Neonatal stridor in association with herpes simplex infection of the larynx

1998 ◽  
Vol 112 (12) ◽  
pp. 1192-1193 ◽  
Author(s):  
H. R. Sharp ◽  
S. P. A. Blaney ◽  
G. A. J. Morrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex ◽  
Neonatal Period ◽  
Upper Aerodigestive Tract ◽  
Herpes Encephalitis ◽  
Simplex Infection ◽  
The Central Nervous System ◽  
Localized Disease ◽  
Simplex Virus

AbstractHerpes simplex virus (HSV) infection in the neonatal period may be confined to the eyes, skin and upper aerodigestive tract or may be widely disseminated to other organs, with particular recognition of involvement of the central nervous system (CNS) causing herpes encephalitis (Whitley et al., 1980a, b; Andersen, 1987).Primary laryngeal HSV infection is extremely uncommon. We present a case of acute neonatal stridor secondary to such localized disease and discuss its management.

scholarly journals Cerebrospinal fluid challenges for the diagnosis of herpes simplex infection in the central nervous system

2020 ◽  
Vol 78 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Samya Jezine DA SILVA ◽  
Mauro Jorge CABRAL-CASTRO ◽  
Maria Angélica GUIMARÃES ◽  
José Mauro PERALTA ◽  
Marzia PUCCIONI-SOHLER
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Herpes Simplex ◽  
Severe Disease ◽  
Serum Samples ◽  
Specific Antibodies ◽  
Simplex Infection ◽  
The Central Nervous System ◽  
Simplex Virus

Abstract Herpes simplex virus (HSV) is a cause of a severe disease of the central nervous system (CNS) in humans. The demonstration of specific antibodies in the cerebrospinal fluid (CSF) may contribute to the retrospective neurological diagnosis. However, the commercial immunological tests for HSV infection are for use in serum samples. Objective: The aim of the present study was to adapt a commercial kit anti-HSV IgG used for serum samples to be performed with a CSF sample. Methods: Forty CSF specimens from 38 patients with suspected CNS HSV infection were serially diluted for detecting anti-HSV IgG by enzyme immunoassay (EIA). The same samples were also analyzed with the polymerase chain reaction (PCR). Results: The sensitivity of EIA test for HSV was 5% (dilution 1:40) and 65% (dilution 1:2) in CSF, and HSV DNA PCR was 15%. The combined analysis of EIA (dilution 1:2) and PCR increased the sensitivity up to 72.5%. The inflammatory CSF was associated with positive HSV PCR. Conclusions: We demonstrated the importance to adapt serological anti-HSV IgG EIA test for CSF assays to increase the accuracy of the analysis, considering the low concentration of specific antibodies in CSF.

Herpes Simplex Virus as a Gene-Delivery Vector for the Central Nervous System

Viral Vectors ◽  
1995 ◽  
pp. 1-23 ◽  
Author(s):  
Joseph C. Glorioso ◽  
Mary Ann Bender ◽  
William F. Goins ◽  
Neal DeLuca ◽  
David J. Fink
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Delivery ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
The Central Nervous System ◽  
Simplex Virus
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