Rhinocerebral mucormycosis with orbital and intracranial extension: a case report and review of optimum management

2006 ◽  
Vol 121 (2) ◽  
pp. 192-195 ◽  
Author(s):  
N Munir ◽  
N S Jones
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Surgical Debridement ◽  
Liposomal Amphotericin B ◽  
Intracranial Extension ◽  
Rhinocerebral Mucormycosis ◽  
Optimum Management

Rhinocerebral mucormycosis is a devastating, rapidly progressive and often fatal opportunistic fungal infection predominantly affecting individuals with underlying metabolic and/or immunological compromise. Intracranial extension of the disease has invariably been associated with mortality.We present a review of optimum management of rhinocerebral mucormycosis and a case report of sinonasal mucormycosis with intracranial and orbital extension which was treated successfully with a combination of systemic liposomal amphotericin B therapy and wide surgical debridement.

Successful treatment of rhinocerebral mucormycosis by a combination of aggressive surgical debridement and the use of systemic liposomal amphotericin B and local therapy with nebulized amphotericin – a case report

1998 ◽  
Vol 112 (4) ◽  
pp. 367-370 ◽  
Author(s):  
P. Raj ◽  
E. J. Vella ◽  
R.C. Bickerton
Keyword(s):  
Case Report ◽  
Amphotericin B ◽  
Successful Treatment ◽  
Acute Promyelocytic Leukaemia ◽  
Liposomal Amphotericin ◽  
Local Therapy ◽  
Surgical Debridement ◽  
Rhinocerebral Mucormycosis ◽  
Aggressive Management ◽  
High Index Of Suspicion

AbstractA case of mucormycosis involving the nose and paranasalsinuses in a 55-year-old man with recently diagnosed acute promyelocytic leukaemia is reported. It was successfully treated with a combination of aggressive surgical debridement and systemic amphotericin B. In addition, local nebulized amphotericin B was used as an adjunct totherapy. We believe this is only the second documented use of nebulized amphotericin in the management of sinonasal mucormycosis. The needfor a high index of suspicion and early aggressive management is emphasized.

scholarly journals Sporobolomyces salmonicolor: A case report of a rare cutaneous fungal infection

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984415
Author(s):  
Rahina Damji ◽  
Atreyi Mukherji ◽  
Farheen Mussani
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Multiple Organ ◽  
Liposomal Amphotericin B ◽  
Cutaneous Eruption ◽  
Organ Systems ◽  
Cutaneous Fungal Infection

We report a case of a 47-year-old male diagnosed with a cutaneous Sporobolomyces salmonicolor infection after suffering with an extensive cutaneous eruption for 4 years. Treatment can be difficult and options include voriconazole and liposomal amphotericin B. This infectious disease is extremely rare and can have extensive impact on multiple organ systems, including the skin.

Another Case Report of Rhinocerebral Mucormycosis Treated with Liposomal Amphotericin B and Surgery

1994 ◽  
Vol 18 (4) ◽  
pp. 653-654 ◽  
Author(s):  
K. K. T. Lim ◽  
M. J. Potts ◽  
D. W. Warnock ◽  
N. B. N. Ibrahim ◽  
E. M. Brown ◽  
...  
Keyword(s):  
Case Report ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Rhinocerebral Mucormycosis

scholarly journals Use of posaconazole in the treatment of infective rhinocerebral mucormycosis

2010 ◽  
Vol 124 (12) ◽  
pp. 1314-1317 ◽  
Author(s):  
K Kulendra ◽  
M Habibi ◽  
C Butler ◽  
P Clarke ◽  
D Howard
Keyword(s):  
Amphotericin B ◽  
Paranasal Sinuses ◽  
Liposomal Amphotericin ◽  
Disease Process ◽  
Type Ii Diabetes Mellitus ◽  
Surgical Debridement ◽  
Liposomal Amphotericin B ◽  
Test Results ◽  
Drug Induced ◽  
Rhinocerebral Mucormycosis

AbstractIntroduction:A patients with undiagnosed type II diabetes mellitus presented with infective rhinocerebral mucormycosis.Investigation results:Initial magnetic resonance imaging scans demonstrated an aggressive disease process involving the left orbit and paranasal sinuses. A repeated scan following treatment excluded intracranial spread or recurrence. Pus from the paranasal sinuses grew Rhizopus arrhizus on microbiological culture.Management:Initial treatment comprised intravenous liposomal amphotericin B, intravenous co-amoxiclav and surgical debridement. The patient's diabetes was managed medically. The development of drug-induced transaminitis required a change of medication. The dose of liposomal amphotericin B was reduced, and then titrated back up as the liver function test results improved. Posaconazole was also introduced and the patient was eventually discharged on this alone, as the maximum recommended cumulative dose of liposomal amphotericin B had been reached.Conclusions:Posaconazole may be used effectively in conjunction with surgical debridement in the treatment of patients with infective rhinocerebral mucormycosis who develop hepatotoxic side effects to liposomal amphotericin B. Posaconazole may also allow a reduction in the dose of liposomal amphotericin B, resulting in better tolerance.

scholarly journals Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report

2001 ◽  
Vol 1 (1) ◽  
Author(s):  
Atahan A Çagatay ◽  
Serkan S Öncü ◽  
Semra S Çalangu ◽  
Taner T Yildirmak ◽  
Halit H Özsüt ◽  
...  
Keyword(s):  
Case Report ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Rhinocerebral Mucormycosis ◽  
Incomplete Surgery

scholarly journals Disseminated fusariosis in a pediatric patient with acute lymphoblastic leukemia and prolonged fever - a case report

2018 ◽  
Vol 71 (9-10) ◽  
pp. 314-318
Author(s):  
Natasa Kacanski ◽  
Branislava Radisic ◽  
Jovanka Kolarovic
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Lymphoblastic Leukemia ◽  
Fusarium Species ◽  
Water System ◽  
Liposomal Amphotericin B ◽  
Fusarium Infection ◽  
Days Of Therapy

Introduction. Infections caused by fungi of Fusarium species occur in immunocompromised individuals as disseminated diseases. Case Report. This case report presents a 5-year-old boy with acute lymphoblastic leukemia who developed a disseminated fusarium infection during reinduction chemotherapy. Fever was the main symptom and it lasted for 15 weeks. Refractory fever despite broad-spectrum antibiotics, as well as nausea, myalgia, pulmonary symptoms with detection of pulmonary infiltrates, liver and spleen involvement indicated an invasive fungal infection. The patient received fluconazole, voriconazole, liposomal amphotericin B and caspofungin. Since high temperature was persistent, diagnostic laparoscopy of the abdomen was done. Scattered lesions, up to 2 mm in diameter, were observed macroscopically on the surface of the liver and spleen. The liver culture was positive for Acinetobacter and Fusarium species. After 38 days of therapy with liposomal amphotericin B and 3 days of ciprofloxacin, the patient became afebrile. Itraconazole (according to the antimycogram) was continued during maintenance therapy. Abdominal ultrasound was completely normal after 5 months of treatment with itraconazole. This boy was our first patient with a disseminated fusarium infection. At that time, Fusarium was detected in the hospital water system and in hospital air samples. Conclusion. A timely diagnosis of invasive fungal diseases in children is a big challenge. Over the past decade, there has been an increase in survival rate of patients with invasive fusariosis due to much more common use of voriconazole or combined antifungal therapy.

Mediastinal Mucormycosis: Case report, review of literature and treatment with continuous liposomal amphotericin B irrigation

Mycoses ◽  
2019 ◽  
Author(s):  
Joseph D. Cooper ◽  
Robert A. Gotoff ◽  
Michael A. Foltzer ◽  
Russell A. Carter ◽  
Thomas J. Walsh
Keyword(s):  
Case Report ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Review Of Literature

Rhinocerebral mucormycosis: Use of liposomal amphotericin B

1991 ◽  
Vol 105 (7) ◽  
pp. 575-577 ◽  
Author(s):  
Edward W. Fisher ◽  
Abbad Toma ◽  
Phillip H. Fisher ◽  
Anthony D. Cheesman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Supportive Therapy ◽  
Liposomal Amphotericin B ◽  
Rhinocerebral Mucormycosis ◽  
System A ◽  
The Central Nervous System ◽  
Liposomal Delivery

AbstractRhinocerebral mucormycosis is a rare but often fatal condition characterized by an aggressive necrotizing infection spreading from the nose to the paranasal sinuses, orbit and hence to the central nervous system. A case is reported in which a diabetic male with advanced mucormycosis was successfully treated by a combination of surgery, supportive therapy and liposomal amphotericin B. Liposomal delivery allows the drug to be both less toxic and more effective, and this is the first reported case of its use in rhinocerebral mucormycosis.

Haemopoietic Cell Transplantation of Patients with a History of Deep or Invasive Fungal Infection during Prophylaxis with Liposomal Amphotericin B

2005 ◽  
Vol 113 (2) ◽  
pp. 104-108 ◽  
Author(s):  
William H. Krüger ◽  
Bettina Rüssmann ◽  
Maike de Wit ◽  
Nicolaus Kröger ◽  
Helmut Renges ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Amphotericin B ◽  
Cell Transplantation ◽  
Invasive Fungal Infection ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
History Of
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