scholarly journals Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case–control study in China

2018 ◽  
Vol 119 (8) ◽  
pp. 957-964 ◽  
Author(s):  
Nai-Qi Zhang ◽  
Suzanne C. Ho ◽  
Xiong-Fei Mo ◽  
Fang-Yu Lin ◽  
Wu-Qing Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Vegetable Consumption ◽  
Chinese Women ◽  
Case Control ◽  
Cruciferous Vegetables ◽  
Control Study

AbstractAlthough previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case–control study from June 2007 to March 2017. Consumption of cruciferous vegetables was assessed using a validated FFQ. Dietary GSL and ITC were computed by using two food composition databases linking GSL and ITC contents in cruciferous vegetables with responses to the FFQ. The OR and 95 % CI were assessed by unconditional logistic regression after adjusting for the potential confounders. Significant inverse associations were found between consumption of cruciferous vegetables, GSL and ITC and breast cancer risk. The adjusted OR comparing the highest with the lowest quartile were 0·51 (95 % CI 0·41, 0·63) for cruciferous vegetables, 0·54 (95 % CI 0·44, 0·67) for GSL and 0·62 (95 % CI 0·50, 0·76) for ITC, respectively. These inverse associations were also observed in both premenopausal and postmenopausal women. Subgroup analysis by hormone receptor status found inverse associations between cruciferous vegetables, GSL and ITC and both hormone-receptor-positive or hormone-receptor-negative breast cancer. This study indicated that consumption of cruciferous vegetables, GSL and ITC was inversely associated with breast cancer risk among Chinese women.

scholarly journals A higher Dietary Inflammatory Index score is associated with a higher risk of breast cancer among Chinese women: a case–control study

2017 ◽  
Vol 117 (10) ◽  
pp. 1358-1367 ◽  
Author(s):  
Wu-Qing Huang ◽  
Xiong-Fei Mo ◽  
Yan-Bin Ye ◽  
Nitin Shivappa ◽  
Fang-Yu Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Control Study

AbstractPrevious studies have investigated the association between dietary inflammatory potential and the development of cancer. For breast cancer the results have been equivocal. The present study aimed to investigate whether higher Dietary Inflammatory IndexTM (DII) scores were associated with increased risk of breast cancer among Chinese women. A total of 867 cases and 824 controls were recruited into the present case–control study from September 2011 to February 2016. DII scores were computed based on baseline dietary intake assessed by a validated 81-item FFQ. The OR and 95 % CI were assessed by multivariable logistic regression after adjusting for various potential confounders. DII scores in this study ranged from −5·87 (most anti-inflammatory score) to +5·71 (most proinflammatory score). A higher DII score was associated with a higher breast cancer risk (adjusted ORquartile 4 v. 1 2·28; 95 % CI 1·71, 3·03; adjusted ORcontinuous 1·40; 95 %CI 1·25, 1·39). In stratified analyses, positive associations also were observed except for underweight women or women with either oestrogen receptor+ or progesterone receptor+ status (but not both). Results from this study indicated that higher DII scores, corresponding to more proinflammatory diets, were positively associated with breast cancer risk among Chinese women.

scholarly journals Associations between Coffee Products and Breast Cancer Risk: a Case-Control study in Hong Kong Chinese Women

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Priscilla Ming Yi Lee ◽  
Wing Cheong Chan ◽  
Carol Chi-hei Kwok ◽  
Cherry Wu ◽  
Sze-hong Law ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hong Kong ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Hong Kong Chinese ◽  
Control Study

scholarly journals Alcohol Consumption and Breast Cancer Risk According to Hormone Receptor Status in Japanese Women: A Case-Control Study

2018 ◽  
Vol 244 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Yoko Takizawa ◽  
Masaaki Kawai ◽  
Yoichiro Kakugawa ◽  
Yoshikazu Nishino ◽  
Noriaki Ohuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alcohol Consumption ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Japanese Women ◽  
Hormone Receptor Status ◽  
Control Study

Iron intake with the risk of breast cancer among Chinese women: a case–control study

2021 ◽  
pp. 1-13
Author(s):  
Kai-Yan Liu ◽  
Xiao-Li Feng ◽  
Xiong-Fei Mo ◽  
Fang-Yu Lin ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Red Meat ◽  
Food Sources ◽  
White Meat ◽  
Control Study

Abstract Objective: The current study evaluated the associations between different forms and sources of Fe and breast cancer risk in Southern Chinese women. Design: Case–control study. We collected data on the consumption of Fe from different forms and food sources by using a validated FFQ. Multivariable logistic regression and restricted cubic spline (RCS) analysis was used to reveal potential associations between Fe intake and breast cancer risk. Setting: A case-control study of women at three major hospitals in Guangzhou, China. Participants: From June 2007 to March 2019, 1591 breast cancer cases and 1622 age-matched controls were recruited. Results: In quartile analyses, Fe from plants and Fe from white meat intake were inversely associated with breast cancer risk, with OR of 0·65 (95 % CI 0·47, 0·89, Ptrend = 0·006) and 0·76 (95 % CI 0·61, 0·96, Ptrend = 0·014), respectively, comparing the highest with the lowest quartile. No associations were observed between total dietary Fe, heme or non-heme Fe, Fe from meat or red meat and breast cancer risk. RCS analysis demonstrated J-shaped associations between total dietary Fe, non-heme Fe and breast cancer, and reverse L-shaped associations between heme Fe, Fe from meat and Fe from red meat and breast cancer. Conclusion: Fe from plants and white meat were inversely associated with breast cancer risk. Significant non-linear J-shaped associations were found between total dietary Fe, non-heme Fe and breast cancer risk, and reverse L-shaped associations were found between heme Fe, Fe from meat or red meat and breast cancer risk.

Dietary Habits and Breast Cancer Risk: A Hospital-Based Case–Control Study in Chinese Women

2020 ◽  
Vol 20 (5) ◽  
pp. e540-e550 ◽  
Author(s):  
Jing Shi ◽  
Xinye Shao ◽  
Xiaoyu Guo ◽  
Wanxia Fang ◽  
Xin Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Dietary Habits ◽  
Chinese Women ◽  
Case Control ◽  
Control Study

Intake of total cruciferous vegetable and its contents of glucosinolates and isothiocyanates, glutathione S-transferases polymorphisms and breast cancer risk: a case–control study in China

2020 ◽  
Vol 124 (6) ◽  
pp. 548-557
Author(s):  
Nai-Qi Zhang ◽  
Xiong-Fei Mo ◽  
Fang-Yu Lin ◽  
Xiao-Xia Zhan ◽  
Xiao-Li Feng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Cruciferous Vegetables ◽  
Combined Effects ◽  
Cruciferous Vegetable ◽  
Glutathione S Transferases ◽  
Control Study

AbstractCruciferous vegetables contain high levels of glucosinolates (GSL) and isothiocyanates (ITC). ITC are known to induce glutathione S-transferases (GST) and thus exert their anticarcinogenic effects. This study explored the combined effects of cruciferous vegetable, GSL and ITC intake and GST polymorphisms on breast cancer risk. A total of 737 breast cancer cases and 756 controls were recruited into this case–control study. OR and 95 % CI were assessed by multivariable logistic regression. Higher cruciferous vegetable, GSL and ITC intakes were inversely associated with breast cancer risk, with adjusted OR of 0·48 (95 % CI 0·35, 0·65), 0·54 (95 % CI 0·40, 0·74) and 0·62 (95 % CI 0·45, 0·84), respectively. Compared with women carrying the GSTP1 rs1695 wild AA genotype and high cruciferous vegetable, GSL or ITC intake, carriers of the AA genotype with low cruciferous vegetable, GSL and ITC intake had greater risk of breast cancer, with adjusted OR of 1·43 (95 % CI 1·01, 1·87), 1·34 (95 % CI 1·02, 1·75) and 1·37 (95 % CI 1·05, 1·80), respectively. Persons with the GSTM1-null genotype and lower intake of cruciferous vegetables, GSL and ITC had higher risk of breast cancer than those with the GSTM1-present genotype and higher intake, with OR of 1·42 (95 % CI 1·04, 1·95), 1·43 (95 % CI 1·05, 1·96) and 1·45 (95 % CI 1·06, 1·98), respectively. Among women possessing the GSTT1-present genotype, low intake of cruciferous vegetables, GSL or ITC was associated with higher risk of breast cancer. But these interactions were non-significant. This study indicated that there were no significant interactions between cruciferous vegetable, GSL or ITC intake and GST polymorphisms on breast cancer risk.

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