scholarly journals Insulin-like growth factor I, binding proteins -1 and -3, risk of type 2 diabetes and macronutrient intakes in men

2019 ◽  
Vol 121 (8) ◽  
pp. 938-944
Author(s):  
Minna E. Similä ◽  
Jukka P. Kontto ◽  
Jarmo Virtamo ◽  
Katja A. Hätönen ◽  
Liisa M. Valsta ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Binding Proteins ◽  
Conditional Logistic Regression ◽  
Intervention Group ◽  
Diabetes Risk ◽  
Insulin Like Growth Factor ◽  
Baseline Serum ◽  
Igf I

AbstractThe insulin-like growth factor (IGF) axis may be involved in the development of type 2 diabetes. We examined the associations of IGF-I and IGF binding proteins (IGFBP)-1 and -3 with diabetes risk and evaluated macronutrient intakes related to the observed associations. In a nested case–control study of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish male smokers aged 50–69 years, the IGF variables were measured from baseline serum samples for a random sample of 310 men with diabetes diagnosed during a 12-year follow-up and for 310 controls matched by age, recruitment day and intervention group. Diet at baseline was assessed using a validated FFQ. The associations of IGF proteins with diabetes risk were estimated using conditional logistic regression and the associations with macronutrient intakes using linear regression. IGF-I and IGFBP-3 were not associated with the incidence of diabetes. Higher IGFBP-1 was associated with lower diabetes risk in an unadjusted crude model (OR 0·25; 95 % CI 0·15, 0·42 in the highest quartile compared with the lowest), but not after adjustment for BMI (corresponding OR 0·76; 95 % CI 0·41, 1·40). Intakes of carbohydrates, plant protein and milk protein associated positively and intake of meat protein and fat negatively with IGFBP-1 (P<0·005). IGFBP-1 was inversely associated with diabetes risk, but the association was substantially dependent on BMI. The associations between macronutrient intakes and IGFBP-1 may reflect influences of nutrients or foods on insulin concentrations.

scholarly journals The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes

2009 ◽  
Vol 25 (1) ◽  
pp. 3-12 ◽  
Author(s):  
Swapnil N. Rajpathak ◽  
Marc J. Gunter ◽  
Judith Wylie-Rosett ◽  
Gloria Y. F. Ho ◽  
Robert C. Kaplan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Glucose Homeostasis ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Birth weight modifies the relation between adulthood levels of insulin-like growth factor-1 and type 2 diabetes: a prospective cohort study

2021 ◽  
Vol 9 (1) ◽  
pp. e001885
Author(s):  
Tingting Geng ◽  
Mengying Wang ◽  
Xiang Li ◽  
Tao Zhou ◽  
Hao Ma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Birth Weight ◽  
Growth Factor ◽  
Early Life ◽  
Genetic Risk Score ◽  
Dependent Manner ◽  
Insulin Like Growth Factor ◽  
Baseline Serum ◽  
The Uk

IntroductionInsulin-like growth factor-1 (IGF-1) has been implicated in fetal and early-life growth and development of type 2 diabetes (T2D). We aimed to examine the interaction between circulating IGF-1 and birth weight in relation to risk of T2D.Research design and methodsWe included 181 090 adults, aged 39–70 years in the UK Biobank Study, who were free of diabetes or major cardiovascular diseases at baseline. Serum IGF-1 levels were determined using chemiluminescent immunoassay method. Birth weight was self-reported; a Genetic Risk Score (GRS) was calculated to define the genetically determined birth weight. The outcome was the incidence of T2D.ResultsWe identified 3299 incident T2D cases over an average of 9.9 years of follow-up. Among the participants with birth weight of ≥2.5 kg, IGF-1 levels were inversely associated with T2D risk in a dose-dependent manner (p-trend<0.001). In contrast, the association was not significant among those with birth weight of <2.5 kg (p-interaction=0.001). The GRS of birth weight did not interact with IGF-1 levels on T2D risk.ConclusionsOur results indicate that birth weight significantly modifies the relation between adulthood levels of circulating IGF-1 and the risk of T2D. Our findings highlight the importance of early-life risk factors in the development of the lifecourse prevention strategies targeting IGF-1 and T2D.

1559-P: Differential Effects of Type 1 (T1D) and Type 2 Diabetes (T2D) on the Growth Hormone (GH)-Insulin-Like Growth Factor (IGF) Axis in Youth

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1559-P
Author(s):  
JANET K. SNELL-BERGEON ◽  
JANE E.B. REUSCH ◽  
AMY D. BAUMGARTNER ◽  
MELANIE CREE-GREEN ◽  
KRISTEN J. NADEAU
Keyword(s):  
Type 2 Diabetes ◽  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Differential Effects

The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease

2008 ◽  
Vol 10 (3) ◽  
pp. 198-211 ◽  
Author(s):  
Vivienne A. Ezzat ◽  
Edward R. Duncan ◽  
Stephen B. Wheatcroft ◽  
Mark T. Kearney
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Binding Proteins ◽  
Igf I

Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I), IGF-II and des(1–3)IGF-I in rats

1991 ◽  
Vol 128 (2) ◽  
pp. 197-204 ◽  
Author(s):  
F. J. Ballard ◽  
S. E. Knowles ◽  
P. E. Walton ◽  
K. Edson ◽  
P. C. Owens ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Proteins ◽  
Rank Order ◽  
Insulin Like Growth Factor ◽  
Plasma Binding ◽  
Factor I ◽  
Igf I ◽  
The Mean ◽  
Growth Factor I ◽  
Sites Of Action

ABSTRACT Incubation of 125I-labelled insulin-like growth factor-I (IGF-I) with rat plasma at 4 °C led to the transfer of approximately half the radioactivity to 150 kDa and smaller complexes with IGF-binding proteins. The extent of association was greater with labelled IGF-II and essentially absent with the truncated IGF-I analogue, des(1–3)IGF-I. A greater degree of binding of IGF peptides with binding proteins occurred after i.v. injection of the tracers into rats, but most of the des(1–3)IGF-I radioactivity remained free. Measurement of the total plasma clearances showed the rapid removal of des(1–3)IGF-I compared with IGF-I and IGF-II; the mean clearances were 4·59, 1·20 and 1·34 ml/min per kg respectively. The mean steadystate volume of distribution was larger for des(1–3)IGF-I than for IGF-I and IGF-II (461, 167 and 181 ml/kg respectively), probably because of the differences in plasma protein binding. With all tracers, radioactivity appeared in the kidneys to a greater extent than in other organs. The amount of radioactivity found in the adrenals, brain, skin, stomach, duodenum, ileum plus jejunum and colon was in rank order, des(1–3)IGF-I > IGF-I > IGF-II. Since this ranking is the opposite of the abilities of the three IGF peptides to form complexes with plasma binding proteins, we propose that the plasma binding proteins inhibit the transfer of the growth factors to their tissue sites of action. Moreover, we suggest that IGF analogues that are cleared rapidly from blood may have greater biological potencies in vivo. Journal of Endocrinology (1991) 128, 197–204

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