scholarly journals The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid

2007 ◽  
Vol 97 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Ardiansyah ◽  
Hitoshi Shirakawa ◽  
Takuya Koseki ◽  
Katsumi Hashizume ◽  
Michio Komai
Keyword(s):  
Lipid Metabolism ◽  
Ferulic Acid ◽  
Rice Bran ◽  
Spontaneously Hypertensive Rats ◽  
Control Diet ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome ◽  
Hepatic Triacylglycerol

The aim of this study is to investigate the effects of dietary supplementation with the Driselase-treated fraction (DF) of rice bran and ferulic acid (FA) on hypertension and glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHRSP at 4 weeks of age were divided into three groups, and for 8 weeks were fed (1) a control diet based on AIN-93M, (2) a DF of rice bran-supplemented diet at 60 g/kg and (3) an FA-supplemented diet at 0·01 g/kg. Means and standard errors were calculated and the data were tested by one-way ANOVA followed by a least significance difference test. The results showed that both the DF and FA diets significantly improved hypertension as well as glucose tolerance, plasma nitric oxide (NOx), urinary 8-hydroxy-2′-deoxyguanosine and other parameters. In particular, compared to the FA diet, the DF diet produced a significant improvement in urinary NOx, hepatic triacylglycerol and several mRNA expressions of metabolic parameters involved in glucose and lipid metabolisms. The results of the metabolic syndrome-related parameters obtained from this study suggest that the DF diet is more effective than the FA diet.

scholarly journals Dissecting the Role of Folr1 and Folh1 Genes in the Pathogenesis of Metabolic Syndrome in Spontaneously Hypertensive Rats

2018 ◽  
pp. 657-662 ◽  
Author(s):  
J. ŠILHAVÝ ◽  
J. KRIJT ◽  
J. SOKOLOVÁ ◽  
V. ZÍDEK ◽  
P. MLEJNEK ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Amino Acid ◽  
Spontaneously Hypertensive Rats ◽  
Brown Norway ◽  
Sulfur Amino Acid ◽  
Hypertensive Rats ◽  
Metabolic Disturbances ◽  
Spontaneously Hypertensive ◽  
Glucose And Lipid Metabolism ◽  
Amino Acid Levels

Increased levels of plasma cysteine predispose to obesity and metabolic disturbances. Our recent genetic analyses in spontaneously hypertensive rats (SHR) revealed mutated Folr1 (folate receptor 1) on chromosome 1 as a quantitative trait gene associated with reduced folate levels, hypercysteinemia and metabolic disturbances. The Folr1 gene is closely linked to the Folh1 (folate hydrolase 1) gene which codes for an enzyme involved in the hydrolysis of dietary polyglutamyl folates in the intestine. In the current study, we obtained evidence that Folh1 mRNA of the BN (Brown Norway) origin is weakly but significantly expressed in the small intestine. Next we analyzed the effects of the Folh1 alleles on folate and sulfur amino acid levels and consecutively on glucose and lipid metabolism using SHR-1 congenic sublines harboring either Folr1 BN and Folh1 SHR alleles or Folr1 SHR and Folh1 BN alleles. Both congenic sublines when compared to SHR controls, exhibited significantly reduced folate clearance and lower plasma cysteine and homocysteine levels which was associated with significantly decreased serum glucose and insulin concentrations and reduced adiposity. These results strongly suggest that, in addition to Folr1, the Folh1 gene also plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.

New insights on association between circadian rhythm and lipid metabolism in spontaneously hypertensive rats

Life Sciences ◽  
2021 ◽  
Vol 271 ◽  
pp. 119145
Author(s):  
Qingqing Hou ◽  
Shiming Zhang ◽  
Yuan Li ◽  
Huanjun Wang ◽  
Dan Zhang ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Lipid Metabolism ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Abstract P038: Testosterone Supplements Have Differential Effects on Blood Pressure in Old and Young Male Spontaneously Hypertensive Rats

Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Rodrigo O Maranon ◽  
Licy L Yanes Cardozo ◽  
Carolina Dalmasso ◽  
Chetan N Patil ◽  
Andrew Harris ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Young Male ◽  
Zucker Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Young Males ◽  
The Metabolic Syndrome ◽  
Younger Men ◽  
Obese Zucker Rats

Testosterone (“T”) supplements are widely used by men to improve their quality of life, libido, and protect against osteoporosis. In clinical studies, both high and low “T” levels were found to be associated with hypertension and cardiovascular risk. Endogenous “T” levels are reduced in obese men and rats. We have shown previously that “T” supplements in middle-aged (6 mos) obese Zucker rats improved symptoms of the metabolic syndrome and caused weight loss, but increased their blood pressure. How “T” supplements affect hypertensive men and rats is unknown. We hypothesized that “T” supplements would further increase blood pressure (BP) in both old and young male spontaneously hypertensive rats (SHR). Old (O=20-22 mos) and young (Y=10 wks) male SHR were treated with “T” (testosterone propionate 8 mg/10 mm silastic pellet; OT and YT, implanted sc) or placebo (empty pellets; OP and YP, sc). Pellets were changed every 3 weeks for 8 weeks. Mean arterial pressure (MAP) was measured by telemetry for 2 weeks. MAP in OP was higher than in YP (OP: 166±7 vs YP: 148±0.5 mmHg, p<0.001). As we predicted, “T” increased MAP in YT (YP: 148±1 vs YT: 157±1 mmHg, p<0.001). In contrast, “T” decreased MAP in OT (OP: 166±1 vs OT: 155±1 mmHg, p<0.001). These data suggest that in younger men, especially men who are already hypertensive, blood pressure should be monitored closely during “T” supplementation in order to prevent further cardiovascular disease. Since “T” reduced MAP in older male SHR, these data suggest that “T” supplements may not be as detrimental in older hypertensive men as in young men. Future studies will need to be done to determine the mechanisms by which “T” increases BP in young males and the mechanisms by which “T” reduces BP in old males. Supported by NIH-R01HL66072, PO1HL51971 (JFR), 14POST18640015 (ROM), EFF Endocrine Res Grant (LLY).

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