taipei City ◽  
Anthropometric Characteristics ◽  
Heritability Estimates ◽  
Adolescent Twins

AbstractIn order to estimate genetic variance and heritability of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels, a total of 235 (79 male and 82 female MZ, 41 male and 33 female DZ) twin pairs, recruited from 12 junior high schools in Taipei city, were studied. Statistically significant genetic variance observed for SBP, DBP, serum cholesterol and triglycerides persisted after adjustment for age and anthropometric characteristics. However, further adjustment for dietary preference, beverage consumption, and other host and environmental factors gave different results: genetic variance of adjusted SBP and DBP was still significant, while significance was found only in males for cholesterol and in neither males nor females for triglycerides. Heritability estimates of unadjusted SBP, DBP, cholesterol and triglycerides were 0.27, 0.45, 0.21 and 0.41, respectively, for males, and 0.15, 0.42, 0.41 and 0.82, respectively, for females. After adjustment for age, anthropometric characteristics, host and environmental factors, the heritability estimates of SBP, DBP and cholesterol were 0.64, 0.72 and 0.50, respectively, for males, and 0.40, 0.60 and 0.37, respectively, for females.

Glucose tolerance and blood pressure in a population-based cohort study of males and females: the Reykjavik Study

1995 ◽  
Vol 13 (6) ◽  
pp. 581-586 ◽  
Author(s):  
Karl Kristiansson ◽  
Nikulas Sigfusson ◽  
Helgi Sigvaldason ◽  
Gudmundur Thorgeirsson
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Glucose Tolerance ◽  
Population Based ◽  
Males And Females

The effect of known cardiovascular risk factors on carotid-femoral pulse wave velocity in school-aged children: a population based twin study

2014 ◽  
Vol 5 (4) ◽  
pp. 307-313 ◽  
Author(s):  
K. McCloskey ◽  
C. Sun ◽  
A. Pezic ◽  
J. Cochrane ◽  
R. Morley ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Cardiovascular Risk Factors ◽  
Pulse Wave ◽  
Monozygotic Twins ◽  
Population Based

Childhood cardiovascular risk factors affect vascular function long before overt cardiovascular disease. Twin studies provide a unique opportunity to examine the influence of shared genetic and environmental influences on childhood cardiovascular function. We examined the relationship between birth parameters, markers of adiposity, insulin resistance, lipid profile and blood pressure and carotid–femoral pulse wave velocity (PWV), a validated non-invasive measure of arterial stiffness in a healthy cohort of school-aged twin children.PWV was performed on a population-based birth cohort of 147 twin pairs aged 7–11 years. Fasting blood samples, blood pressure and adiposity measures were collected concurrently. Mixed linear regression models were used to account for twin clustering, within- and between-twin pair associations.There were positive associations between both markers of higher adiposity, insulin resistance, elevated triglycerides and PWV, which remained significant after accounting for twin birth-set clustering. There was a positive association between both diastolic and mean arterial blood pressure and PWV in within-pair analysis in dizygotic, but not monozygotic twins, indicating genetic differences evident in dizygotic not monozygotic twins may affect these associations.Increased blood pressure, triglycerides and other metabolic markers are associated with increased PWV in school-aged twins. These results support both the genetic and environmental contribution to higher PWV, as a marker of arterial stiffness, and reiterate the importance of preventing metabolic syndrome from childhood.

Allergic rhinitis and arterial blood pressure: a population-based study

2018 ◽  
Vol 132 (5) ◽  
pp. 418-422 ◽  
Author(s):  
O Sakallioglu ◽  
C Polat ◽  
A Akyigit ◽  
H Cetiner ◽  
S Duzer
Keyword(s):  
Blood Pressure ◽  
Allergic Rhinitis ◽  
Diastolic Blood Pressure ◽  
Arterial Blood Pressure ◽  
Immunoglobulin E ◽  
Population Based ◽  
Population Based Study ◽  
Arterial Blood ◽  
Males And Females

AbstractObjectives:To investigate the likelihood of allergic rhinitis and potential co-morbidities, and to assess whether allergic rhinitis is associated with arterial blood pressure and hypertension.Methods:In this population-based study, 369 adults with allergic rhinitis and asthma were assessed via a questionnaire and immunoglobulin E levels. There were four groups: control (n = 90), allergic rhinitis (n = 99), asthma (n = 87) and hypertension (n = 93). Arterial blood pressure was measured in all groups.Results:There were no significant differences in systolic or diastolic blood pressure between males and females in any group. Pairwise comparisons revealed no significant differences between: the control and allergic rhinitis groups, the control and asthma groups, or the allergic rhinitis and asthma groups. The systolic and diastolic blood pressure values of males and females were significantly higher in the hypertension group than the allergic rhinitis group. There were no significant differences in systolic blood pressure or diastolic blood pressure for seasonal and perennial allergic rhinitis patients.Conclusion:Rhinitis was not associated with increased blood pressure. Allergic rhinitis can coincide with asthma and hypertension. The findings do not support the need for blood pressure follow up in allergic rhinitis patients.

scholarly journals Impact of Immigration on Body Mass Index and Blood Pressure Among Adolescent Males and Females

Hypertension ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 1316-1323 ◽  
Author(s):  
Uri Hamiel ◽  
Orit Pinhas-Hamiel ◽  
Asaf Vivante ◽  
Cole Bendor ◽  
Aya Bardugo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Fold Increase ◽  
Time Lapse ◽  
Population Based ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Range Measurements ◽  
Males And Females

Immigration from one cultural milieu to another has been associated with a greater risk for incident cardio-metabolic morbidity among adults. In this nationwide, population-based, cross-sectional study of data recorded from 1992 to 2016, we assessed the association between body mass index and blood pressure levels among adolescent immigrants, aged 16 to 19 years, of Ethiopian origin, and their secular trend of overweight and obesity. Adolescents of Ethiopian origin were classified as Israeli-born (n=16 153) or immigrants (N=23 487), with stratification by age at immigration. Adolescents whose fathers were at least 3 generations in Israel (n=277 789) served as a comparative group. Hypertensive-range blood pressure values adjusted for age, sex, and height served as outcome. Among adolescents of Ethiopian origin, overweight and obesity (body mass index ≥85th percentile), increased by 2.5 and 4-fold in males and females, respectively, during the study period, compared with a 1.5-fold increase among native Israeli-born males and females. The odds for hypertensive-range measurements increased with the length of residence in Israel: 7.3%, 10.6%, and 14.4% among males who immigrated at ages 12 to 19, 6 to 11.9, and 0 to 5.9 years, respectively; and 11.5%, 16.7%, and 19.3%, respectively, among females. Israeli-born Ethiopians had a significantly higher risk for hypertensive-range measurements at any body mass index level compared with native Israeli-born examinees, after adjusting for sociodemographic factors and health status. In conclusion, among Ethiopian Israeli adolescents, abnormal blood pressure correlates directly with the time-lapse since immigration. Immigrant populations require targeted surveillance and appropriate intervention.

scholarly journals Association between Blood Pressure and Serum Thyroid-Stimulating Hormone Concentration within the Reference Range: A Population-Based Study

2007 ◽  
Vol 92 (3) ◽  
pp. 841-845 ◽  
Author(s):  
Bjørn O. Åsvold ◽  
Trine Bjøro ◽  
Tom I. L. Nilsen ◽  
Lars J. Vatten
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Outcome Measures ◽  
Odds Ratio ◽  
Reference Range ◽  
Positive Association ◽  
Population Based ◽  
Thyroid Stimulating Hormone ◽  
Cross Sectional ◽  
Population Based Study

Abstract Context: The association between thyroid function and blood pressure is insufficiently studied. Objective: The objective of the investigation was to study the association between TSH within the reference range and blood pressure. Design and Setting: This was a cross-sectional, population-based study. Subjects: A total of 30,728 individuals without previously known thyroid disease were studied. Main Outcome Measures: The main outcome measures were mean systolic and diastolic blood pressure and pulse pressure and odds ratio for hypertension (>140/90 mm Hg or current or previous use of antihypertensive medication), according to categories of TSH. Results: Within the reference range of TSH (0.50–3.5 mU/liter), there was a linear increase in blood pressure with increasing TSH. The average increase in systolic blood pressure was 2.0 mm Hg [95% confidence interval (CI) 1.4–2.6 mm Hg] per milliunit per liter increase in TSH among men, and 1.8 mm Hg (95% CI 1.4–2.3 mm Hg) in women. The corresponding increase in diastolic blood pressure was 1.6 mm Hg (95% CI 1.2–2.0 mm Hg) in men and 1.1 mm Hg (95% CI 0.8–1.3 mm Hg) in women. Comparing TSH of 3.0–3.5 mU/liter (upper part of the reference) with TSH of 0.50–0.99 mU/liter (lower part of the reference), the odds ratio for hypertension was 1.98 (95% CI 1.56–2.53) in men and 1.23 (95% CI 1.04–1.46) in women. Conclusion: Within the reference range of TSH, we found a linear positive association between TSH and systolic and diastolic blood pressure that may have long-term implications for cardiovascular health.

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