Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm

The heart is vital for biological function in almost all chordates, including humans. It beats continually throughout our life, supplying the body with oxygen and nutrients while removing waste products. If it stops, so does life. The heartbeat involves precise coordination of the activity of billions of individual cells, as well as their swift and well-coordinated adaption to changes in physiological demand. Much of the vital control of cardiac function occurs at the level of individual cardiac muscle cells, including acute beat-by-beat feedback from the local mechanical environment to electrical activity (as opposed to longer term changes in gene expression and functional or structural remodeling). This process is known as mechano-electric coupling (MEC). In the current review, we present evidence for, and implications of, MEC in health and disease in human; summarize our understanding of MEC effects gained from whole animal, organ, tissue, and cell studies; identify potential molecular mediators of MEC responses; and demonstrate the power of computational modeling in developing a more comprehensive understanding of ‟what makes the heart tick.ˮ

The index of the hearts squad Carnivora, as an indicator of predator ecology

The article presents the results of calculating the heart index of representatives of the order of carnivores, as one of the main morphophysiological indicators of predator activity. Based on the results of the study, the criteria for specific environmental characteristics of predators used for food production and determining the degree of load on the body were determined. To determine these indicators in some representatives of predatory animals obtained in the Amur region weight measurements of the hearts of sexually Mature individuals were performed: Martes zibellina, Meles leucurus, Canis lupus, Lynx lynx, Vulpes vulpes. Weight indicators of the index were carried out by measuring the ratio of the total mass of the organ to the body weight of the animal (organ mass x 100/ total mass of the animal =%). Conditionally dividing the studied predatory species into: small, medium and large, we determined: active predators intensively tracking their prey and leading high physical activity. Specialized predators that get food by sneaking up and chasing for short distances, not able to run for a long time. Predator-gatherers. In which this feature was an adaptive reaction in the course of evolution for the survival of the species in adverse conditions, food competition and settlement of new territories.

Influence of Search, Solve, Create, and Share (SSCS) Learning Models on Critical Thinking Ability and Learning Outcomes of Padamata Students Learning Class V SDN 12 Palu

The purpose of this research is to know the effect of the search, solve, create, and share (SSCS) learning model on critical thinking ability and student learning outcomes in science subjects. The sampling technique is purposive sample population through the experimental method, this research population is the students of class V SDN 12 Palu. Based on the result of data analysis, it can be concluded that: 1) there was the influence of learning model search, solve, create and share (SSCS) to student critical thinking ability on science subjects with human and animal organ material; 2) there was the influence of learning model of search, solve, create and share to student learning outcomes on science subjects with human and animal organ material: 3) the average gain after the posttest in the experimental class was 82.97; 4) the results of observation of teacher activity and observation of student activities can be said to be good.

Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit

Fistula-in-ano (FIA, anal fistula) treatment remains a surgical challenge for coloproctologists. Adipose tissue-derived stem cells (ADSCs) are a new frontier in the treatment of FIA. In this study, we established a FIA model of Japanese rabbit and evaluated the effect of four treatments on fistula healing: ADSC transplantation, acellular small intestinal submucosa (ASIS), noncutting seton, and PBS as negative control. High-throughput RNA sequencing was also performed to investigate the anal tissue (normal and ADSC treatment group) expression profile of mRNA. Our data showed that ADSC treatment had the shortest time to promote fistula healing compared to the other treatments, and fistula filled with new adipose tissue and muscle cells without scar. Gene Ontology (GO) analysis of RNA-seq data showed that the differential genes are enriched in system development and animal organ development. Taken together, our findings demonstrate that ADSCs rapidly promote fistula healing through differentiation, a promising stem cell therapy for FIA. The rabbit is an effective animal model for evaluating FIA therapeutic options.

Pemanfaatan Tanduk Rusa Baldu Untuk Tujuan Perubatan Menurut Perspektif Halal dan Haram

Deer antler velvet is one of the important ingredients used in traditional medicine by many Asean countries including Malaysia. However, there is doubt regarding the halalness of the medicine derived from deer antler velvet taken alive due to the conflict of fatwa. The objective of this paper is to analyse the position of medicine derives from deer antler velvet from Shariah perspectives. The qualitative methode used through documents analysis, interview and observation. The finding shows that the conflict exists because of the different of ijtihad when the deer antler velvet taken from the animal alive. It is due to the issue, whether it hurt the animal or vice versa. Based on the scientific observation, it is proven that deer antler velvet is part of the animal organ and the nerve connected can make the animal suffering if it is taken alive. It is totally different from halal animal fur that remove while they still alive. Thus, any medication derived from deer antler velvet is not permissible and unclean (najs). Alternatively, to make it halal, the animal should be slaughtered before removing the deer antler valvet. Keywords: deer antler velvet, medicine, fatwa, halal, haram ABSTRAK: Tanduk rusa baldu merupakan antara bahan penting yang dimanfaatkan dalam bidang perubatan herba tradisional di kebanyakan negara asia, termasuk di Malaysia. Bagaimanapun, timbul ketidakpastian hukum terhadap ubat tanduk rusa baldu yang dipotong ketika masih hidup, iaitu sama ada ia boleh dikategorikan sebagai produk yang halal atau haram untuk dimanfaatkan, lantaran wujud konflik fatwa di Malaysia mengenainya. Objektif kajian ini adalah bagi menganalisis hukum ubat daripada tanduk rusa baldu menurut perpektif halal dan haram. Bagi mencapai objektif tersebut, kaedah kualitatif digunakan menerusi pendekatan analisis dokumen, temubual dan pemerhatian. Hasil kajian mendapati antara punca perbezaan pendapat fuqaha dalam menentukan hukum tanduk yang dipotong semasa hidup adalah disebabkan ijtihad mereka yang berbeza terhadap tanduk haiwan, iaitu sama ada ia termasuk dalam kategori anggota yang menyakitkan jika dipotong atau tidak menyakitkan. Berdasarkan maklumat saintifik dan pemerhatian, terbukti bahawa tanduk rusa baldu adalah sejenis anggota yang bersaraf dan menyakitkan jika dipotong ketika hidup, dan tidak boleh disamakan dengan kes bulu haiwan halal. Justeru, produk perubatan berasaskan tanduk rusa yang diperolehi secara kaedah pemotongan tersebut adalah haram dan najis. Sebagai alternatif, pengambilan tanduk rusa menerusi kaedah penyembelihan secara syarak boleh menukar statusnya menjadi produk yang halal. Kata kunci: tanduk rusa, baldu, perubatan, fatwa, halal, haram

A dietary pattern rich in animal organ, seafood and processed meat products is associated with newly diagnosed hyperuricaemia in Chinese adults: a propensity score-matched case–control study

Previous studies have indicated that some food items and nutrients are associated with uric acid metabolism in humans. However, little is known about the role of dietary patterns in hyperuricaemia. We designed this case–control study to evaluate the associations between dietary patterns and newly diagnosed hyperuricaemia in Chinese adults. A total of 1422 cases and 1422 controls were generated from 14 538 participants using the 1:1 ratio propensity score matching methods. Dietary intake was assessed using a validated self-administered FFQ. Dietary patterns were derived by factor analysis. Hyperuricaemia was defined as concentrations of serum uric acid higher than 7 mg/dl (416·5 μmol/l) for men and 6 mg/dl (357 μmol/l) for women. Three dietary patterns were derived by factor analysis: sweet pattern; vegetable pattern; animal foods pattern. The animal foods pattern characterised by higher intake of an animal organ, seafood and processed meat products was associated with higher prevalence of newly diagnosed hyperuricaemia (Pfor trend<0·01) after adjustment. Compared with the participants in the lowest quartile of the animal foods pattern, the OR of newly diagnosed hyperuricaemia in the highest quartile was 1·50 (95 % CI 1·20, 1·87). The other two dietary patterns were not associated with the prevalence of newly diagnosed hyperuricaemia after adjustment. In conclusion, a diet rich in animal organ, seafood and processed meat products is associated with higher prevalence of newly diagnosed hyperuricaemia in a Chinese population. Further cohort studies and randomised controlled trials are required to clarify these findings.

PENERAPAN MULTIMEDIA PEMBELAJARAN ILMU PENGETAHUAN ALAM FUNGSI ORGAN TUBUH MANUSIA DAN HEWAN BERBASIS FLSAH UNTUK KELAS V SEKOLAH DASAR

The purpose of this study is to improve the learning outcomes of science of human body and animal 5th grade animal organ function through the application of interactive model based on flash. This form of research is a classroom action research of 2 cycles. Each cycle consists of 4 stages: planning, action implementation, observation and reflection. The subjects of the study were the 5th graders of SDN 05 Dagen as many as 20 students. Data collection techniques use observation, interview, test and documentation. Data analysis technique used is interactive analysis model which has three component that is data reduction, data presentation and conclusion drawing. Based on the results of research that is with the implementation of learning in the cycle I and cycle II can be concluded that there is an increase in learning outcomes by applying interactive multimedia based flash. This can be demonstrated by the increased ability of students from before and after action.