scholarly journals Pre-operative nutritional status does not alter the metabolic response to major gastrointestinal surgery in patients with oesophageal cancer

2007 ◽  
Vol 98 (1) ◽  
pp. 181-186 ◽  
Author(s):  
Peter H. Bisschop ◽  
Samuel Klein ◽  
Mariëtte T. Ackermans ◽  
Bruce W. Patterson ◽  
Erik Endert ◽  
...  
Keyword(s):  
Weight Loss ◽  
Nutritional Status ◽  
Oesophageal Cancer ◽  
Metabolic Response ◽  
Gastrointestinal Surgery ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Major Weight Loss ◽  
Catabolic Response ◽  
Substrate Kinetics

Malnutrition is associated with an increased incidence of perioperative morbidity and mortality. To evaluate the effect of malnutrition on the metabolic and inflammatory response to surgery in patients with oesophageal cancer, we studied the effects of oesophagectomy in six patients with major (13·9 (se 1·3) %) weight loss and five patients with minor (0·7 (se 0·6) %) weight loss in the 6 months before to surgery. Rates of appearance (Ra) of glucose, glycerol, leucine and urea were determined by stable isotopically labelled tracer infusion before and after surgery. C-reactive protein was measured as an inflammation marker. BMI was lower in the patients with major weight loss than those with minor weight loss (20·3 (se 0·7) and 24·9 (se 1·5) kg/m2, P = 0·02). With the exception of greater glucose Ra in the major weight loss than minor weight loss subjects (11·1 (se 0·3) v. 9·5 (se 0·3) μmol/kg per min, P = 0·01), there were no differences in substrate kinetics before surgery between groups. Surgery increased glucose Ra, leucine Ra and urea Ra by 41, 24 and 58 %, respectively, in the total group. Changes in substrate kinetics in response to surgery were not different between patients with major and minor weight loss. Surgery increased C-reactive protein concentrations to a comparable extent in both groups. In conclusion, major upper gastrointestinal tract surgery in patients with oesophageal cancer elicits a catabolic response, characterized by increased inflammation, glucose production and protein breakdown. However, this catabolic response does not seem to be influenced by pre-operative nutritional status.

scholarly journals Associations between Pre-Bariatric High-Sensitivity C-Reactive Protein and Post-Surgery Outcomes

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 721
Author(s):  
Tannaz Jamialahmadi ◽  
Mohsen Nematy ◽  
Simona Bo ◽  
Valentina Ponzo ◽  
Ali Jangjoo ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Success Rate ◽  
Liver Stiffness ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Post Surgery ◽  
Hs Crp

Background: Obesity is a chronic inflammatory condition associated with increased circulating levels of C-reactive protein (CRP). Bariatric surgery has been reported to be effective in improving both inflammatory and liver status. Our aims were to elucidate the relationships between pre-surgery high sensitivity-CRP (hs-CRP) values and post-surgery weight loss and liver steatosis and fibrosis in patients with severe obesity undergoing Roux-en-Y gastric bypass. Methods: We conducted an observational prospective study on 90 individuals with morbid obesity, who underwent gastric bypass. Anthropometric indices, laboratory assessment (lipid panel, glycemic status, liver enzymes, and hs-CRP), liver stiffness and steatosis were evaluated at baseline and 6-months after surgery. Results: There was a significant post-surgery reduction in all the anthropometric variables, with an average weight loss of 33.93 ± 11.79 kg; the mean percentage of total weight loss (TWL) was 27.96 ± 6.43%. Liver elasticity was significantly reduced (from 6.1 ± 1.25 to 5.42 ± 1.52 kPa; p = 0.002), as well as liver aminotransferases, nonalcoholic fatty liver disease fibrosis score (NFS) and the grade of steatosis. Serum hs-CRP levels significantly reduced (from 9.26 ± 8.45 to 3.29 ± 4.41 mg/L; p < 0.001). The correlations between hs-CRP levels and liver fibrosis (elastography), steatosis (ultrasonography), fibrosis-4 index, NFS, and surgery success rate were not significant. Regression analyses showed that serum hs-CRP levels were not predictive of liver status and success rate after surgery in both unadjusted and adjusted models. Conclusions: In patients with morbid obesity, bariatric surgery caused a significant decrease in hs-CRP levels, liver stiffness and steatosis. Baseline hs-CRP values did not predict the weight-loss success rate and post-surgery liver status.

L-carnitine infusions may suppress serum C-reactive protein and improve nutritional status in maintenance hemodialysis patients

2005 ◽  
Vol 15 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Vincenzo Savica ◽  
Domenico Santoro ◽  
Giampiero Mazzaglia ◽  
Franco Ciolino ◽  
Paolo Monardo ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Maintenance Hemodialysis Patients

scholarly journals Modified model for predicting early C-reactive protein levels after gastrointestinal surgery: A prospective cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0239709
Author(s):  
Yui Kawasaki ◽  
Soonhee Park ◽  
Kazunori Miyamoto ◽  
Ryusuke Ueki ◽  
Nobutaka Kariya ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Gastrointestinal Surgery ◽  
C Reactive Protein ◽  
Modified Model ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Statin treatment, phenotypic frailty and mortality among community-dwelling octogenarian men: the HBS cohort

2019 ◽  
Vol 49 (2) ◽  
pp. 258-263
Author(s):  
Kari Luotola ◽  
Satu Jyväkorpi ◽  
Annele Urtamo ◽  
Kaisu H Pitkälä ◽  
Mika Kivimäki ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Statin Treatment ◽  
Community Dwelling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Laboratory Examinations ◽  
The 1960S ◽  
Home Living ◽  
Glucose Status

Abstract Background statin treatment has increased also among people aged 80 years and over, but adverse effects potentially promoting frailty and loss of resilience are frequent concerns. Methods in the Helsinki Businessmen Study, men born in 1919–34 (original n = 3,490) have been followed up since the 1960s. In 2011, a random subcohort of home-living survivors (n = 525) was assessed using questionnaires and clinical (including identification of phenotypic frailty) and laboratory examinations. A 7-year mortality follow-up ensued. Results we compared 259 current statin users (median age 82 years, interquartile range 80–85 years) with 266 non-users (83; 80–86 years). Statin users had significantly more multimorbidity than non-users (prevalencies 72.1% and 50.4%, respectively, P &lt; 0.0001) and worse glucose status than non-users (prevalencies of diabetes 19.0% and 9.4%, respectively, P = 0.0008). However, there was no difference in phenotypic frailty (10.7% versus 11.2%, P = 0.27), and statin users had higher plasma prealbumin level than non-users (mean levels 257.9 and 246.3 mg/L, respectively, P = 0.034 adjusted for age, body mass index and C-reactive protein) implying better nutritional status. Despite morbidity difference, age-adjusted 7-year mortality was not different between the two groups (98 and 103 men among users and non-users of statins, respectively, hazard ratio 0.96, 95% confidence interval 0.72–1.30). Conclusions our study suggests that male octogenarian statin users preserved resilience and survival despite multimorbidity, and this may be associated with better nutritional status among statin users.

2P-0410 Effects of weight loss on oxidative stress, C-reactive protein and visceral fat

2003 ◽  
Vol 4 (2) ◽  
pp. 129
Author(s):  
J.Y. Kim ◽  
Y.J. Hyun ◽  
J.H. Lee ◽  
Y. Jang ◽  
H. Frier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Weight Loss ◽  
Visceral Fat ◽  
C Reactive Protein ◽  
Reactive Protein
Sign in / Sign up

Export Citation Format

Share Document