Elevation of bovine serum C-reactive protein and serum amyloid P component levels by lactation

1991 ◽  
Vol 58 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Masami Morimatsu ◽  
Atsushi Watanabe ◽  
Kumiko Yoshimatsu ◽  
Toru Fujinaga ◽  
Masahiko Okubo ◽  
...  
Keyword(s):  
Bovine Serum ◽  
Serum Amyloid ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Lactating Cows ◽  
Serum Amyloid P Component ◽  
Amyloid P

SummaryC-reactive protein (CRP) and serum amyloid P component (SAP), which are known to increase in sera from humans and many other animals with acute inflammation caused by infection, toxic drug administration or injury, were previously purified from bovine serum. These serum levels were determined by enzyme-linked immunosorbent assay (ELISA) using specific antiserum to bovine CRP or SAP which was prepared by immunizing rabbits and goats with each purified protein. Among 68 healthy Holstein cows, 45 non-lactating cows had levels of CRP and SAP of 20·6±1·4 and 27·6 ± 1·3 μg/ml respectively; 23 lactating cows had higher levels of CRP and SAP (76·0±13·6 and 38·3±5·5 μg/ml respectively). In the latter group, there was a high correlation between milk yield and serum CRP levels (P <0·001). From these observations, it was assumed that lactation might stimulate CRP synthesis rather than SAP synthesis in bovine liver as an acute phase reaction, and that CRP might be called a lactation-associated protein.

scholarly journals Isolation and characterization of C-reactive protein and serum amyloid P component from bovine serum.

1989 ◽  
Vol 51 (4) ◽  
pp. 723-732 ◽  
Author(s):  
Masami MORIMATSU ◽  
Hirofumi SAKAI ◽  
Kumiko YOSHIMATSU ◽  
Osamu MINOWA ◽  
Shizuo YAMAMOTO ◽  
...  
Keyword(s):  
Bovine Serum ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Isolation And Characterization ◽  
Serum Amyloid P Component ◽  
Amyloid P

scholarly journals Vitamin D Correction Down-Regulates Serum Amyloid P Component Levels in Vitamin D Deficient Arab Adults: A Single-Arm Trial

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2880
Author(s):  
Osama Amer ◽  
Malak Khattak ◽  
Abdullah Alnaami ◽  
Naji Aljohani ◽  
Nasser Al-Daghri
Keyword(s):  
Vitamin D ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Post Intervention ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Study Participants ◽  
Amyloid P

Vitamin D (VD) has been observed to have anti-inflammatory properties. However, the effects of VD supplementation on the serum amyloid P component (SAP) has not been established. This study aimed to investigate the effect of VD supplementation on serum SAP levels in Arab adults. A total of 155 VD-deficient adult Saudis (56 males and 99 females) were recruited in this non-randomized, 6-month, single-arm trial. The intervention was as follows; cholecalciferol 50,000 international units (IU) every week for the first 2 months, followed by 50,000 twice a month for the next two months, and for the last two months, 1000 IU daily. Serum 25(OH)D, SAP, C-reactive protein (CRP), lipid profile, and glucose were assessed at baseline and post-intervention. At post-intervention, VD levels were significantly increased, while SAP levels significantly decreased in all study participants. Remarkably, this reduction in SAP was more significant in males than females after stratification. SAP was inversely correlated with VD overall (r = −0.17, p < 0.05), and only in males (r = −0.27, p < 0.05) after stratification according to sex after 6 months of VD supplementation. Such a relationship was not observed at baseline. VD supplementation can favorably modulate serum SAP concentrations in Arab adults, particularly in males.

Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component

Amyloid ◽  
2017 ◽  
Vol 24 (sup1) ◽  
pp. 28-29 ◽  
Author(s):  
Daisaku Ozawa ◽  
Ryo Nomura ◽  
P. Patrizia Mangione ◽  
Kazuhiro Hasegawa ◽  
Tadakazu Okoshi ◽  
...  
Keyword(s):  
Serum Amyloid ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P
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