The effect of cyclosporin A on the course ofParagonimus miyazakiiinfection in rats

1988 ◽  
Vol 62 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Yoshihisa Hashiguchi ◽  
Yoshisuke Okamura
Keyword(s):  
Cyclosporin A ◽  
Post Infection ◽  
Recovery Rate ◽  
Cyst Formation ◽  
Fungal Metabolite ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite ◽  
Time Of Administration ◽  
Lower Recovery

ABSTRACTThe effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course ofParagonimus miyazakiiinfection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA − 1 to + 3 days post-infection enhanced the growth and maturation ofP. miyazakii, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. This study shows that administration of CyA to rats affects the host-parasite relationship, depending on the time of administration of the drug.

scholarly journals Ancylostoma ceylanicum in the hamster: observations on the host—parasite relationship during primary infection

Parasitology ◽  
1989 ◽  
Vol 98 (2) ◽  
pp. 283-289 ◽  
Author(s):  
P. Garside ◽  
J. M. Behnke
Keyword(s):  
Post Infection ◽  
Primary Infection ◽  
Normal Values ◽  
Adult Stage ◽  
Hookworm Infection ◽  
Ancylostoma Ceylanicum ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Canine Models ◽  
Host Parasite

SUMMARYThe course of primary infection with a hamster-adapted strain of Ancylostoma ceylanicum was studied in inbred DSN and randomly bred WO/GD and WO/CR hamsters. Infective larvae were administered orally and began to develop in the small intestine without embarking on a tissue migration. Only the occasional larva was detected in other organ sites. It was concluded that the developing larvae moulted on days 3–4 and again to the pre-adult stage about 9–11 days post-infection. Worm burdens in infected hamsters were stable for at least 11 weeks after infection. There was no sudden expulsive phase and some adult worms survived for over 200 days. Overall the sex ratio of worms in groups of hamsters killed concurrently was about 50% although occasionally the ratio was biased in favour of one sex in individual animals. The blood packed cell volume (PCV) was significantly depressed 2 weeks following infection and continued to decline until a point of stability was achieved 4–5 weeks post-infection. The PCV subsequently remained depressed throughout the period of observation. Infected hamsters lost weight if kept in groups, but not when housed in separate cages. Groups of animals which lost weight did not recover to normal values within 11 weeks of infection. It is suggested that this model of hookworm infection has scope for exploring aspects of the host-parasite relationship which the canine models cannot fulfill adequately.

Cyclosporin A: antiparasite drug, modulator of the host-parasite relationship and immunosuppressant

Parasitology ◽  
1992 ◽  
Vol 105 (S1) ◽  
pp. S25-S40 ◽  
Author(s):  
L. H. Chappell ◽  
J. M. Wastling
Keyword(s):  
Cyclosporin A ◽  
Drug Administration ◽  
Gastrointestinal Nematodes ◽  
Laboratory Animals ◽  
Parasitic Infections ◽  
Filarial Nematodes ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite

SUMMARYCyclosporin A (CsA), a cyclic undecapeptide with powerful properties of immunosuppression, acts on parasitic infections in laboratory animals in various ways. The outcome of drug administrationin vivovaries with timing of treatment relative to infection, route of administration, dose and number of treatments applied. CsA is clearly antiparasitic against malaria, schistosomes, adult tapeworms, metacestodes and filarial nematodes. By contrast, it acts as an immunomodulator against trypanosomes andGiardia, by exacerbating infection; in the case ofLeishmaniaspp. the drug acts variously. In some other infections CsA acts both as an antiparasite drug and as an immunosuppressant (Toxoplasma, avian coccidiosis and gastrointestinal nematodes).

The host—parasite relationship ofSchistosoma haematobiumin CBA mice

Parasitology ◽  
1988 ◽  
Vol 97 (3) ◽  
pp. 403-424 ◽  
Author(s):  
A. M. Agnew ◽  
S. B. Lucas ◽  
M. J. Doenhoff
Keyword(s):  
Post Infection ◽  
Schistosoma Haematobium ◽  
Egg Laying ◽  
Male And Female ◽  
Cba Mice ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Hepatic Granulomas ◽  
The Mean ◽  
Host Parasite

SummaryThe host—parasite relationships of two geographical isolates ofSchistosoma haematobiumin CBA mice are described and compared to previous reports on this parasite in other experimental hosts and in man. The mean percentage establishment of worms in mice was 17% and was not affected by the age or sex of the host. Adult worm burdens remained constant over 20 weeks, but were reduced after 18 months of infection. Male and female worms reached mean maximum lengths of 4·78 and 5·9 mm respectively. Egg laying commenced 9·5 weeks after infection and eggs accumulated in the tissues throughout the period of infection. A large increase in the rate of egg accumulation occurred coincidental with the appearance of eggs in the bladder of some mice. Faecal eggs were first observed in some mice at 12·5 weeks and most mice excreted a few eggs by 17 weeks p.i. (post-infection). Eggs were not found in the urine of infected mice. Excreted eggs and eggs isolated from the livers of infected mice hatched, but the resulting miracidia were unable to infect appropriate snail hosts. The development of hepatic granulomas and egg-induced pathology in the bladder of mice is described.

Susceptibilities of Various Snail Intermediate Hosts of Schistosoma mansoni to Different Strains of the Parasite

1965 ◽  
Vol 39 (4) ◽  
pp. 363-376 ◽  
Author(s):  
M.F.A. Saoud
Keyword(s):  
Puerto Rico ◽  
Schistosoma Mansoni ◽  
Intermediate Hosts ◽  
Considerable Evidence ◽  
The Past ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Different Strains ◽  
Host Parasite ◽  
Comprehensive Studies

In the past two decades, considerable evidence has accumulated in the literature about the differences in the susceptibility of various intermediate hosts of Schistosoma mansoni to different strains of the parasite. Comprehensive studies on this aspect of host-parasite relationship have been published by Files & Cram (1949), Abdel-Malek (1950) and Files (1951). The results of more recent studies have been reported by Wright (1962) and Saoud (1964).In the present paper, the writer has studied the susceptibility of four intermediate hosts of S. mansoni from Brazil, Puerto Rico, Egypt and Tanganyika to some strains of the parasite.

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